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Vascular Endothelial Growth Factor (VEGF) (AA 27-191) (Active) protein (Biotin) Protein

VEGF Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active
Pubmed (1 reference)
Produktnummer ABIN2181906
$1,914.00
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target Alle VEGF Proteine anzeigen
    VEGF
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 27-191
    Spezies
    • 14
    • 9
    • 2
    Human
    Quelle
    • 8
    • 7
    • 3
    • 2
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses VEGF Protein ist gelabelt mit Biotin.
    Marke
    MABSol®,UltraLys
    Sequenz
    AA 27-191
    Spezifität
    The primary amines in the side chains of lysine residues and the N-terminus of the protein are conjugated with biotins using standard chemical labeling method. A standard biotin reagent (13.5 angstroms) is used in this product.
    Produktmerkmale
    The product does NOT contain any epitope tags. The protein has a calculated MW of 19 kDa (monomer). The protein migrates as 24 kDa (monomer) on a SDS-PAGE gel under reducing (R) condition due to glycosylation and 43-50 kDa under non-reducing (NR) condition.
    Reinheit
    >95 % as determined by reduced SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Kommentare

    A chemically labeled biotinylated protein with ultra sensitivity.
    The product is produced using a chemical labeling approach. The primary amines in the side chains of lysine residues and the N-terminus of protein are conjugated with biotins.
    Chemical labeling usually results in multiple biotin attachment on a single protein molecule, which could potentially lead to higher detection sensitivity.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • McGonigle, Majumder, Kolber-Simonds, Wu, Hart, Noland, TenDyke, Custar, Li, Du, Postema, Lai, Twine, Woodall-Jappe, Nomoto: "Neuropilin-1 drives tumor-specific uptake of chlorotoxin." in: Cell communication and signaling : CCS, Vol. 17, Issue 1, pp. 67, (2019) (PubMed).

  • Target
    VEGF
    Andere Bezeichnung
    VEGF (VEGF Produkte)
    Synonyme
    MVCD1, VEGF, VPF, Vegf, Vegf120, Vegf164, Vegf188, Vpf, VEGF-A, VEGF164, eVEGF120, eVEGF164, vegf-a, vegf, vascular endothelial growth factor A, vascular endothelial growth factor A L homeolog, vascular endothelial growth factor, vascular endothelial growth factor precursor, VEGFA, Vegfa, vegfa.L, VEGF, vegf
    Hintergrund
    VEGF165 is the most abundant splice variant of VEGF-A. VEGF165 is produced by a number of cells including endothelial cells, macrophages and T cells. VEGF165 is involved in angiogenesis, vascular endothelial cell survival, growth, migration and vascular permeability. VEGF gene expression is induced by hypoxia, inflammatory cytokines and oncogenes. VEGF165 binds to heparan sulfate and is retained on the cell surface and in the extracellular matrix. VEGF165 binds to the receptor tyrosine kinases, VEGFR1 and VEGFR2. VEGF165 is the only splice variant that binds to co-receptors NRP-1 and NRP-2 that function to enhance VEGFR2 signaling. Binding of VEGF165 to VEGFR1 and VEGFR2 leads to activation of the PI3K/AKT, p38 MAPK, FAK and paxillin. VEGF plays a key role in tumor angiogenesis in many cancers.
    Molekulargewicht
    19.2 kDa
    NCBI Accession
    NP_001165097
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