Midkine Protein

Produktnummer ABIN2468825

Produktdetails

Target: Midkine (MDK) (Midkine (Neurite Growth-Promoting Factor 2) (MDK))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: Escherichia coli (E. coli)

Sequenz: MVAKKKEKVK KGSECSEWTW GPCTPSSKDC GMGFREGTCG AQTQRVHCKV PCNWKKEFGA DCKYKFESWG ACDGSTGTKA RQGTLKKARY NAQCQETIRV TKPCTSKTKS KTKAKKGKGK D

Produktmerkmale: Biological activity was determined by its ability to chemoattract human neutrophils using a concentration range of 10-100 ng/mL.

Reinheit: < 98 % by SDS-PAGE gel and HPLC analyses.

Endotoxin-Niveau: Endotoxin level is less than 0.1 ng per μg (1 EU/μg).

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Handhabung: As with any protein, exposing Midkine recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Lagerung: -20 °C

Informationen zur Lagerung: The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted Midkine stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.

Haltbarkeit: 24 months

Antigendetails

Target: Midkine (MDK) (Midkine (Neurite Growth-Promoting Factor 2) (MDK))

Andere Bezeichnung: Midkine (MDK Produkte)

Synonyme: ARAP Protein, MK Protein, NEGF2 Protein, Mek Protein, MK-B Protein, PTF-alpha-1 Protein, mdk Protein, midkine Protein, negf2 Protein, RIHB Protein, cb518 Protein, fb79b05 Protein, fj33b02 Protein, fj48a12 Protein, mdk2 Protein, plei2 Protein, wu:fb79b05 Protein, wu:fj33b02 Protein, wu:fj48a12 Protein, MK-A Protein, PTF-alpha-2 Protein, X-PTF-alpha1 Protein, XMK Protein, mdk-a Protein, mdk-b Protein, midkine Protein, midkine L homeolog Protein, midkine (neurite growth-promoting factor 2) Protein, midkine b Protein, midkine S homeolog Protein, MDK Protein, Mdk Protein, mdk.L Protein, mdkb Protein, mdk.S Protein

Hintergrund: Midkine and its functionally-related protein Pleiotrophin are heparin-binding neurotrophic factors that signal through the same receptor, known as anaplastic lymphoma kinase (ALK). MK plays an important regulatory role in epithelial-mesenchymal interactions during fetal development and in postnatal lung development. MK chemoattracts embryonic neurons, neutrophils and macrophages, and by signaling through the ALK receptor it exerts angiogenic, growth and survival activities during tumorgenesis. Recombinant murine Midkine is a 13.4 kDa protein containing 121 amino acid residues including five intra-molecular disulfide bonds.

Gen-ID: 17242

NCBI Accession: NP_001012335

OMIM: 59894790

UniProt: P12025

Pathways: RTK Signalweg, M Phase, Skeletal Muscle Fiber Development