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IL-18 Protein (Interleukin 18) (AA 37-193) (His tag)

IL18 Spezies: Human Wirt: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Produktnummer ABIN1691766
$385.00
Zzgl. Versandkosten $45.00
Lieferung in 4 Werktagen
  • Target Alle IL-18 (IL18) Proteine anzeigen
    IL-18 (IL18) (Interleukin 18 (IL18))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 37-193
    Spezies
    • 12
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Quelle
    • 23
    • 9
    • 2
    • 1
    • 1
    Human Cells
    Aufreinigungstag / Konjugat
    Dieses IL-18 Protein ist gelabelt mit His tag.
    Verwendungszweck
    Recombinant Human Interleukin-18/IL-18/IL-1F4 (C-6His)
    Sequenz
    YFGKLESKLS VIRNLNDQVL FIDQGNRPLF EDMTDSDCRD NAPRTIFIIS MYKDSQPRGM AVTISVKCEK ISTLSCENKI ISFKEMNPPD NIKDTKSDII FFQRSVPGHD NKMQFESSSY EGYFLACEKE RDLFKLILKK EDELGDRSIM FTVQNEDVDH HHHHH
    Produktmerkmale

    Recombinant Human Interleukin-18/IL-18/IL-1F4 (C-6His)

    Reinheit
    > 95 % as determined by reducing SDS-PAGE.
    Sterilität
    0.2 μm filtered
    Endotoxin-Niveau
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    Handhabung
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    Lagerung
    4 °C/-20 °C/-80 °C
    Informationen zur Lagerung
    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    IL-18 (IL18) (Interleukin 18 (IL18))
    Andere Bezeichnung
    Interleukin-18/IL-18 (IL18 Produkte)
    Synonyme
    Igif, Il-18, IL-18, IGIF, ChIL-18, IL-1g, IL1F4, IL18, interleukin 18, Il18, IL18
    Hintergrund
    Recombinant Human Interleukin-18/IL-18 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Tyr37-Asp193) of Human IL-18 fused with a polyhistidine tag at the C-terminus.
    Interleukin-18 is a secreted protein and it belongs to the IL-1 family. IL-18 is a proinflammatory cytokine and produced by macrophages and other cells. This cytokine can induce the IFN-γ production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-γ (IFN-γ) or type II interferon that plays an important role in activating the macrophages or other cells.
    Molekulargewicht
    23.3 kDa
    UniProt
    Q14116
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome
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