Amphiregulin Protein (AREG) (AA 101-198)

Produktnummer ABIN1692249

Produktdetails

Target: Amphiregulin (AREG)

Protein-Typ: Recombinant

Proteineigenschaft: AA 101-198

Spezies: Human

Quelle: Escherichia coli (E. coli)

Verwendungszweck: Recombinant Human Amphiregulin/AREG

Sequenz: MSVRVEQVVK PPQNKTESEN TSDKPKRKKK GGKNGKNRRN RKKKNPCNAE FQNFCIHGEC KYIEHLEAVT CKCQQEYFGE RCGEKSMKTH SMIDSSLSK

Produktmerkmale:

Recombinant Human Amphiregulin/AREG

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Handhabung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Lagerung: 4 °C/-20 °C/-80 °C

Informationen zur Lagerung: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Amphiregulin (AREG)

Andere Bezeichnung: Amphiregulin/AREG (AREG Produkte)

Synonyme: AR Protein, CRDGF Protein, SDGF Protein, Sdgf Protein, AREG Protein, AREGB Protein, AREG/SDGF Protein, amphiregulin Protein, AREG Protein, Areg Protein

Hintergrund: Recombinant Human Amphiregulin/AREG is produced with our E. coli expression system. The target protein is expressed with sequence (Ser101-Lys198) of Human AREG.
Amphiregulin (AREG) is a single-pass membrane protein with 252 AAs. AREG belongs to the amphiregulin family, which contains 1 EGF-like domain. AREG is expressed in a variety of tissues including ovary, placenta, lung, kidney, stomach, colon, and breast. It is related to Epidermal Growth Factor (EGF) and Transforming Growth Factor α (TGF-α). As an EGF-related growth factor, AREG interacts with the EGF/TGF-α receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. AREG may also play a protective role in Bleomycin-Induced Pneumopathy.

Molekulargewicht: 11.4 kDa

UniProt: P15514

Pathways: RTK Signalweg, EGFR Signaling Pathway