ADAM8 Protein (AA 17-497) (His tag)

Produktnummer ABIN2180563

Produktdetails

Target: ADAM8 (ADAM Metallopeptidase Domain 8 (ADAM8))

Protein-Typ: Recombinant

Proteineigenschaft: AA 17-497

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses ADAM8 Protein ist gelabelt mit His tag.

Sequenz: AA 17-497

Produktmerkmale: rh ADAM8 fused with a polyhistidine tag at the C-terminus, has a calculated MW of 71.6 kDa, which migrates as a 120-150 kDa band in DTT-reduced SDS-PAGE due to glycosylation. Two main fragments bands are visible with apparent MW of 67 kDa and 46 kDa respectively in reduced SDS-PAGE as a result of its being prone to proteolytic cleavage.

Reinheit: >90 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 50  mM Tris, 150  mM NaCl, pH 7.5

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.

Antigendetails

Target: ADAM8 (ADAM Metallopeptidase Domain 8 (ADAM8))

Andere Bezeichnung: ADAM8 (ADAM8 Produkte)

Hintergrund: Disintegrin and metalloproteinase domain-containing protein 8 is also known as ADAM8, Cell surface antigen MS2 and CD antigen CD156a, which belongs to the ADAM (a disintegrin and metalloprotease domain) family. ADAM family play a fundamental role in diverse processes such as asthma, development, angiogenesis and cancer through their activities in cell adhesion/fusion, membrane protein shedding, and signal transduction. ADAM8 / CD156a contains 1 disintegrin domain, 1 EGF-like domain and 1 peptidase M12B domain. ADAM8 / MS2 / CD156a is expressed on neutrophils and monocytes. ADAM8 / MS2 possible involvement in extravasation of leukocytes.

Molekulargewicht: 53.8 kDa

Pathways: Activation of Innate immune Response, M Phase