Glypican 3 Protein (GPC3)

Produktnummer ABIN1880377

Recombinant Glypican 3-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für Glypican 3 Protein (GPC3) (ABIN1880377)

Target: Glypican 3 (GPC3)

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 95 % by SDS-PAGE

Produktdetails

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM Tris-HCL (pH 8.8 +/- 0.2) with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Lagerung: 4 °C

Antigendetails

Target: Glypican 3 (GPC3)

Andere Bezeichnung: Glypican-3

Hintergrund: Glypican 3, GPC3 is a member of the glypican family that are heparan sulfate proteoglycans that bind to the exocytoplasmic surface of the plasma membrane through a covalent glycosylphosphatidylinositol (GPI) linkage. GPC3 gene contains 8 exons and encompasses approximately 500 kb. It encodes a putative extracellular proteoglycan, glypican 3, that is inferred to play an important role in growth control in embryonic mesodermal tissues in which it is selectively expressed. GPC3 acts as a negative regulator of Hedgehog signaling during mammalian development and that the overgrowth observed in SGBS (Simpson-Golabi-Behmel overgrowth syndrome) patients is, at least in part, the consequence of hyperactivation of the Hedgehog signaling pathway.

Pathways: Glycosaminoglycan Metabolic Process