PPM1D Produkte
(Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))
Kategorien
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008].
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Ausgewählte PPM1D Kategorien
PPM1D Antikörper
High quality antibodies with extensive validation data.
PPM1D ELISA Kits
Reliable ELISA kits for a wide range of species.
PPM1D Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene PPM1D Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
ELISA, IF (cc), IHC (p), WB
Validierungen
- (1)
- (3)
Kat. Nr.
ABIN740415
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC, WB
Validierungen
- (3)
Kat. Nr.
ABIN7165942
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, WB
Validierungen
- (3)
Kat. Nr.
ABIN563650
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene PPM1D ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6958950
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6951705
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene PPM1D Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Insect Cells
Validierungen
- (1)
Kat. Nr.
ABIN3086448
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Insect Cells
Validierungen
- (1)
Kat. Nr.
ABIN3130585
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1315909
Menge
2 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren PPM1D Produkten
: "Cisplatin induces HepG2 cell cycle arrest through targeting specific long noncoding RNAs and the p53 signaling pathway." in: Oncology letters, Vol. 12, Issue 6, pp. 4605-4612, (2017) (PubMed).: "p53-Independent expression of wild-type p53-induced phosphatase 1 (Wip1) in methylmethane sulfonate-treated cancer cell lines and human tumors." in: The international journal of biochemistry & cell biology, Vol. 44, Issue 6, pp. 896-904, (2012) (PubMed).
: "HDM2 promotes WIP1-mediated medulloblastoma growth." in: Neuro-oncology, Vol. 14, Issue 4, pp. 440-58, (2012) (PubMed).
: "p16Ink4a suppression of lung adenocarcinoma by Bmi-1 in the presence of p38 activation." in: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Vol. 6, Issue 3, pp. 423-31, (2011) (PubMed).
: "Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation." in: The Journal of biological chemistry, Vol. 285, Issue 12, pp. 9067-76, (2010) (PubMed).
: "Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair." in: The Journal of biological chemistry, Vol. 285, Issue 17, pp. 12935-47, (2010) (PubMed).
: "Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway." in: Cancer research, Vol. 70, Issue 18, pp. 7176-86, (2010) (PubMed).
: "The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair." in: DNA repair, Vol. 9, Issue 7, pp. 813-23, (2010) (PubMed).
: "Nuclear factor-kappaB (NF-kappaB) is a novel positive transcriptional regulator of the oncogenic Wip1 phosphatase." in: The Journal of biological chemistry, Vol. 285, Issue 8, pp. 5249-57, (2010) (PubMed).
: "BRCA1-IRIS overexpression abrogates UV-induced p38MAPK/p53 and promotes proliferation of damaged cells." in: Oncogene, Vol. 29, Issue 38, pp. 5274-85, (2010) (PubMed).
Synonyme und alternative Namen zu PPM1D
protein phosphatase, Mg2+/Mn2+ dependent 1D (PPM1D), protein phosphatase 1D magnesium-dependent, delta isoform (Ppm1d), protein phosphatase, Mg2+/Mn2+ dependent, 1D (Ppm1d), protein phosphatase, Mg2+/Mn2+ dependent 1D L homeolog (ppm1d.L), protein phosphatase, Mg2+/Mn2+ dependent, 1Da (ppm1da), AV338790, PP2C-DELTA, ppm1d, WIP1, Wip1, wu:fj44c08, zgc:55836, zgc:77316Bezeichner auf Proteinebene für PPM1D
- protein phosphatase 1D
- protein phosphatase 1D magnesium-dependent, delta isoform
- protein phosphatase 2C delta isoform
- protein phosphatase Wip1
- wild-type p53-induced phosphatase 1
- PP2C-delta
- p53-induced protein phosphatase 1
- protein phosphatase 2C isoform delta
- protein phosphatase magnesium-dependent 1 delta
- protein phosphatase, Mg2+/Mn2+ dependent 1D L homeolog
- protein phosphatase, Mg2+/Mn2+ dependent, 1D
- protein phosphatase 1D magnesium-dependent, delta
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