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VEGF Protein (Vascular Endothelial Growth Factor) (AA 27-147) (His tag)

VEGF Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active
Produktnummer ABIN2870705
$404.62
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target Alle VEGF Proteine anzeigen
    VEGF (Vascular Endothelial Growth Factor (VEGF))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 27-147
    Spezies
    • 14
    • 9
    • 2
    Human
    Quelle
    • 8
    • 7
    • 3
    • 2
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses VEGF Protein ist gelabelt mit His tag.
    Sequenz
    AA 27-147
    Produktmerkmale
    This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 15 kDa. As a result of glycosylation, the protein migrates as 17 kDa and 20 kDa under reducing (R) condition, and 35-45 kDa under non-reducing (NR) condition (SDS-PAGE).
    Reinheit
    >95 % as determined by reduced SDS-PAGE.
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
  • Target
    VEGF (Vascular Endothelial Growth Factor (VEGF))
    Andere Bezeichnung
    VEGF (VEGF Produkte)
    Synonyme
    MVCD1, VEGF, VPF, Vegf, Vegf120, Vegf164, Vegf188, Vpf, VEGF-A, VEGF164, eVEGF120, eVEGF164, vegf-a, vegf, vascular endothelial growth factor A, vascular endothelial growth factor A L homeolog, vascular endothelial growth factor, vascular endothelial growth factor precursor, VEGFA, Vegfa, vegfa.L, VEGF, vegf
    Hintergrund
    Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, and is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. Alternatively spliced isoforms of 121,145,165,183,189 and 206 amino acids in length are expressed in humans. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 is the only form that lacks a basic heparinbinding region and is freely diffusible. Mouse embryos expressing only the corresponding isoform (VEGF120) do not survive to term, and show defects in skeletogenesis. Human VEGF121 shares 87 % aa sequence identity with corresponding regions of mouse and rat, 93 % with feline, equine and bovine, and 91 %, 95 % and 96 % with ovine, canine and porcine VEGF, respectively. VEGF121 induces the proliferation of lymphatic endothelial cells. The lymphangiogenesis may be promoted by upregulation of VEGF121, which may in turn act in part via induction of VEGF-C.
    Molekulargewicht
    14.9 kDa
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