anti-SIVA1 (SIVA1) Antikörper

Human SIVA1, Apoptosis-Inducing Factor (SIVA1) Interaktionspartner

1. Loss of SIVA1 expression is associated with nasopharyngeal carcinoma.

2. These findings collectively reveal a novel role for the p53 (zeige TP53 Antikörper) target gene SIVA both in regulating metabolism and in enabling tumorigenesis, independently of p53 (zeige TP53 Antikörper).

3. Functional test demonstrated that Siva1 significantly inhibited the invasion and migration of HCT116 cells.

4. electrical stimulation -inducible SIVA1 modulates p53 (zeige TP53 Antikörper) activities in proliferating keratinocytes, and exogenous electrical stimulation affects p53 (zeige TP53 Antikörper)/HDM2/SIVA1 axis leading to increased proliferation during re-epithelialization

5. SIVA1 interacts with RAD18 (zeige RAD18 Antikörper) and serves as a molecular bridge between RAD18 (zeige RAD18 Antikörper) and PCNA (zeige PCNA Antikörper), thus targeting the E3 ligase activity of RAD18 (zeige RAD18 Antikörper) onto PCNA (zeige PCNA Antikörper).

6. Siva1 promotes the ubiquitination and degradation of ARF, which in turn affects the stability of p53 (zeige TP53 Antikörper).

7. Upon stimulation of thromboxane A2, degradation of Siva1 is impeded, resulting in an accumulation of the protein, which translocates from the nucleus to the cytosol.

8. negative regulator of IL-2 (zeige ZEB1 Antikörper) gene expression in Treg cells

9. Data show that low levels of Siva1 and Ser16-phosphorylated stathmin (zeige STMN1 Antikörper) correlate with high metastatic states of breast cancer cells.

10. These findings suggest that the caspase (zeige CASP3 Antikörper)-dependent pathway for induction of apoptosis is involved in Siva-1-mediated influenza A virus replication.

Mouse (Murine) SIVA1, Apoptosis-Inducing Factor (SIVA1) Interaktionspartner

1. These findings collectively reveal a novel role for the p53 (zeige TP53 Antikörper) target gene SIVA both in regulating metabolism and in enabling tumorigenesis, independently of p53 (zeige TP53 Antikörper).

2. Data indicate that p53 (zeige TP53 Antikörper) target Siva is pivotal in regulating apoptosis in the pathology of renal ischemia reperfusion injury.

3. SIVA is a direct transcriptional target for the tumor suppressors p53 (zeige TP53 Antikörper) and E2F1 (zeige E2F1 Antikörper)

4. Siva's expression pattern suggests that it plays an instructive role in apoptosis, and accordingly, we demonstrate that Siva is essential for p53 (zeige TP53 Antikörper)-dependent apoptosis in cerebellar granule neurons.

5. lysophosphatidic acid 2 (zeige PTOV1 Antikörper) receptor mediates down-regulation of Siva-1 to promote cell survival

6. Data show that SLIMMER (zeige FHL1 Antikörper) delayed Siva-1-dependent apoptosis in C2C12 myoblasts.