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Human MDM2 Protein expressed in Wheat germ - ABIN1310600
Zhang, Zhong, Chen: LC-MS/MS-based targeted proteomics quantitatively detects the interaction between p53 and MDM2 in breast cancer. in Journal of proteomics 2016
The MDM2 T309G polymorphism GG genotype and the TG+GG combination may be risk factors for breast cancer in our Turkish population.
Human blastocyst-secreted miR (zeige MLXIP Proteine)-661 reduces endometrial epithelial cell adhesion via downregulation of MDM2, regulating endometrial-blastocyst adhesion, and implantation.
MDM2 is associated with giant cell tumor of bone recurrence, which might serve as biomarker for giant cell tumor of bone recurrence
The ID genotype of the MDM2 I/D polymorphism was associated with a lower risk of SLE. There was no association between MDM2 T309G polymorphism and SLE.
The present study demonstrated that the oncostatic effects of melatonin on SGC (zeige SGCB Proteine)-7901 GC cells are mediated via the blockade of the AKT (zeige AKT1 Proteine)/MDM2 intracellular pathway.
Nongenotoxic p53 (zeige TP53 Proteine) activation suppresses mTOR (zeige FRAP1 Proteine) activity. Moreover, p53 (zeige TP53 Proteine) reactivation via RG7388, a second-generation MDM2 inhibitor, strongly enhances the in vivo antitumor activity of temsirolimus
Overview of the connections between p53-MDM2 axis and huma (zeige TP53 Proteine)n aging disorders and aging-related pathwa (zeige TP53 Proteine)ys (review).
The Role of MDM2 in genome stability/instability and DNA repair is reviewed.
Notch1 (zeige NOTCH1 Proteine) signaling is an essential downstream pathway of MDM2 in mediating high glucose-induced mitotic catastrophe in podocytes.
our data confirmed the individual susceptibility to BC resulting from polymorphic markers of DNA repair genes (XRCC1 (zeige XRCC1 Proteine)), apoptosis genes (TP53 (zeige TP53 Proteine)), as well as of apoptosis inhibition genes (MDM2).
results suggest overexpression of MDM2 is closely linked to inhibition of p53 (zeige TP53 Proteine)-dependent apoptosis of Theileria parva (zeige PARVA Proteine)-infected lymphocytes; aberrant expression of host lymphocyte MDM2 induced by cytoplasmic existence of T. parva (zeige PARVA Proteine), directly and/or indirectly, is associated with aspects of this type of transformation of T. parva (zeige PARVA Proteine)-infected lymphocytes
mutant Mdm2 was unable to rescue a p53 (zeige TP53 Proteine)-induced apoptotic phenotype.
Data indicate that knockdown of the Mdm2 and Mdm4 (zeige MDM4 Proteine) caused dramatic accumulation of mutant p53 protein (zeige TP53 Proteine).
Together with p53 (zeige TP53 Proteine), provides an experimental model for characterizing drugs and genes that affect p53 (zeige TP53 Proteine) signaling.
Data show that liver-specific expression of p53 (zeige TP53 Proteine)-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish.
the MDM2-p53 (zeige TP53 Proteine)-PC signalling axis links mitochondrial metabolism to insulin (zeige INS Proteine) secretion and glucose homeostasis, and could represent a therapeutic target in diabetes.
Selective dysregulation of Mdm2 and Mdm4 (zeige MDM4 Proteine) alternative splicing underlies p53 (zeige TP53 Proteine) anti-repression and motor neuron death in a mouse model of spinal muscular atrophy.
Aging mouse models have revealed the complexity of the p53 (zeige TP53 Proteine)-Mdm2 axis and have solidly placed the p53 (zeige TP53 Proteine) network as being key to many aspects of both pathological aging conditions and normal aging (review).
The results indicated that simultaneously knocking down MDM2 and overexpressing p53 (zeige TP53 Proteine) was able to inhibit proliferation and induce G1 cell cycle arrest in H1299 cells, compared with either alone.
These results illustrate the importance of the cooperative activities of p53 (zeige TP53 Proteine) and Mdm2 in a network of miRNAs that function to impose a barrier against aberrant cardiomyocyte cell cycle re-entry to maintain cardiac homeostasis.
c-Abl (zeige ABL1 Proteine) phosphorylation of Mdm2 has a role in regulation of p53 (zeige TP53 Proteine) tumor suppression and bone marrow failure
Bre (zeige BRE Proteine) enhances osteoblastic differentiation by promoting the Mdm2-mediated degradation of p53 (zeige TP53 Proteine).
genetic and biochemical data support a role for Mdm2 in cardiac growth control through the regulation of p53 (zeige TP53 Proteine), the Pgc-1 family of transcriptional coactivators and the pivotal antioxidant Pink1 (zeige PINK1 Proteine)
The availability of large-scale genomic profiling datasets, like those from The Cancer Genome Atlas Research Network, have provided the opportunity to evaluate the consequences of MDM2 amplification and SNP inheritance across high-quality tumor samples from diverse cancer indications. [review]
findings document contrasting effects of ATM (zeige ATM Proteine)-Mdm2 signaling on p53 (zeige TP53 Proteine) tumor suppression and reveal that destabilizing Mdm2 by promoting its phosphorylation by ATM (zeige ATM Proteine) would be effective in treating oncogene (zeige RAB1A Proteine)-induced malignancies.
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.
E3 ubiquitin-protein ligase Mdm2
, Mdm2, p53 E3 ubiquitin protein ligase homolog
, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein
, double minute 2, human homolog of; p53-binding protein
, oncoprotein Mdm2
, Mdm2 p53 binding protein homolog
, double minute 2 protein
, p53-binding protein Mdm2
, MDM2 alpha
, double minute 2 homolog
, double minute 2
, MDM2-like protein
, transformed mouse 3T3 cell double minute 2
, murine double minute 2 homolog