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Human MDM2 Protein expressed in Wheat germ - ABIN1310600
Zhang, Zhong, Chen: LC-MS/MS-based targeted proteomics quantitatively detects the interaction between p53 and MDM2 in breast cancer. in Journal of proteomics 2016
our data confirmed the individual susceptibility to BC resulting from polymorphic markers of DNA repair genes (XRCC1 (zeige XRCC1 Proteine)), apoptosis genes (TP53 (zeige TP53 Proteine)), as well as of apoptosis inhibition genes (MDM2).
In multivariate analysis, MDM2/MDM4 (zeige MDM4 Proteine) and EGFR (zeige EGFR Proteine) alterations correlated with time-to-treatment failure (TTF)..Some patients with MDM2 family amplification or EGFR (zeige EGFR Proteine) aberrations had poor clinical outcome and significantly increased rate of tumor growth after single-agent checkpoint (PD-1 (zeige PDCD1 Proteine)/PD-L1 (zeige CD274 Proteine)) inhibitors
Results demonstrate that Mdm2 is extremely important in breast cancer metastases to the lung. Specifically, Mdm2 is important to promote cancer invasiveness via cell migration, angiogenesis, and intravasation.
GG genotype of MDM2 re2279744 showed a statistically significantly increased risk of developing endometrial cancer risk in a Chinese Han population.
GATA4 (zeige GATA4 Proteine) was a transcription factor that activated mouse double minute 2 homolog (MDM2) and B cell lymphoma 2 (BCL2 (zeige BCL2 Proteine)) expression in ALL cells.
Findings of the study confirm that L-THP (zeige UMOD Proteine) resulted in p53 (zeige TP53 Proteine) independent apoptosis via down-regulating XIAP (zeige XIAP Proteine) protein by inhibiting MDM2 associated with proteasome-dependent pathway and increased sensitivity of EU-4 cells against doxorubicin.
MDM2 promoter SNP55 (rs2870820) affects risk of colon cancer but not breast-, lung-, or prostate cancer.
Importantly, these results imply that the Zika virus capsid protein interacts with mouse double-minute-2 homolog (MDM2), which is involved in the P53 (zeige TP53 Proteine)-mediated apoptosis pathway, activating the death of infected neural cells.
The expression levels of Bcl11a and Mdm2, Pten in B-ALL patients with CR were decreased significantly when compared with the healthy control (P < 0.05).
A near-native models of the p53 (zeige TP53 Proteine)-MDM2 complex have been presented.
results suggest overexpression of MDM2 is closely linked to inhibition of p53 (zeige TP53 Proteine)-dependent apoptosis of Theileria parva (zeige PARVA Proteine)-infected lymphocytes; aberrant expression of host lymphocyte MDM2 induced by cytoplasmic existence of T. parva (zeige PARVA Proteine), directly and/or indirectly, is associated with aspects of this type of transformation of T. parva (zeige PARVA Proteine)-infected lymphocytes
mutant Mdm2 was unable to rescue a p53 (zeige TP53 Proteine)-induced apoptotic phenotype.
Data indicate that knockdown of the Mdm2 and Mdm4 (zeige MDM4 Proteine) caused dramatic accumulation of mutant p53 protein (zeige TP53 Proteine).
Together with p53 (zeige TP53 Proteine), provides an experimental model for characterizing drugs and genes that affect p53 (zeige TP53 Proteine) signaling.
Data show that liver-specific expression of p53 (zeige TP53 Proteine)-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish.
The results indicated that simultaneously knocking down MDM2 and overexpressing p53 (zeige TP53 Proteine) was able to inhibit proliferation and induce G1 cell cycle arrest in H1299 cells, compared with either alone.
These results illustrate the importance of the cooperative activities of p53 (zeige TP53 Proteine) and Mdm2 in a network of miRNAs that function to impose a barrier against aberrant cardiomyocyte cell cycle re-entry to maintain cardiac homeostasis.
c-Abl (zeige ABL1 Proteine) phosphorylation of Mdm2 has a role in regulation of p53 (zeige TP53 Proteine) tumor suppression and bone marrow failure
Bre (zeige BRE Proteine) enhances osteoblastic differentiation by promoting the Mdm2-mediated degradation of p53 (zeige TP53 Proteine).
genetic and biochemical data support a role for Mdm2 in cardiac growth control through the regulation of p53 (zeige TP53 Proteine), the Pgc-1 family of transcriptional coactivators and the pivotal antioxidant Pink1 (zeige PINK1 Proteine)
The availability of large-scale genomic profiling datasets, like those from The Cancer Genome Atlas Research Network, have provided the opportunity to evaluate the consequences of MDM2 amplification and SNP inheritance across high-quality tumor samples from diverse cancer indications. [review]
findings document contrasting effects of ATM (zeige ATM Proteine)-Mdm2 signaling on p53 (zeige TP53 Proteine) tumor suppression and reveal that destabilizing Mdm2 by promoting its phosphorylation by ATM (zeige ATM Proteine) would be effective in treating oncogene (zeige RAB1A Proteine)-induced malignancies.
the existence of an unusual functional interplay between STATs and CREB (zeige CREB1 Proteine) at the onset of adipogenesis through shared CRTC cofactors, is reported.
Mdm2 expression is required for cell survival even in the absence of p53 (zeige TP53 Proteine). Moreover, results suggest that p73 (zeige ARHGAP24 Proteine) compensates for loss of p53 (zeige TP53 Proteine).
In Fmr1 (zeige FMR1 Proteine) KO neurons, Mdm2 is hyperphosphorylated, nuclear localized basally, and unaffected by MEF2 (zeige MEF2C Proteine) activation, which our data suggest due to an enhanced interaction with Eukaryotic Elongation Factor (zeige TSFM Proteine) 1alpha (EF1alpha), whose protein levels are elevated in Fmr1 (zeige FMR1 Proteine) KO. Expression of a dephosphomimetic of Mdm2 rescues PSD-95 (zeige DLG4 Proteine) ubiquitination, degradation and synapse elimination in Fmr1 (zeige FMR1 Proteine) KO neurons.
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.
E3 ubiquitin-protein ligase Mdm2
, Mdm2, p53 E3 ubiquitin protein ligase homolog
, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein
, double minute 2, human homolog of; p53-binding protein
, oncoprotein Mdm2
, Mdm2 p53 binding protein homolog
, double minute 2 protein
, p53-binding protein Mdm2
, MDM2 alpha
, double minute 2 homolog
, double minute 2
, MDM2-like protein
, transformed mouse 3T3 cell double minute 2
, murine double minute 2 homolog