MHC Class I Polypeptide-Related Sequence A (MICA) (Middle Region) Peptid
MICA
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN5513415
150,78 €
Zzgl. Versandkosten 20,00 € und MwSt
100 μg
Lieferung nach:
Deutschland
Lieferung in 15 bis 22 Werktagen
Kurzübersicht für MHC Class I Polypeptide-Related Sequence A (MICA) (Middle Region) Peptid (ABIN5513415)
Target
MICA
(MHC Class I Polypeptide-Related Sequence A (MICA))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
-
-
Protein Region
- Middle Region
-
Sequenz
- QKEGLHSLQE IRVCEIHEDN STRSSQHFYY DGELFLSQNL ETKEWTMPQS
-
Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-MICA Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
-
-
-
Applikationshinweise
- Optimal working dilution should be determined by the investigator.
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Lyophilized
-
Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Lagerung
- -20 °C
-
Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
-
Hintergrund
-
This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.
Alias Symbols: MIC-A, PERB11.1
Protein Size: 383 -
Gen-ID
- 100507436
-
NCBI Accession
- NM_000247, NP_000238
-
UniProt
- Q29983
Target
-
Sie sind hier:
