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GDNF Family Receptor alpha 1 (GFRA1) (AA 25-424) protein (His tag) Protein

GFRA1 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Produktnummer ABIN2181150
$319.00
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target Alle GFRA1 Proteine anzeigen
    GFRA1
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 25-424
    Spezies
    • 8
    • 4
    • 3
    • 1
    Human
    Quelle
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses GFRA1 Protein ist gelabelt mit His tag.
    Sequenz
    AA 25-424
    Produktmerkmale
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 45.5 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >95 % as determined by SDS-PAGE.
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.
  • Target
    GFRA1
    Andere Bezeichnung
    GFR alpha-1 (GFRA1 Produkte)
    Synonyme
    gdnfr, ret1l, retl1, trnr1, gdnfra, MGC122616, gfr-alpha-1, GDNFR, GDNFRA, GFR-ALPHA-1, RET1L, RETL1, TRNR1, GDNFRALPHA, GFRA1, AU042498, gfralpha1a, zgc:110129, GDNF family receptor alpha 1, glial cell line derived neurotrophic factor family receptor alpha 1, gdnf family receptor alpha 1a, gfra1, GFRA1, Gfra1, gfra1a
    Hintergrund
    GDNF family receptor alpha-1 (GFRA1) is also known as RET ligand 1 (RETL1), TGF-beta-related neurotrophic factor receptor 1 (TRNR1), is a novel glycosylphosphatidylinositol (GPI)-linked cell surface receptor, and belongs to the glial cell line-derived neurotrophic factor (GDNF) receptor subfamily. The GDNF family ligands comprises GDNF, Neurturin (NTN), Artemin, and Persephin. GDNF and NTN are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA1 mediates the association with and activation of the RET tyrosine kinase receptor (RTK), and subsequently initiates the RET signaling pathway. GFR alpha-mediated signaling plays an important role in the survival, differentiation, and migration of central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system, as well as the inflammatory response in some carciniomas.
    Molekulargewicht
    45.5 kDa
    NCBI Accession
    NP_665736
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