anti-p53 (TP53) Antikörper

Human Tumor Protein P53 (TP53) Interaktionspartner

1. results showed that a) alterations of the p53 and Rb pathways are associated with high proliferation of tumor cells in BUC and b) high expression of cell-cycle proteins is associated with adverse histopathological parameters of these tumors

2. Moreover, under positive p53 expression, low expression of ATM[ataxia telangiectasia mutated] was highly predictive of poor survival in ACC[Adenoid cystic carcinoma] (p=0.017). CONCLUSION: These data indicate that combined assessment of ATM and p53 expression can serve as a useful prognostic marker for assessing survival rate in patients with ACC [Adenoid cystic carcinom]of the salivary glands.

3. These results suggest that the wild type p53 plays a role in regulating ZIP14 (zeige SLC39A14 Antikörper), but not DMT1 (zeige DMRT1 Antikörper) in HepG2 cells.

4. these results suggested that Aloin may induce apoptosis in A549 cells via the ROSmitogen activated protein kinase (zeige CDK7 Antikörper) signaling pathway, with p53 phosphorylation. These results implicate Aloin as a potential therapeutic agent for the treatment of lung cancer.

5. Data demonstrates that p53 inhibits OSX (zeige MID1 Antikörper) binding to their responsive Sp1 (zeige PSG1 Antikörper)/GC-rich (zeige RELB Antikörper) sites in the promoters of their osteogenic target genes, such as IBSP (zeige IBSP Antikörper) or COL1A1 (zeige COL1A1 Antikörper).

6. A two-hit loss involving VHL (zeige VHL Antikörper) predicted for clear-cell renal cell carcinoma (zeige MOK Antikörper)(ccRCC ) and a better prognosis, whereas mutations in PTEN, TP53, or RELN (zeige RELN Antikörper) predicted for Sarcomatoid clear-cell renal cell carcinoma (zeige MOK Antikörper) and worse prognosis.

7. Nongenotoxic p53 activation suppresses mTOR (zeige FRAP1 Antikörper) activity. Moreover, p53 reactivation via RG7388, a second-generation MDM2 (zeige MDM2 Antikörper) inhibitor, strongly enhances the in vivo antitumor activity of temsirolimus

8. Low TP53 expression is associated with hepatocellular carcinoma.

9. Our results suggest that TP53 may be linked with type 2 diabetes mellitus (T2DM). The fluctuations of serum TP53 level may reflect metabolic and oxidative stress associated with chronic hyperglycaemia

10. Vorinostat synergizes with AZD1775 in head and neck squamous cell carcinoma (HNSCC)cells with mutant p53 in vitro and in vivo A strategy combining HDAC (zeige HDAC3 Antikörper) and WEE1 (zeige WEE1 Antikörper) inhibition deserves further clinical investigation in patients with advanced HNSCC.

Pig (Porcine) Tumor Protein P53 (TP53) Interaktionspartner

1. This study demonstrated that various expression levels of p53 in porcine fibroblasts could be achieved by gene targeting and RNA interference.

2. SIRT1 (zeige SIRT1 Antikörper), p53 and NF-kappaB (zeige NFKB1 Antikörper) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

3. Taken together,these results demonstrated that Porcine parvovirus infection induced apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated apoptosis pathway.

4. Data indicate that higher hepatic glucocorticoid receptor (GR (zeige NR3C1 Antikörper)) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 and specificity protein 1 (Sp1 (zeige SP1 Antikörper)).

5. Taken together, these results demonstrated that transmissible gastroenteritis virus infection promoted the activation of p38 MAPK (zeige MAPK14 Antikörper) and p53 signalling, and p53 signalling might play a dominant role in the regulation of cell apoptosis.

6. role of transcription factor p53 and the metabolic hormone leptin (zeige LEP Antikörper), in controlling basic functions (proliferation, apoptosis and secretory activity) of ovarian cells

7. differential expression of p53 pathway-related genes accounts for breed-specific skeletal muscle and meat characteristics

8. CONCLUSION(S): (1) Apoptosis is involved in follicular atresia; (2) Bcl-2 (zeige BCL2 Antikörper) is induced by warm ischemia; and (3) cryopreservation insult does not alter the apoptotic signals with short tissue preparation time.

9. Suppressive effect of FSH (zeige BRD2 Antikörper) and LH on p53 expression and caspase-3 (zeige CASP3 Antikörper) activity with parallel increase in bcl-2 (zeige BCL2 Antikörper) expression and increased P production was observed.

10. p53 signaling might be a major determinant for the replicative senescence in the miniature pig fibroblast cells that have the shorter lifespan and slower growth rate compared to primary domestic pig fibroblast cells in vitro.

Rabbit Tumor Protein P53 (TP53) Interaktionspartner

1. Suppressing expression of p53 was a required event in two assays of proliferative vitreoretinopathy.

2. These results suggest that p38 MAPK (zeige MAPK14 Antikörper) signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 (zeige MAPK14 Antikörper) plays a role by way of stimulating NF-kappaB (zeige NFKB1 Antikörper), p53 and caspase-3 (zeige CASP3 Antikörper) activation.

3. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 and decrease in the antiapoptotic BCl2 (zeige BCL2 Antikörper) proteins.

4. Chronically activated, monomeric PDGFRA (zeige PDGFRA Antikörper) induced prolonged activation of Akt (zeige AKT1 Antikörper) and suppressed the level of p53.

5. In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of TP53 transcripts and protein depending on luteal stage.

Guinea Pig Tumor Protein P53 (TP53) Interaktionspartner

1. P53 may play an important role in impulse noise induced-hair cell apoptosis.

Zebrafish Tumor Protein P53 (TP53) Interaktionspartner

1. Nkx2.5 signaling via activation of Nkx2.5-Calr (zeige CALR Antikörper)-p53 signaling pathway results in cardiac dysfunction and hyperglycemia-induced cardiomyopathy.

2. In the hsf4 (zeige HSF4 Antikörper)(null) fish, both p53 and activated-caspase3 were significantly decreased. Combined with the finding that the denucleation defect could be partially rescued through microinjection of p53, fas (zeige FASN Antikörper) and bax (zeige BAX Antikörper) mRNA into the mutant embryos, we directly proved that HSF4 (zeige HSF4 Antikörper) promotes lens fiber cell differentiation by activating p53 and its downstream regulators

3. p53-target genes in Danio rerio have been identified.

4. Data indicate that genetic inhibition of autophagy promotes tumorigenesis in tumor protein p53 (tp53) mutant.

5. Data suggest that the sensitivity of p53 to expression of an editing-defective tRNA synthetase has a critical role in promoting genome integrity and organismal homeostasis.

6. Transcriptome analysis revealed that SepH deficiency induces an inflammatory response and activates the p53 pathway. Consequently, loss of seph renders larvae susceptible to oxidative stress and DNA damage. Finally, we demonstrate that seph interacts with p53 deficiency in adulthood to accelerate gastrointestinal tumor development

7. results suggest that trim69 (zeige TRIM69 Antikörper) participates in tp53-mediated apoptosis during zebrafish development.

8. mutant Mdm2 (zeige MDM2 Antikörper) was unable to rescue a p53-induced apoptotic phenotype.

9. C/ebpalpha (zeige CEBPA Antikörper) plays a role in liver growth regulation via the p53 pathway.

10. Results demonstrate a novel role of Klf8 (zeige KLF8 Antikörper), achieved via modulation of p53 and met expression, in the maintenance neuronal progenitors and development of Purkinje cells and the proliferation of granule cells in the cerebella of zebrafish embryos

Cow (Bovine) Tumor Protein P53 (TP53) Interaktionspartner

1. The effect of p53 expression on the development of cloned embryos, and its interaction with HDAC1 (zeige HDAC1 Antikörper) and DNMT3A (zeige DNMT3A Antikörper) are reported.

2. Bov-A2 insertion into the TP53 promoter in Antilopinae and Tragelaphini may not only provide a genetic network that regulates mammary involution, but can also answer the need for rapid mammary involution in Savanna antelopes

3. PI3K/Akt (zeige AKT1 Antikörper) and p53 are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

4. Results demonstrate that embryonic developmental potential is related to the time of first cleavage and that p66(shc), but not p53, is up-regulated in early arrested in vitro-produced bovine embryos.

