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Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 31-932) (Active) protein (His tag) Protein

IGF1R Spezies: Human Wirt: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Produktnummer ABIN2181260
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  • Target Alle IGF1R Proteine anzeigen
    IGF1R
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 31-932
    Spezies
    • 20
    • 6
    • 4
    • 1
    • 1
    Human
    Quelle
    • 9
    • 8
    • 8
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses IGF1R Protein ist gelabelt mit His tag.
    Sequenz
    AA 31-932
    Produktmerkmale
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 104 kDa (single chain), 81 kDa (α subunit) and 23 kDa (β subunit). The protein migrates as 120 kDa, 81 kDa and 35 kDa under reducing (R) condition (SDS-PAGE).
    Reinheit
    >90 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
    Biological Activity Comment
    Biological Activity: Measured by its ability to bind human IGF-I in a functional ELISA.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Target
    IGF1R
    Andere Bezeichnung
    IGF-I R (IGF1R Produkte)
    Synonyme
    CMT2N, CD221, IGFIR, IGFR, JTK13, IGFIRC, IGFR1, IGF-1R, IGF1R, DKFZp469I0618, igf-1r, xIGF-1R, xIGFR, xigf1r, A330103N21Rik, D930020L01, hyft, igf-ir, IGF-IRa, sb:eu1090, wu:fi20b10, alanyl-tRNA synthetase, insulin like growth factor 1 receptor, insulin-like growth factor 1 receptor, insulin-like growth factor 1, insulin-like growth factor I receptor, insulin like growth factor 1 receptor S homeolog, insulin-like growth factor 1a receptor, AARS, IGF1R, Igf1r, igf1r, Igf1, LOC780503, LOC100136427, igf1r.S, igf1ra
    Hintergrund
    The Insulin-like Growth Factor 1 Receptor (IGF1) is also known as CD221, JTK13. and is a transmembrane receptor that is activated by IGF-1 and by the related growth factor IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF1R is make up of two alpha subunits and two beta subunits ,the Both the α and β subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds to form a functional transmembrane αβ chain.The α chains are located extracellularly while the β subunit spans the membrane and are responsible for intracellular signal transduction upon ligand stimulation. IGF1R have a binding site for ATP, which is used to provide the phosphates for autophosphorylation. There is a 60 % homology between IGF1R and the insulin receptor. In response to ligand binding, the α chains induce the tyrosine autophosphorylation of the β chains. This event triggers a cascade of intracellular signaling that, while somewhat cell type specific, often promotes cell survival and cell proliferation.
    Molekulargewicht
    81.0 kDa, 23.8 kDa
    NCBI Accession
    NP_000866
    UniProt
    P08069
    Pathways
    RTK Signalweg, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagie
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