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Interleukin 12 alpha (IL12A) (AA 23-219) protein (Fc Tag) Protein

IL12A Spezies: Human Wirt: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
Produktnummer ABIN2181329
$275.00
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target Alle IL12A Proteine anzeigen
    IL12A
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 23-219
    Spezies
    • 9
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Quelle
    • 16
    • 12
    • 3
    • 2
    • 1
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses IL12A Protein ist gelabelt mit Fc Tag.
    Sequenz
    AA 23-219
    Produktmerkmale
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 49.2 kDa. The protein migrates as 65-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >90 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    Tris with Glycine, Arginine and NaCl,  pH 7.5
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Target
    IL12A
    Andere Bezeichnung
    IL-12A (IL12A Produkte)
    Synonyme
    CLMF, IL-12A, NFSK, NKSF1, P35, CLMF2, IL-12B, NKSF, NKSF2, p40, Il-12b, Il12p40, Il-12p40, Il12, IL-12p40, IL-12p35, Il-12a, Ll12a, p35, IL12p35, Il-12 p35, IL12p40, IL12, IL-12 p35, interleukin 12A, interleukin 12B, interleukin 12b, interleukin 12a, Interleukin 12 level, IL12A, IL12B, Il12b, Il12a, IL12, il12a
    Hintergrund
    Interleukin-12 (IL12) is also known as natural killer cell stimulatory factor (NKSF), cytotoxic lymphocyte maturation factor (CLMF) , is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). IL12 is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is involved in the differentiation of naive T cells into Th0 cells and plays an important role in the activities of natural killer cells and T lymphocytes.IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels. Interleukin-12 subunit alpha (IL12A) also known as NKSF1, CLMF1 and P35, IL12A shows significant sequence similarity to IL-6, G-CSF, and exerts biological activities only when the IL12B is co-expressed. IL12B deficient mice are resistant to the induction of experimental chronic inflammatory diseases whereas IL12A knock-out mice develop more severe forms, suggesting opposite functions of the two subunits in the outcome of chronic inflammatory diseases.
    Molekulargewicht
    49.2 kDa
    UniProt
    P29459
    Pathways
    JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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