Mouse (Murine) Tumor Protein P53 (TP53) Interaktionspartner

1. Activation of p53 blocks neural differentiation of miRNA-deficient pluripotent stem cells.

2. p53 mediates the regulation of bile acid disposition and attenuates cholic acid-induced cholestasis in mice

3. Data demonstrates that p53 inhibits OSX (zeige SP7 Antikörper) binding to their responsive Sp1 (zeige SP1 Antikörper)/GC-rich (zeige RELB Antikörper) sites in the promoters of their osteogenic target genes, such as IBSP (zeige IBSP Antikörper) or COL1A1 (zeige COL1A1 Antikörper).

4. A summary of current knowledge of p53-mediated tumor-suppressive mechanisms gleaned from in vivo studies in mouse models (review).

5. Increased Cdc7 (zeige CDC7 Antikörper)-dependent replication initiation is a hallmark of p53 gain-of function mutations in lung adenocarcinoma.

6. Aging mouse models have revealed the complexity of the p53-Mdm2 (zeige MDM2 Antikörper) axis and have solidly placed the p53 network as being key to many aspects of both pathological aging conditions and normal aging (review).

7. In myoblasts silenced for the expression of muscle regulatory transcription factor MyoD (zeige MYOD1 Antikörper), tumor suppressor p53 binding to the PUMA (zeige BBC3 Antikörper) promoter is diminished in response to culture in differentiation medium.

8. Study provides evidence that high expression of CLDN6 (zeige CLDN6 Antikörper) confers chemoresistance on breast cancer which is mediated by GSTP1 (zeige GSTP1 Antikörper), the activity of which is regulated by p53.

9. AKI was associated with the upregulation of several known p53 target genes. This was attenuated in p53-KO mice. In human renal tubular epithelial cell line, vancomycin induced p53 accumulation. p53 was associated with the development of VAN (zeige SLC11A2 Antikörper)-induced AKI through upregulation of miR (zeige MLXIP Antikörper)-192-5p.

10. Recent work in a TP53(-/-)BRCA1-mutant murine breast cancer model indicates that double blockade with two immune checkpoint inhibitors increases the number of tumor-infiltrating lymphocytes and overall survival after DNA damaging chemotherapy, whereas single blockade does not

Xenopus laevis Tumor Protein P53 (TP53) Interaktionspartner

1. The stabilities of the full-length p53 orthologs were marginal and correlated with the temperature of their organism, paralleling the stability of the isolated DNA-binding domains.

2. PP2A:B56{epsilon}, a substrate of caspase-3 (zeige CASP3 Antikörper), regulates p53-dependent and p53-independent apoptosis during development.

3. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53-overexpressed apoptotic embryos. [SAMDC]

4. XFDL156 actively restricts mesodermal differentiation in the presumptive ectoderm by controlling the spatiotemporal responsiveness to p53.

Horse (Equine) Tumor Protein P53 (TP53) Interaktionspartner

1. Expression of p53 and Ki67 (zeige MKI67 Antikörper) and presence or expression of EcPV2 and EcPV3 do not appear to be important prognosticators.

2. The allele frequency in Thoroughbred horse mares at codon 72 in exon 4 was 73.3% Arg/Pro, 17.1% Arg/Arg, 9.6% Pro/Pro. Presence of Arg/Pro was significantly associated with abortion, while Pro/Pro mares had a lower probability of abortion.

Rainbow Trout (Oncorhynchus mykiss) Tumor Protein P53 (TP53) Interaktionspartner

1. levels of p53 in rainbow trout tissues and cell lines reported; detection of high p53 levels in gills may reflect need for elevated checkpoint readiness in a tissue that would be expected to be accessible to genotoxic compounds in the aquatic environment

Goat Tumor Protein P53 (TP53) Interaktionspartner

1. miR (zeige MYLIP Antikörper)-34c expression is p53-dependent in dairy goat male germline stem cells.[p53]

Medaka Tumor Protein P53 (TP53) Interaktionspartner

1. p53 is not essential for tissue self-renewal in developing brain.

2. These results suggest that p53 positively regulates neurogenesis via cell proliferation.