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Toll-Like Receptor 4 (TLR4) (Middle Region) Peptid

TLR4 Reaktivität: Human Wirt: Synthetic BP, WB, IHC
Produktnummer ABIN985137
  • Target Alle TLR4 Produkte
    TLR4 (Toll-Like Receptor 4 (TLR4))
    Protein Region
    Middle Region
    Spezies
    Human
    Quelle
    • 5
    Synthetic
    Applikation
    Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
    Sequenz
    LGEFRNEGNL EKFDKSALEG LCNLTIEEFR LAYLDYYLDD IIDLFNCLTN
    Produktmerkmale
    This is a synthetic peptide designed for use in combination with anti-TLR4 Antibody(ARP59041_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Aufreinigung
    Purified
  • Applikationshinweise
    Each Investigator should determine their own optimal working dilution for specific applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Konzentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    TLR4 (Toll-Like Receptor 4 (TLR4))
    Synonyme
    ARMD10 Peptide, CD284 Peptide, TLR-4 Peptide, TOLL Peptide, Lps Peptide, Ly87 Peptide, Ran/M1 Peptide, Rasl2-8 Peptide, toll like receptor 4 Peptide, toll-like receptor 4 Peptide, TLR4 Peptide, Tlr4 Peptide
    Hintergrund
    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain.

    Alias Symbols: ARMD10, CD284, TOLL, hToll

    Protein Interaction Partner: BCL10,BTK,CD14,CNPY4,DEFB4A,HMGB1,HSP90B1,IRAK1,IRAK2,LY96,MAPK8IP3,MYD88,NOX4,RIPK2,RNF216,SIGIRR,SYK,TICAM2,TIRAP,TLR1,TLR5,TOLLIP,ECSIT,LY96,LY96,MYD88,PPP4C,RNF216,SIGIRR,TIRAP,TLR1,TOLLIP

    Protein Size: 839
    Molekulargewicht
    93 kDa
    Gen-ID
    7099
    NCBI Accession
    NM_138554, NP_612564
    UniProt
    O00206
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