SIVA1 Antikörper (N-Term)

Produktnummer ABIN6991621

Dieser Huhn Polyklonal Antikörper detektiert spezifisch SIVA1 in WB, ELISA und IF. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für SIVA1 Antikörper (N-Term) (ABIN6991621)

Target: SIVA1 (SIVA1, Apoptosis-Inducing Factor (SIVA1))

Reaktivität: Human, Maus

Wirt: Huhn

Klonalität: Polyklonal

Konjugat: Dieser SIVA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-SIVA1 Antikörper

Bindungsspezifität: N-Term

Aufreinigung: SIVA Antibody is affinity chromatography purified via peptide column.

Immunogen: SIVA antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human SIVA. The immunogen is located within the first 50 amino acids of SIVA.

Isotyp: IgY

Anwendungsinformationen

Applikationshinweise: SIVA antibody can be used for detection of EPAC1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunofluorescence starting at 20 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: SIVA Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: SIVA antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu SIVA1

Target: SIVA1 (SIVA1, Apoptosis-Inducing Factor (SIVA1))

Andere Bezeichnung: SIVA

Hintergrund: SIVA Antibody: SIVA plays an important role in the apoptotic pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. SIVA is a small cysteine-rich protein with a unique N-terminal amphipathic helical region, a death domain homology region (DDHR) and a C-terminal cysteine-rich B-box-like or zinc-finger-like structure. The DDHR domain binds to CD27 and induces apoptosis in T cells through a caspase-dependent mitochondrial pathway. SIVA inhibits BCL2L1 isoform Bcl-xL anti-apoptotic activity and inhibits activation of NFκ,-B and promotes T-cell receptor-mediated apoptosis. SIVA represents a potential therapeutic target for the treatment of neuronal cell death diseases.

Gen-ID: 10572

NCBI Accession: NP_068355

UniProt: O15304

Pathways: Positive Regulation of Endopeptidase Activity