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Human MDM2 Protein expressed in Wheat germ - ABIN1310600
Zhang, Zhong, Chen: LC-MS/MS-based targeted proteomics quantitatively detects the interaction between p53 and MDM2 in breast cancer. in Journal of proteomics 2016
Our study showed that miR (zeige MLXIP Proteine)-145 suppressed MDM2 expression, which subsequently influenced the p53 (zeige TP53 Proteine)-related cell growth pattern in pterygial epithelium. The regulatory miR (zeige MLXIP Proteine)-145/MDM2-p53 (zeige TP53 Proteine) loop can serve as a potential target for treatment of pterygium.
In contrast to other deubiquitinating enzymes (DUBs) that have been previously implicated in the regulation of Mdm2 protein stability, USP48 (zeige USP48 Proteine) did not induce Mdm2 stabilization by significantly reducing Mdm2 ubiquitination levels.
MDM2 rs937283 A > G variant is associated with lung and gastric cancer.
No associations were found between MDM2 SNP309 and either of two FSH (zeige BRD2 Proteine)/LH groups.
MDM2 promoter variants play a role in determining the risk of recurrence of squamous cell carcinoma of oropharynx
In silico molecular docking and dynamics studies with MDM2-p53 (zeige TP53 Proteine) protein revealed that HTMF was more potent compound that could inhibit the binding of MDM2 with p53 (zeige TP53 Proteine) and, therefore, could trigger apoptosis in cancer cell.
Our findings suggested that RBM38 (zeige RBM38 Proteine) may be a core contributor in stabilizing the p53 (zeige TP53 Proteine)-mdm2 loop function to prevent hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) and a potential novel target to provide a therapeutic strategy for HCC (zeige FAM126A Proteine) by inhibiting mdm2 and rescuing p53 (zeige TP53 Proteine) from inactivation.
As shown in human MDM2-ALT1 (zeige ALT Proteine)-expressing p53 (zeige TP53 Proteine) null transgenic mice, MDM2-ALT1 (zeige ALT Proteine) can direct rhabdomyosarcoma (RMS) tumor formation recapitulating many of the histological and immunohistochemical features of fusion-negative RMS.
We demonstrate that extraskeletal osteosarcoma (ESOS) may include at least two small subsets: an MDM2-amplified deep soft-tissue ESOS and an H3K27me3-deficient organ-based ESOS
miR (zeige MLXIP Proteine)-518 acted as a new tumor suppressor by targeting MDM2 gene and trigger apoptosis in vivo and in vitro.
results suggest overexpression of MDM2 is closely linked to inhibition of p53 (zeige TP53 Proteine)-dependent apoptosis of Theileria parva (zeige PARVA Proteine)-infected lymphocytes; aberrant expression of host lymphocyte MDM2 induced by cytoplasmic existence of T. parva (zeige PARVA Proteine), directly and/or indirectly, is associated with aspects of this type of transformation of T. parva (zeige PARVA Proteine)-infected lymphocytes
mutant Mdm2 was unable to rescue a p53 (zeige TP53 Proteine)-induced apoptotic phenotype.
Data indicate that knockdown of the Mdm2 and Mdm4 (zeige MDM4 Proteine) caused dramatic accumulation of mutant p53 protein (zeige TP53 Proteine).
Together with p53 (zeige TP53 Proteine), provides an experimental model for characterizing drugs and genes that affect p53 (zeige TP53 Proteine) signaling.
Data show that liver-specific expression of p53 (zeige TP53 Proteine)-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish.
the disruption of Mdm2/p53 (zeige TP53 Proteine) interaction affects the early-embryonic otic progenitor cells and their descendants.
E2F6 (zeige E2F6 Proteine) suppresses Mdm2 expression in cells harboring the SNP309G allele but not the SNP309T allele.
the MDM2-p53 (zeige TP53 Proteine)-PC signalling axis links mitochondrial metabolism to insulin (zeige INS Proteine) secretion and glucose homeostasis, and could represent a therapeutic target in diabetes.
Selective dysregulation of Mdm2 and Mdm4 (zeige MDM4 Proteine) alternative splicing underlies p53 (zeige TP53 Proteine) anti-repression and motor neuron death in a mouse model of spinal muscular atrophy.
Aging mouse models have revealed the complexity of the p53 (zeige TP53 Proteine)-Mdm2 axis and have solidly placed the p53 (zeige TP53 Proteine) network as being key to many aspects of both pathological aging conditions and normal aging (review).
The results indicated that simultaneously knocking down MDM2 and overexpressing p53 (zeige TP53 Proteine) was able to inhibit proliferation and induce G1 cell cycle arrest in H1299 cells, compared with either alone.
These results illustrate the importance of the cooperative activities of p53 (zeige TP53 Proteine) and Mdm2 in a network of miRNAs that function to impose a barrier against aberrant cardiomyocyte cell cycle re-entry to maintain cardiac homeostasis.
c-Abl (zeige ABL1 Proteine) phosphorylation of Mdm2 has a role in regulation of p53 (zeige TP53 Proteine) tumor suppression and bone marrow failure
Bre (zeige BRE Proteine) enhances osteoblastic differentiation by promoting the Mdm2-mediated degradation of p53 (zeige TP53 Proteine).
genetic and biochemical data support a role for Mdm2 in cardiac growth control through the regulation of p53 (zeige TP53 Proteine), the Pgc-1 family of transcriptional coactivators and the pivotal antioxidant Pink1 (zeige PINK1 Proteine)
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.
E3 ubiquitin-protein ligase Mdm2
, Mdm2, p53 E3 ubiquitin protein ligase homolog
, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein
, double minute 2, human homolog of; p53-binding protein
, oncoprotein Mdm2
, Mdm2 p53 binding protein homolog
, double minute 2 protein
, p53-binding protein Mdm2
, MDM2 alpha
, double minute 2 homolog
, double minute 2
, MDM2-like protein
, transformed mouse 3T3 cell double minute 2
, murine double minute 2 homolog