(Protein Disulfide Isomerase Family A, Member 3 (PDIA3))
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase\; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq, Jul 2008].
Koivunen, Helaakoski, Annunen, Veijola, Räisänen, Pihlajaniemi, Kivirikko: "ERp60 does not substitute for protein disulphide isomerase as the beta-subunit of prolyl 4-hydroxylase." in: The Biochemical journal, Vol. 316 ( Pt 2), pp. 599-605, (1996) (PubMed).
Bourdi, Demady, Martin, Jabbour, Martin, George, Pohl: "cDNA cloning and baculovirus expression of the human liver endoplasmic reticulum P58: characterization as a protein disulfide isomerase isoform, but not as a protease or a carnitine acyltransferase." in: Archives of biochemistry and biophysics, Vol. 323, Issue 2, pp. 397-403, (1995) (PubMed).
Hirano, Shibasaki, Kato, Sakai, Tanaka, Nishida, Yazaki, Takenawa, Hirai: "Molecular cloning and characterization of a cDNA for bovine phospholipase C-alpha: proposal of redesignation of phospholipase C-alpha." in: Biochemical and biophysical research communications, Vol. 204, Issue 1, pp. 375-82, (1994) (PubMed).
Aliase für PDIA3 Proteine
protein disulfide isomerase family A member 3 (PDIA3) Proteine protein disulfide-isomerase A3 (Tsp_10062) Proteine protein disulfide isomerase associated 3 (Pdia3) Proteine protein disulfide isomerase family A, member 3 (Pdia3) Proteine protein disulfide isomerase family A member 3 (Pdia3) Proteine protein disulfide isomerase family A, member 3 (pdia3) Proteine protein disulfide isomerase family A member 3 S homeolog (pdia3.S) Proteine 1 Proteine 25D3-membrane-associated Proteine 58kDa Proteine ER60 Proteine Erp Proteine ERp57 Proteine erp57 Proteine ERp60 Proteine ERp61 Proteine grp-58 Proteine GRP57 Proteine GRP58 Proteine Grp58 Proteine grp58 Proteine HsT17083 Proteine P58 Proteine PDI Proteine PDI-Q2 Proteine pdia3 Proteine PI-PLC Proteine Plca Proteine PLC[a] Proteine sb:cb825 Proteine