anti-Apelin (APLN) Antikörper

Zebrafish Apelin (APLN) Interaktionspartner

1. Apelin signaling regulates lymphatic development by promoting serine-threonine kinase Akt/protein kinase B (zeige AKT1 Antikörper) activity in a VEGF-C (zeige VEGFC Antikörper)/VEGF receptor (zeige FLT1 Antikörper) 3-independent manner during zebrafish embryogenesis.

2. Apelin knockdown inhibits both hypoxia-induced endothelial cell proliferation in vitro and hypoxia-induced vessel regeneration in the caudal (zeige CAD Antikörper) fin regeneration of zebrafish.

Mouse (Murine) Apelin (APLN) Interaktionspartner

1. apelin effects on dynamic mechanical characteristics of single ventricular cardiomyocytes

2. Study shows that apelin-13 ameliorates chronic normobaric hypoxia-induced anxiety-like behavior in mice. Anxiolytic effects of apelin-13 might be associated with an inhibition of NF-kappaB (zeige NFKB1 Antikörper) and microglial activation in the hippocampus.

3. Results revealed that apelin-13 attenuated brain edema and reduced cellular death by suppressing apoptosis after intracerebral hemorrhage in mice.

4. Apelin-36-[L28C(30kDa (zeige TAF10 Antikörper)-PEG (zeige PAEP Antikörper))] provides a starting point for the development of diabetes therapeutics that are devoid of the blood pressure effects associated with canonical APJ (zeige APLNR Antikörper) activation

5. miR (zeige MLXIP Antikörper)-503 promotes cardiac fibrosis via miR (zeige MLXIP Antikörper)-503-Apelin-13-TGF-beta (zeige TGFB1 Antikörper)-CTGF (zeige CTGF Antikörper)-collagen production pathway.

6. Apelin directly interferes with thrombin-mediated signaling pathways and platelet activation, secretion, and aggregation, but not with ADP and thromboxane A2-mediated pathways.

7. Apelin regulates inflammatory response, diminishes inflammatory remote organ damage and improves survival in an experimental model of burn sepsis, which is at least partly mediated by a phosphatidylinositol 3-kinase/protein kinase B (zeige AKT1 Antikörper) dependent pathway.

8. apelin is a potential activator of inflammation factors through the PI3K/Akt (zeige AKT1 Antikörper) and Erk (zeige EPHB2 Antikörper) signaling pathway and is potential therapeutically relevant to inflammatory responses of microglia cells

9. we showed the effect of Apelin on RAW264.7 macrophage under normal and hypoxic condition, which could further influence the angiogenesis and inflammation process that promoted by macrophages.

10. PDL- and Cer-induced CP resulted in increased production of the pancreatic BMP2, apelin, and PTHrP signaling systems and that significant cross talk occurred among pancreatic BMP2, apelin, and PTHrP

Cow (Bovine) Apelin (APLN) Interaktionspartner

1. APJ receptor (zeige APLNR Antikörper) in granulosa cells and both apelin and the APJ receptor (zeige APLNR Antikörper) in theca tissues are expressed in bovine ovary.

2. The data suggest that apelin/APJ (zeige APLNR Antikörper) system is involved in the mechanism regulating angiogenesis during follicle maturation as well as during corpora lutea formation and function in the bovine ovary.

Human Apelin (APLN) Interaktionspartner

1. Studies suggest that apelin/APJ (zeige APLNR Antikörper) system may be applied to the treatment of cancers by regulating apoptosis, which may play a vital role in anticancer therapy [review].

2. miR (zeige MLXIP Antikörper)-497 contributes to oxLDL-induced lipid deposition in macrophages largely via targeting of apelin.

3. we have identified APLN as putative predictive bvz biomarker in CRC (zeige CALR Antikörper) patients. High APLN levels predict a poor response to bvz therapy in CRC (zeige CALR Antikörper).

4. Apelin-12 influences troponin I levels in the acute phase of STEMI, whereas during the non-acute phase, low apelin levels were associated with a high rate of MACE.

5. Apelin concentrations are associated with altered plaque stability mediator levels and atherosclerosis in patients with rheumatoid arthritis. These relations are partially dependent on population origin and systemic inflammatory status.

6. APLN and APLNR (zeige APLNR Antikörper) are present in human ovarian cells and APLN increases IGF1 (zeige IGF1 Antikörper)-induced steroidogenesis in granulosa cells through an increase in HSD3B (zeige HSD3B1 Antikörper) protein expression and activation of the MAPK3 (zeige MAPK3 Antikörper)/1 and Akt (zeige AKT1 Antikörper) pathways. Therefore, APLN and APLNR (zeige APLNR Antikörper) may play a role in human follicular development and the pathogenesis of PCOS.

7. Apelin levels mirror the cardiovascular changes seen in pregnancy. Serum and placental apelin levels are decreased in intrauterine growth restriction .

8. Reduced apelin levels may enhance vasoconstriction to influence high BP and heart's workload in EH and ACS.

9. Our data suggest that tumor Apelin can be used as a marker to evaluate clinical characteristics and predict prognosis in GC patients.

10. The apelin/APLNR (zeige APLNR Antikörper) axis regulates cholangiocarcinoma cell proliferation and tumor angiogenesis.

Pig (Porcine) Apelin (APLN) Interaktionspartner

1. Apelin and its receptor (APJ (zeige APLNR Antikörper)) appear to regulate ovarian follicular functions such as steroidogenesis and proliferation via APJ (zeige APLNR Antikörper) activation and different signaling pathways.

2. Pig Apelin mRNA was sequenced.