anti-p53 (TP53) Antikörper

Human Tumor Protein P53 (TP53) Interaktionspartner

1. Among the hits, miR (zeige MLXIP Antikörper)-596 was identified as a regulator of p53. The overexpression of miR (zeige MLXIP Antikörper)-596 significantly increased p53 at the protein level, thereby inducing apoptosis.

2. Apoptosis pathways are impaired in fibroblasts from patients with SSc (zeige CYP11A1 Antikörper), leading to chronic fibrosis. Nonetheless, PUMA (zeige BBC3 Antikörper)/p53 pathway may not be involved in dysfunction of apoptosis mechanisms in fibroblasts of patients with SSc (zeige CYP11A1 Antikörper).

3. Low TP53 expression is associated with drug resistance in colorectal cancer.

4. The activation of p38 (zeige CRK Antikörper) in response to low doses of ultraviolet radiation was postulated to be protective for p53-inactive cells. Therefore, MCPIP1 (zeige ZC3H12A Antikörper) may favor the survival of p53-defective HaCaT cells by sustaining the activation of p38 (zeige CRK Antikörper).

5. TP53 missense mutations are associated with castration-resistant prostate cancer.

6. P53 degradation is mediated by COP1 (zeige CARD16 Antikörper) in the breast cancer.

7. Combined inactivation of the XRCC4 (zeige XRCC4 Antikörper) non-homologous end-joining (NHEJ) DNA repair gene and p53 efficiently induces brain tumours with hallmark characteristics of human glioblastoma.

8. A direct link between Y14 (zeige RBM8A Antikörper) and p53 expression and suggests a function for Y14 (zeige RBM8A Antikörper) in DNA damage signaling.

9. TP53 Mutation is associated with Mouth Neoplasms.

10. Cryo-Electron Microscopy studies on p53-bound RNA Polymerase II (Pol II (zeige Pol II Antikörper)) reveal that p53 structurally regulates Pol II (zeige Pol II Antikörper) to affect its DNA binding and elongation, providing new insights into p53-mediated transcriptional regulation.

Pig (Porcine) Tumor Protein P53 (TP53) Interaktionspartner

1. Inhibition of p53 signaling pathway can reverse the cell cycle arrest in G0/G1 phase induced by Porcine epidemic diarrhea virus infection.

2. in a pig model of human familial adenomatous polyposis, p53 plays a role in the early precancerous stages of polyp development

3. Knockdown of p53 led to three outcomes: 1) cell death was attenuated; 2) Tunicamycin-induced redistribution of GRP78 (zeige HSPA5 Antikörper) from the nucleus to the endoplasmic reticulum lumen was recovered; and 3) the endoplasmic reticulum-fluorescence/EGFP-calreticulin (zeige CALR Antikörper) was recovered.

4. This study demonstrated that various expression levels of p53 in porcine fibroblasts could be achieved by gene targeting and RNA interference.

5. SIRT1 (zeige SIRT1 Antikörper), p53 and NF-kappaB (zeige NFKB1 Antikörper) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

6. Taken together,these results demonstrated that Porcine parvovirus infection induced apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated apoptosis pathway.

7. Data indicate that higher hepatic glucocorticoid receptor (GR (zeige NR3C1 Antikörper)) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 and specificity protein 1 (Sp1 (zeige SP1 Antikörper)).

8. Taken together, these results demonstrated that transmissible gastroenteritis virus infection promoted the activation of p38 MAPK (zeige MAPK14 Antikörper) and p53 signalling, and p53 signalling might play a dominant role in the regulation of cell apoptosis.

9. role of transcription factor p53 and the metabolic hormone leptin (zeige LEP Antikörper), in controlling basic functions (proliferation, apoptosis and secretory activity) of ovarian cells

10. differential expression of p53 pathway-related genes accounts for breed-specific skeletal muscle and meat characteristics

Rabbit Tumor Protein P53 (TP53) Interaktionspartner

1. Suppressing expression of p53 was a required event in two assays of proliferative vitreoretinopathy.

2. These results suggest that p38 MAPK (zeige MAPK14 Antikörper) signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 (zeige MAPK14 Antikörper) plays a role by way of stimulating NF-kappaB (zeige NFKB1 Antikörper), p53 and caspase-3 (zeige CASP3 Antikörper) activation.

3. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 and decrease in the antiapoptotic BCl2 (zeige BCL2 Antikörper) proteins.

4. Chronically activated, monomeric PDGFRA (zeige PDGFRA Antikörper) induced prolonged activation of Akt (zeige AKT1 Antikörper) and suppressed the level of p53.

5. In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of TP53 transcripts and protein depending on luteal stage.

Guinea Pig Tumor Protein P53 (TP53) Interaktionspartner

1. P53 may play an important role in impulse noise induced-hair cell apoptosis.

Zebrafish Tumor Protein P53 (TP53) Interaktionspartner

1. Nkx2.5 signaling via activation of Nkx2.5-Calr (zeige CALR Antikörper)-p53 signaling pathway results in cardiac dysfunction and hyperglycemia-induced cardiomyopathy.

2. In the hsf4 (zeige HSF4 Antikörper)(null) fish, both p53 and activated-caspase3 were significantly decreased. Combined with the finding that the denucleation defect could be partially rescued through microinjection of p53, fas (zeige FASN Antikörper) and bax (zeige BAX Antikörper) mRNA into the mutant embryos, we directly proved that HSF4 (zeige HSF4 Antikörper) promotes lens fiber cell differentiation by activating p53 and its downstream regulators

3. p53-target genes in Danio rerio have been identified.

4. Data indicate that genetic inhibition of autophagy promotes tumorigenesis in tumor protein p53 (tp53) mutant.

5. Data suggest that the sensitivity of p53 to expression of an editing-defective tRNA synthetase has a critical role in promoting genome integrity and organismal homeostasis.

6. Transcriptome analysis revealed that SepH deficiency induces an inflammatory response and activates the p53 pathway. Consequently, loss of seph renders larvae susceptible to oxidative stress and DNA damage. Finally, we demonstrate that seph interacts with p53 deficiency in adulthood to accelerate gastrointestinal tumor development

7. results suggest that trim69 (zeige TRIM69 Antikörper) participates in tp53-mediated apoptosis during zebrafish development.

8. mutant Mdm2 (zeige MDM2 Antikörper) was unable to rescue a p53-induced apoptotic phenotype.

9. C/ebpalpha (zeige CEBPA Antikörper) plays a role in liver growth regulation via the p53 pathway.

10. Results demonstrate a novel role of Klf8 (zeige KLF8 Antikörper), achieved via modulation of p53 and met expression, in the maintenance neuronal progenitors and development of Purkinje cells and the proliferation of granule cells in the cerebella of zebrafish embryos

Cow (Bovine) Tumor Protein P53 (TP53) Interaktionspartner

1. The effect of p53 expression on the development of cloned embryos, and its interaction with HDAC1 (zeige HDAC1 Antikörper) and DNMT3A (zeige DNMT3A Antikörper) are reported.

2. Bov-A2 insertion into the TP53 promoter in Antilopinae and Tragelaphini may not only provide a genetic network that regulates mammary involution, but can also answer the need for rapid mammary involution in Savanna antelopes

3. PI3K/Akt (zeige AKT1 Antikörper) and p53 are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

4. Results demonstrate that embryonic developmental potential is related to the time of first cleavage and that p66(shc), but not p53, is up-regulated in early arrested in vitro-produced bovine embryos.

Mouse (Murine) Tumor Protein P53 (TP53) Interaktionspartner

1. In studies of lymphomagenesis, mutant TRP53 drives tumorigenesis primarily through dominant-negative effects, which modulates wild-type TRP53 function in a manner advantageous for neoplastic transformation.

2. p53 deteriorated cardiac functions and cardiac hypertrophy, apoptosis, and fibrosis by partially inhibition of HIF1alpha (zeige HIF1A Antikörper) and VEGF (zeige VEGFA Antikörper).

3. p53 induces miR199a-3p to suppress SOCS7 (zeige SOCS7 Antikörper) for STAT3 (zeige STAT3 Antikörper) activation and renal fibrosis in unilateral urethral obstruction.

4. Knockdown of the Sprr2b gene or inhibition of SPRR2B phosphorylation attenuates USP7 (zeige USP7 Antikörper)/MDM2 (zeige MDM2 Antikörper) binding and p53 degradation, leading to fibroblasts cell cycle arrest.

5. MDMX (zeige MDM4 Antikörper) is an important regulator of p53 DNA binding, which complements the role of MDM2 (zeige MDM2 Antikörper) in regulating p53 level.

6. the disruption of Mdm2 (zeige MDM2 Antikörper)/p53 interaction affects the early-embryonic otic progenitor cells and their descendants.

7. Deletion of NF1 (zeige NF1 Antikörper) leads to mutant oligodendrocyte precursor cell (OPC) expansion through increased proliferation and decreased differentiation, the deletion of p53 impairs OPC senescence. Signaling analysis showed that, while PI3K and MEK (zeige MDK Antikörper) pathways go through stepwise over-activation, mTOR (zeige FRAP1 Antikörper) signaling remains at the basal level in pre-transforming mutant OPCs but is abruptly up-regulated in tumor OPCs.

8. findings uncover a new function of p53 in the regulation of Akt (zeige AKT1 Antikörper) signaling and reveal how p53, ASS1 (zeige ASS1 Antikörper), and Akt (zeige AKT1 Antikörper) are interrelated to each other.

9. Rlip deficiency suppresses spontaneous malignancy in p53(-/-) mice.

10. Obtained results suggest that Wip1 (zeige PPM1D Antikörper) deficiency sensitizes cells to sodium butyrate and to MEK (zeige MDK Antikörper)/ERK (zeige EPHB2 Antikörper) inhibitors independently from Wip1 (zeige PPM1D Antikörper) main target protein - p53. Data acquired give insights into role of Wip1 (zeige PPM1D Antikörper) in cellular responses to treatment with HDAC (zeige HDAC3 Antikörper) and MEK (zeige MDK Antikörper)/ERK (zeige EPHB2 Antikörper) inhibitors.

Xenopus laevis Tumor Protein P53 (TP53) Interaktionspartner

1. The stabilities of the full-length p53 orthologs were marginal and correlated with the temperature of their organism, paralleling the stability of the isolated DNA-binding domains.

2. PP2A:B56{epsilon}, a substrate of caspase-3 (zeige CASP3 Antikörper), regulates p53-dependent and p53-independent apoptosis during development.

3. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53-overexpressed apoptotic embryos. [SAMDC]

4. XFDL156 actively restricts mesodermal differentiation in the presumptive ectoderm by controlling the spatiotemporal responsiveness to p53.

Horse (Equine) Tumor Protein P53 (TP53) Interaktionspartner

1. Expression of p53 and Ki67 (zeige MKI67 Antikörper) and presence or expression of EcPV2 and EcPV3 do not appear to be important prognosticators.

2. The allele frequency in Thoroughbred horse mares at codon 72 in exon 4 was 73.3% Arg/Pro, 17.1% Arg/Arg, 9.6% Pro/Pro. Presence of Arg/Pro was significantly associated with abortion, while Pro/Pro mares had a lower probability of abortion.

Rainbow Trout (Oncorhynchus mykiss) Tumor Protein P53 (TP53) Interaktionspartner

1. levels of p53 in rainbow trout tissues and cell lines reported; detection of high p53 levels in gills may reflect need for elevated checkpoint readiness in a tissue that would be expected to be accessible to genotoxic compounds in the aquatic environment

Goat Tumor Protein P53 (TP53) Interaktionspartner

1. miR (zeige MYLIP Antikörper)-34c expression is p53-dependent in dairy goat male germline stem cells.[p53]

Medaka Tumor Protein P53 (TP53) Interaktionspartner

1. p53 is not essential for tissue self-renewal in developing brain.

2. These results suggest that p53 positively regulates neurogenesis via cell proliferation.