CD86 Protein (CD86) (Fc Tag)

Produktnummer ABIN2566448

Recombinant CD86-Protein exprimiert in HEK-293 Cells.

Kurzübersicht für CD86 Protein (CD86) (Fc Tag) (ABIN2566448)

Target: CD86

Protein-Typ: Recombinant

Spezies: Cynomolgus, Rhesusaffen

Quelle: HEK-293 Cells

Applikation: Western Blotting (WB)

Reinheit: 95 % as determined by SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses CD86 Protein ist gelabelt mit Fc Tag.

Produktmerkmale:

Fusion tag: C-Fc Tag

Anwendungsinformationen

Applikationshinweise: This recombinant protein can be used for WB. For research use only.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 50 mM tris, 100 mM glycine, pH 7.5

Lagerung: -80 °C,-20 °C

Informationen zur Lagerung: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.

Antigendetails

Target: CD86

Andere Bezeichnung: CD86

Hintergrund: Cluster of Differentiation 86 (CD86) is also known as B-lymphocyte activation antigen B7-2, is a type I membrane protein that is a member of the immunoglobulin superfamily, and is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B72 is expressed at low levels on monocytes and can be upregulated through interferon γ. CD86 is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells. Recent study has revealed that B7-2 promotes the generation of a mature APC repertoire and promotes APC function and survival. Furthermore, the B7 proteins are also involved in innate immune responses by activating NF-κB-signaling pathway in macrophages. CD86 thus is regarded as a promising candidate for immune therapy. CD86+ macrophages in Hodgkin lymphoma patients are an independent marker for potential nonresponse to firstline-therapy.

Molekulargewicht: 52 kDa

Gen-ID: 714390

UniProt: Q9BDM4

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation