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anti-Human ATM Antikörper:
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Human Monoclonal ATM Primary Antibody für ChIP, ELISA - ABIN151775
Naka, Tachibana, Ikeda, Motoyama: Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts. in The Journal of biological chemistry 2004
Show all 116 Pubmed References
Human Polyclonal ATM Primary Antibody für ICC, FACS - ABIN151030
Out, Hoekstra, de Jager, de Vos, van der Westhuyzen, Webb, Van Eck, Biessen, Van Berkel: Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice. in Journal of lipid research 2005
Show all 78 Pubmed References
Human Monoclonal ATM Primary Antibody für ICC, IF - ABIN151622
Lai, Chun, Nahas, Mitui, Gamo, Du, Gatti: Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons. in Proceedings of the National Academy of Sciences of the United States of America 2004
Show all 26 Pubmed References
Human Monoclonal ATM Primary Antibody für ICC, IF - ABIN151772
Yalcin, Zhang, Luciano, Mungamuri, Marinkovic, Vercherat, Sarkar, Grisotto, Taneja, Ghaffari: Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. in The Journal of biological chemistry 2008
Show all 21 Pubmed References
Human Polyclonal ATM Primary Antibody für IHC - ABIN362100
Kang, Guo, Tan, Zhao, Tang, Lu: Expression status of ataxia-telangiectasia-mutated gene correlated with prognosis in advanced gastric cancer. in Mutation research 2008
Show all 8 Pubmed References
Human Polyclonal ATM Primary Antibody für IP, PLA - ABIN151739
Kirshner, Jobling, Pajares, Ravani, Glick, Lavin, Koslov, Shiloh, Barcellos-Hoff: Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress. in Cancer research 2006
Show all 4 Pubmed References
Monoclonal ATM Primary Antibody für IF, WB - ABIN534124
Ye, Franco, Santos, Nelson, Kaufman, Adams: Defective S phase chromatin assembly causes DNA damage, activation of the S phase checkpoint, and S phase arrest. in Molecular cell 2003
Show all 3 Pubmed References
Human Monoclonal ATM Primary Antibody für ICC, IF - ABIN2668604
Shrivastav, Miller, De Haro, Durant, Chen, Chen, Nickoloff: DNA-PKcs and ATM co-regulate DNA double-strand break repair. in DNA repair 2009
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Human Monoclonal ATM Primary Antibody für ELISA, WB - ABIN965618
ORegan, Kiely, OGara: Expression of the adenyl cyclase-encoding gene (cya) of Rhizobium meliloti F34: existence of two cya genes? in Gene 1990
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Human Polyclonal ATM Primary Antibody für IF (p), IHC (p) - ABIN679103
Yin, Jiang, Peng, Cui, Zhou, He, Zuo, Ouyang, Fan, Fang: The molecular mechanism of G2M cell cycle arrest induced by AFB1 in the jejunum. in Oncotarget 2016
Show all 2 Pubmed References
our data indicate that ATR and ATM are both needed for intestinal stem cell maintenance and proliferation; ATR seems to play a bigger role than does ATM.
TCTP (zeige TPT1 Antikörper) has a role in regulating ATM activity to control genome stability and organ development in Drosophila melanogaster
A stringent requirement for the conserved function of Ataxia Telangiectasia Mutated (ATM) in telomere protection during early embryonic development, is identified.
ATM is primarily required for the meiotic DSB repair response, which includes functions in DNA damage repair and negative feedback control over the level of programmed DSBs during meiosis.
Molecular genetic characterization of Drosophila ATM conserved functional domains.
ATM checkpoint kinase (zeige ATR Antikörper) plays a role in telomere maintenance that is independent of telomerase regulation.
Drosophila ATM and Mre11 (zeige MRE11A Antikörper) are essential for the G2/M checkpoint induced by low-dose irradiation.
Results suggest that ATM and ATR protect telomere integrity by safeguarding chromatin architecture that favors the loading of telomere-elongating, capping, and silencing proteins.
Dna2 (zeige DNA2 Antikörper) co-localizes in foci with RPA (zeige RPA1 Antikörper) and is found in a complex with replication fork components And-1 and Mcm10 (zeige MCM10 Antikörper). Dna2 (zeige DNA2 Antikörper) interacts with the DSB repair and checkpoint proteins Nbs1 (zeige NLRP2 Antikörper) and ATM.
ATM and ATR (zeige ATR Antikörper) prevent accumulation of chromosomal abnormalities by promoting Mre11 (zeige MRE11A Antikörper)/Rad50 (zeige RAD50 Antikörper)/Nbs1 (zeige NLRP2 Antikörper) dependent recovery of collapsed replication forks.
ATM and ATR (zeige ATR Antikörper) phosphorylate the functionally critical replication protein Mcm2 (zeige MCM2 Antikörper) during both DNA damage and replication checkpoint responses in Xenopus egg extracts
PP2A counteracts ATM and ATR in a DNA damage checkpoint in Xenopus egg extracts
Data show that ATM (ataxia-telangiectasia mutated) regulates Xenopus TopBP1 (zeige TOPBP1 Antikörper) by phosphorylating serine 1131 and thereby strongly enhancing association of TopBP1 (zeige TOPBP1 Antikörper) with ATR (zeige ATR Antikörper)(ATM and Rad3-related).
ATM and ATR (zeige ATR Antikörper) control mitotic events in vertebrate cells by targeting CEP63 (zeige CEP63 Antikörper) and centrosome dependent spindle assembly.
These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM promotes the TopBP1 (zeige TOPBP1 Antikörper)-dependent activation of ATR (zeige ATR Antikörper)-ATRIP (zeige ATRIP Antikörper) in response to double-stranded DNA breaks.
