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Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) (Active) protein (His tag) Protein

ErbB2/Her2 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Pubmed (15 Referenzen)
Produktnummer ABIN2181214
$385.00
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target Alle ErbB2/Her2 Proteine anzeigen
    ErbB2/Her2
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 23-652
    Spezies
    • 36
    • 6
    • 4
    • 2
    • 1
    Human
    Quelle
    • 21
    • 10
    • 9
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses ErbB2/Her2 Protein ist gelabelt mit His tag.
    Sequenz
    AA 23-652
    Produktmerkmale
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 70.2 kDa. The protein migrates as 110-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >95 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Hao, Yu, Bai, McBride, Huang: "Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex." in: PLoS ONE, Vol. 14, Issue 5, pp. e0216095, (2020) (PubMed).

    Shinozaki, Hashimoto, Fukui, Uchiyama: "Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities." in: Scientific reports, Vol. 7, Issue 1, pp. 5794, (2019) (PubMed).

    Wang, Forterre, Zhao, Frimannsson, Delcayre, Antes, Efron, Jeffrey, Pegram, Matin: "Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation." in: Molecular cancer therapeutics, Vol. 17, Issue 5, pp. 1133-1142, (2019) (PubMed).

    Hussack, Raphael, Lowden, Henry: "Isolation and characterization of camelid single-domain antibodies against HER2." in: BMC research notes, Vol. 11, Issue 1, pp. 866, (2019) (PubMed).

    Ollier, Wassmann, Monney, Ries Fecourt, Gn, C A, Ayoub, Stutz, Gudi, Blein: "Single-step Protein A and Protein G avidity purification methods to support bispecific antibody discovery and development." in: mAbs, Vol. 11, Issue 8, pp. 1464-1478, (2019) (PubMed).

    Rosenthal, Stone, Koski, Zimmerman: "LEAPS Vaccine Incorporating HER-2/neu Epitope Elicits Protection That Prevents and Limits Tumor Growth and Spread of Breast Cancer in a Mouse Model." in: Journal of immunology research, Vol. 2017, pp. 3613505, (2018) (PubMed).

    Zhou, Chitneni, Devoogdt, Zalutsky, Vaidyanathan: "Fluorine-18 labeling of an anti-HER2 VHH using a residualizing prosthetic group via a strain-promoted click reaction: Chemistry and preliminary evaluation." in: Bioorganic & medicinal chemistry, Vol. 26, Issue 8, pp. 1939-1949, (2018) (PubMed).

    Anami, Yamazaki, Xiong, Gui, Zhang, An, Tsuchikama: "Glutamic acid-valine-citrulline linkers ensure stability and efficacy of antibody-drug conjugates in mice." in: Nature communications, Vol. 9, Issue 1, pp. 2512, (2018) (PubMed).

    Lowden, Henry: "Oxford nanopore sequencing enables rapid discovery of single-domain antibodies from phage display libraries." in: BioTechniques, Vol. 65, Issue 6, pp. 351-356, (2018) (PubMed).

    Shukla, Myers, Woods, Gong, Czapar, Commandeur, Huang, Levine, Steinmetz: "Plant viral nanoparticles-based HER2 vaccine: Immune response influenced by differential transport, localization and cellular interactions of particulate carriers." in: Biomaterials, Vol. 121, pp. 15-27, (2017) (PubMed).

    Dakshinamurthy, Mukunda, Prasad Kodaganti, Shenoy, Natarajan, Maliwalave, Halan, Murugesan, Maity: "Charge variant analysis of proposed biosimilar to Trastuzumab." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 46, pp. 46-56, (2017) (PubMed).

    Nath, Flemming, Godat, Urh: "Development of NanoLuc bridging immunoassay for detection of anti-drug antibodies." in: Journal of immunological methods, Vol. 450, pp. 17-26, (2017) (PubMed).

    Ambrosetti, Paoletti, Bosco, Parisse, Scaini, Tagliabue, de Marco, Casalis: "Quantification of Circulating Cancer Biomarkers via Sensitive Topographic Measurements on Single Binder Nanoarrays." in: ACS omega, Vol. 2, Issue 6, pp. 2618-2629, (2017) (PubMed).

    Stojanović, van der Velden, Mulder, Schasfoort, Terstappen: "Quantification of antibody production of individual hybridoma cells by surface plasmon resonance imaging." in: Analytical biochemistry, Vol. 485, pp. 112-8, (2016) (PubMed).

    NDong, Tate, Kett, Batra, Demidenko, Lewis, Hoopes, Gerngross, Griswold: "Tumor Cell Targeting by Iron Oxide Nanoparticles Is Dominated by Different Factors In Vitro versus In Vivo." in: PLoS ONE, Vol. 10, Issue 2, pp. e0115636, (2015) (PubMed).

  • Target
    ErbB2/Her2
    Andere Bezeichnung
    Her2 (ErbB2/Her2 Produkte)
    Synonyme
    CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, Erbb-2, Neu, c-erbB2, c-neu, mKIAA3023, wu:fv70f10, zgc:63601, erb2, erb-b2 receptor tyrosine kinase 2, ERBB2, Erbb2, erbb2
    Hintergrund
    Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2 /neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30 % of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation .
    Molekulargewicht
    70.2 kDa
    NCBI Accession
    NP_004439
    Pathways
    RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Skeletal Muscle Fiber Development
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