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Interleukin 2 Receptor, alpha (IL2RA) (AA 22-213) (Active) protein (Fc Tag) Protein

IL2RA Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Produktnummer ABIN2181381
$314.60
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target Alle CD25 (IL2RA) Proteine anzeigen
    CD25 (IL2RA)
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 22-213
    Spezies
    • 17
    • 9
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Quelle
    • 11
    • 8
    • 5
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses CD25 Protein ist gelabelt mit Fc Tag.
    Sequenz
    AA 22-213
    Produktmerkmale
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 48.4 Kda. The protein migrates as 60-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >95 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    Tris with Glycine, Arginine and NaCl,  pH 7.5
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Target
    CD25 (IL2RA)
    Andere Bezeichnung
    IL-2 R alpha (IL2RA Produkte)
    Synonyme
    CD25, IDDM10, IL2R, TCGFR, IL2RAC, IL-2RA, Il2r, Ly-43, interleukin 2 receptor subunit alpha, interleukin-2 receptor subunit alpha-like, interleukin 2 receptor, alpha chain, IL2RA, Il2ra, LOC100222957
    Hintergrund
    Interleukin-2 receptor subunit alpha (IL2RA) is also known as IL-2R subunit alpha, IL-2-RA, IL2-RA, TAC antigen, p55, CD antigen CD25, is a type I transmembrane glycoprotein. IL2RA is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.
    Molekulargewicht
    48.4 kDa
    NCBI Accession
    NP_000408
    Pathways
    JAK-STAT Signalweg, Growth Factor Binding, Activated T Cell Proliferation
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