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SIVA1 Antikörper (N-Term)

SIVA1 Reaktivität: Human, Maus WB, IF, EIA Wirt: Huhn Polyclonal unconjugated
Produktnummer ABIN1450104
  • Target Alle SIVA1 Antikörper anzeigen
    SIVA1 (SIVA1, Apoptosis-Inducing Factor (SIVA1))
    Bindungsspezifität
    • 8
    • 2
    • 2
    • 1
    • 1
    N-Term
    Reaktivität
    • 21
    • 4
    • 1
    Human, Maus
    Wirt
    • 10
    • 10
    • 1
    Huhn
    Klonalität
    • 15
    • 6
    Polyklonal
    Konjugat
    • 17
    • 2
    • 1
    • 1
    Dieser SIVA1 Antikörper ist unkonjugiert
    Applikation
    • 15
    • 9
    • 7
    • 6
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, Mouse.
    Aufreinigung
    Affinity chromatography purified via peptide column
    Immunogen
    16 amino acid synthetic peptide near the amino terminus of human SIVA
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  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % Sodium Azide as preservative
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    SIVA1 (SIVA1, Apoptosis-Inducing Factor (SIVA1))
    Andere Bezeichnung
    SIVA1 / SIVA (SIVA1 Produkte)
    Synonyme
    CD27BP antikoerper, SIVA antikoerper, Siva-1 antikoerper, Siva-2 antikoerper, CD27bp antikoerper, Siva antikoerper, SIVA1 apoptosis inducing factor antikoerper, SIVA1, apoptosis-inducing factor antikoerper, SIVA1 antikoerper, Siva1 antikoerper
    Hintergrund
    SIVA plays an important role in the apoptotic pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. SIVA is a small cysteine-rich protein with a unique N-terminal amphipathic helical region, a death domain homology region (DDHR) and a C-terminal cysteine-rich B-box-like or zinc-finger-like structure. The DDHR domain binds to CD27 and induces apoptosis in T cells through a caspase-dependent mitochondrial pathway. SIVA inhibits BCL2L1 isoform Bcl-xL anti-apoptotic activity and inhibits activation of NFk-B and promotes T-cell receptor-mediated apoptosis. SIVA represents a potential therapeutic target for the treatment of neuronal cell death diseases.Synonyms: Apoptosis regulatory protein Siva, CD27-binding protein, CD27BP
    Gen-ID
    10572
    NCBI Accession
    NP_068355
    Pathways
    Positive Regulation of Endopeptidase Activity
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