The Fanconi anemia protein (zeige FANCF Antikörper) FANCM (zeige FANCM Antikörper) is controlled by FANCD2 (zeige FANCD2 Antikörper) and the ATR (zeige ATR Antikörper)/ATM pathways.
molecular cloning of the coding sequence of the catalytic domain of the zebrafish homologue of ATM
Characterization of ataxia telangiectasia protein.
High ATM expression is associated with chemotherapeutic resistance in gastric cancer.
No significant association of ATM rs11212592 with lung cancer was found in five genetic models in Chinese population. Haplotypes consisting of PPP1R13L (zeige PPP1R13L Antikörper) rs1970764 and ATM rs11212592 may be associated with lung cancer.
The miR (zeige MLXIP Antikörper)-449a/ATDC (zeige TRIM29 Antikörper) axis plays an important role in the development and progression of pancreatic cancer.
The ATM structure shows the detailed topology of the regulator-interacting N-terminal helical solenoid. The ATM conformational dynamics shown by the structures represent an important step in understanding the enzyme regulation.
ATM and CDK2 control the chromatin remodeling activity of CSB in the regulation of double strand break repair pathway choice.
Data suggest that ataxia telangiectasia mutated protein (ATM) mutational status in lung cancer is a mechanistic biomarker for MEK (zeige MAP2K1 Antikörper) inhibitor response.
Data suggest a close association between the nonfunctionality of ATM/p53 (zeige TP53 Antikörper) pathway and accumulation of p27Kip1 (zeige CDKN1B Antikörper) in chronic lymphocytic leukemia (CLL) cells in response to DNA damage.
Letter: BRCA2 (zeige BRCA2 Antikörper)- and ATM-mutated prostate cancer sensitive to high dose testosterone.
Radiation-activated ataxia-telangiectasia mutated kinase/p38 (zeige CRK Antikörper) signaling positively contributed to the nucleus to cytosol translocation of HuR (zeige ELAVL1 Antikörper).
No significant differences were presented in DNA methylation (zeige HELLS Antikörper) levels of RASSF1A (zeige RASSF1 Antikörper) and ATM between the sporadic breast cancer cases and the healthy controls.
Ataxia telangiectasia (AT) is a progressive multisystem disorder caused by mutations in the AT-mutated (ATM) gene. We engineered a novel porcine model of AT
ATM influenced the meiotic and cytoplasmic maturation of porcine oocytes.
ATM plays critical role in arsenite induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint signaling molecules.
radiation-induced eNOS (zeige NOS3 Antikörper) activation in bovine aortic endothelial cells is regulated by ATM and HSP90 (zeige HSP90 Antikörper)
SOD2 (zeige SOD2 Antikörper) expression is ATM- and RelA (zeige NFkBP65 Antikörper)-dependent, ATM knockdown renders cells sensitive to pro-oxidant exposure, and SOD mimetics partially rescue this sensitivity. Mice with germline deletion of Atm fail to develop mature mammary glands, but using a conditional knockout approach, we determined that Atm deletion significantly diminished the expression of Sod2 (zeige SOD2 Antikörper).
These data suggest that ATM and ATR are part of the cellular "infrastructure" that maintains the excitatory/inhibitory balance of the nervous system.
ATM has a role in homology-directed repair (HDR (zeige GATA3 Antikörper)) independent of the BRCA1 (zeige BRCA1 Antikörper)-53BP1 (zeige TP53BP1 Antikörper) antagonism; its HDR (zeige GATA3 Antikörper) function can become critical in certain contexts
intestinal tuft cells play an important role in regulating the ATM mediated DNA damage response, for epithelial cell survival/self-renewal via a Dclk1 (zeige DCLK1 Antikörper) dependent mechanism
in the Atm(-/-) MEFs, the same Radiofrequency electromagnetic fields exposure for 12 h induced both SSBs and double-strand breaks and activated the two repair processes, which also reduced the DNA damage to less than the control level after prolonged exposure. The observed phenomenon is similar to the hormesis of a toxic substance at a low dose
ATM haplodeficiency decreases fibroblast senescence and vascular endothelial growth factor (zeige VEGF Antikörper) production and impaired angiogenesis in response to myocardial infarction, leading to accelerated heart failure.
H2AX (zeige H2AFX Antikörper) shows a similar influence as ATM.
The ATM protein is a key mediator of H2O2 preconditioning.
ATM is the primary kinase responsible for phosphorylation of Hsp90alpha (zeige HSP90AA2 Antikörper) after exposure ionizing radiation.
These findings define an antagonistic function of ATM and MAPK7 (zeige MAPK7 Antikörper) in the thymocyte response to DNA damage, and suggest that the lack of MAPK7 (zeige MAPK7 Antikörper) inhibits thymic lymphoma growth in Atm-/- mice by partially restoring the DNA damage response in thymocytes.
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates\; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
, ataxia telangiectasia mutated
, ataxia telengiesctasia mutated
, ataxia-telangiectasia mutated
, drosophila ATM
, ataxia telangiectasia mutated (includes complementation groups A, C and D)
, ataxia telangiectasia mutated protein
, serine-protein kinase ATM-like
, ataxia telangiectasia mutated (atm)
, A-T mutated
, AT mutated
, TEL1, telomere maintenance 1, homolog
, serine-protein kinase ATM
, Ataxia telangiectasia gene mutated in human beings
, ataxia telangiectasia mutated homolog
, A-T mutated homolog
, ATM (ataxia telangiectasia mutated)
, ataxia telangiectasia gene mutated in human beings