Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

VEGF Protein (AA 27-191)

Dieses Recombinant VEGF-Protein wird in HEK-293 Cells exprimiert und wurde in 3+ Publikationen erwähnt.
Produktnummer ABIN2181903

Kurzübersicht für VEGF Protein (AA 27-191) (ABIN2181903)

Target

Alle VEGF Proteine anzeigen
VEGF (Vascular Endothelial Growth Factor (VEGF))

Protein-Typ

Recombinant

Biologische Aktivität

Active

Spezies

  • 11
  • 6
  • 1
  • 1
Human

Quelle

  • 6
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
HEK-293 Cells

Reinheit

>98 % as determined by SDS-PAGE.

Güteklasse

HPLC verified
  • Proteineigenschaft

    AA 27-191

    Marke

    ActiveMax®

    Sequenz

    AA 27-191

    Produktmerkmale

    This protein carries no "tag". The protein has a calculated MW of 19 kDa (monomer). As a result of glycosylation, the protein migrates as 24 kDa (monomer) under reducing (R) condition, and 43-50 kDa (homodimer) under non-reducing (NR) condition (SDS-PAGE).

    Sterilität

    0.22 μm filtered

    Endotoxin-Niveau

    Less than 1.0 EU per μg by the LAL method.
  • Möchten Sie weitere Optionen für dieses Protein ?

    !
    Entdecken Sie unsere vordefinierten maßgeschneiderten Proteine und Proteinservices!

    Ihr Projekt erfordert weitere Anpassungen? Kontaktieren Sie uns und entdecken Sie unsere maßgeschneiderten Proteinlösungen

  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Buffer

    PBS, pH 7.4

    Handhabung

    Please avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Stumpf, Wimmer, Lorenz, Stieger: "Creation of different bioluminescence resonance energy transfer based biosensors with high affinity to VEGF." in: PLoS ONE, Vol. 15, Issue 3, pp. e0230344, (2020) (PubMed).

    Chen, Hsueh, Lee, Tsai, Tsai, Chiang: "FGF primes angioblast formation by inducing ETV2 and LMO2 via FGFR1/BRAF/MEK/ERK." in: Cellular and molecular life sciences : CMLS, (2020) (PubMed).

    Keys, Wetter, Hang, Rutschmann, Russo, Mally, Steffen, Zuppiger, Müller, Schneider, Faridmoayer, Lin, Aebi: "A biosynthetic route for polysialylating proteins in Escherichia coli." in: Metabolic engineering, Vol. 44, pp. 293-301, (2018) (PubMed).

  • Target

    VEGF (Vascular Endothelial Growth Factor (VEGF))

    Andere Bezeichnung

    VEGF

    Hintergrund

    VEGF165 is the most abundant splice variant of VEGF-A. VEGF165 is produced by a number of cells including endothelial cells, macrophages and T cells. VEGF165 is involved in angiogenesis, vascular endothelial cell survival, growth, migration and vascular permeability. VEGF gene expression is induced by hypoxia, inflammatory cytokines and oncogenes. VEGF165 binds to heparan sulfate and is retained on the cell surface and in the extracellular matrix. VEGF165 binds to the receptor tyrosine kinases, VEGFR1 and VEGFR2. VEGF165 is the only splice variant that binds to co-receptors NRP-1 and NRP-2 that function to enhance VEGFR2 signaling. Binding of VEGF165 to VEGFR1 and VEGFR2 leads to activation of the PI3K/AKT, p38 MAPK, FAK and paxillin. VEGF plays a key role in tumor angiogenesis in many cancers.

    Molekulargewicht

    19.2 kDa

    NCBI Accession

    NP_001165097
Sie sind hier:
Chat with us!