Toll-Like Receptor 4 (TLR4) (C-Term) Peptid
Kurzübersicht für Toll-Like Receptor 4 (TLR4) (C-Term) Peptid (ABIN8113969)
Target
Spezies
Quelle
Applikation
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Protein Region
- C-Term
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Verwendungszweck
- TLR4 Peptide - C-terminal region
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Sequenz
- QQVELYRLLS RNTYLEWEDS VLGRHIFWRR LRKALLDGKS WNPEGTVGTG
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Toll-Like Receptor 4 (TLR4) (AA 420-435) peptide (Ovalbumin)
TLR4 Reaktivität: Human Wirt: Synthetic WB, Imm, SDS
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Kommentare
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This is a synthetic peptide designed for use in combination with anti-TLR4 Antibody,. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- TLR4 (Toll-Like Receptor 4 (TLR4))
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Hintergrund
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Background Information: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain.
Alternative Symbols: ARMD10, CD284, TOLL, hToll
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Molekulargewicht
- 93kDa
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Gen-ID
- 7099
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NCBI Accession
- NP_612564
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UniProt
- O00206
Target
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