GDNF Protein (AA 77-211)
Kurzübersicht für GDNF Protein (AA 77-211) (ABIN2017883)
Target
Alle GDNF Proteine anzeigenProtein-Typ
Biologische Aktivität
Spezies
Quelle
Reinheit
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Proteineigenschaft
- AA 77-211
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Produktmerkmale
- ED50 <8 μg /mL, measured in a bioassay using C6 cells.
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Endotoxin-Niveau
- < 0.2 EU/μg, determined by LAL method.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
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Buffer
- Lyophilized after extensive dialysis against PBS.
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Lagerung
- -80 °C
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Informationen zur Lagerung
- Lyophilized recombinant murine GDNF remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Murine GDNF should be stable up to 1 week at 4°C or up to 2 months at -20°C.
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Haltbarkeit
- 6 months
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- GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))
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Hintergrund
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Glial-Derived Neurotrophic Factor, also known as GDNF and ATF-1, is a neurotrophic factor belonging to the TGF-beta family. It is expressed in both central nervous system (CNS) and non-CNS tissues. GDNF signals through a receptor system composed of a RET and one of the four GFR alpha receptors. It promotes the survival and differentiation of dopaminergic neurons, and increases their high-affinity dopamine uptake. In a mouse Parkinson's Disease model, GDNF has been shown to improve bradykinesia, rigidity, and postural instability. GDNF has also been shown to regulate kidney development, spermatogenesis and affect alcohol consumption.
Synonyms: Glial-Derived Neurotrophic Factor, ATF-1 -
Molekulargewicht
- 17-22 kDa, observed by reducing SDS-PAGE.
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UniProt
- P48540
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Pathways
- RTK Signalweg, Synaptic Membrane, Tube Formation, Autophagie, Smooth Muscle Cell Migration
Target
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