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anti-Human ATM Antikörper:
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Human Monoclonal ATM Primary Antibody für ChIP, ELISA - ABIN151775
Naka, Tachibana, Ikeda, Motoyama: Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts. in The Journal of biological chemistry 2004
Show all 114 Pubmed References
Human Polyclonal ATM Primary Antibody für ICC, FACS - ABIN151030
Out, Hoekstra, de Jager, de Vos, van der Westhuyzen, Webb, Van Eck, Biessen, Van Berkel: Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice. in Journal of lipid research 2005
Show all 77 Pubmed References
Human Monoclonal ATM Primary Antibody für ICC, IF - ABIN151622
Lai, Chun, Nahas, Mitui, Gamo, Du, Gatti: Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons. in Proceedings of the National Academy of Sciences of the United States of America 2004
Show all 26 Pubmed References
Human Monoclonal ATM Primary Antibody für ICC, IF - ABIN151772
Yalcin, Zhang, Luciano, Mungamuri, Marinkovic, Vercherat, Sarkar, Grisotto, Taneja, Ghaffari: Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. in The Journal of biological chemistry 2008
Show all 20 Pubmed References
Human Polyclonal ATM Primary Antibody für IP, PLA - ABIN151739
Kirshner, Jobling, Pajares, Ravani, Glick, Lavin, Koslov, Shiloh, Barcellos-Hoff: Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress. in Cancer research 2006
Show all 4 Pubmed References
Human Polyclonal ATM Primary Antibody für IHC - ABIN362100
Kang, Guo, Tan, Zhao, Tang, Lu: Expression status of ataxia-telangiectasia-mutated gene correlated with prognosis in advanced gastric cancer. in Mutation research 2008
Show all 8 Pubmed References
Human Monoclonal ATM Primary Antibody für ELISA, WB - ABIN965618
ORegan, Kiely, OGara: Expression of the adenyl cyclase-encoding gene (cya) of Rhizobium meliloti F34: existence of two cya genes? in Gene 1990
Show all 4 Pubmed References
Human Monoclonal ATM Primary Antibody für ICC, IF - ABIN2668604
Shrivastav, Miller, De Haro, Durant, Chen, Chen, Nickoloff: DNA-PKcs and ATM co-regulate DNA double-strand break repair. in DNA repair 2009
Show all 3 Pubmed References
Human ATM Primary Antibody für IHC - ABIN965619
Gupta, Sharma, Young, Agarwal, Smith, Paull, Lucchesi, Khanna, Ludwig, Pandita: Involvement of human MOF in ATM function. in Molecular and cellular biology 2005
Show all 4 Pubmed References
Human Polyclonal ATM Primary Antibody für IF (p), IHC (p) - ABIN679103
Yin, Jiang, Peng, Cui, Zhou, He, Zuo, Ouyang, Fan, Fang: The molecular mechanism of G2M cell cycle arrest induced by AFB1 in the jejunum. in Oncotarget 2016
Show all 2 Pubmed References
our data indicate that ATR and ATM are both needed for intestinal stem cell maintenance and proliferation; ATR seems to play a bigger role than does ATM.
TCTP (zeige TPT1 Antikörper) has a role in regulating ATM activity to control genome stability and organ development in Drosophila melanogaster
A stringent requirement for the conserved function of Ataxia Telangiectasia Mutated (ATM) in telomere protection during early embryonic development, is identified.
ATM is primarily required for the meiotic DSB repair response, which includes functions in DNA damage repair and negative feedback control over the level of programmed DSBs during meiosis.
Molecular genetic characterization of Drosophila ATM conserved functional domains.
ATM checkpoint kinase (zeige ATR Antikörper) plays a role in telomere maintenance that is independent of telomerase regulation.
Drosophila ATM and Mre11 (zeige MRE11A Antikörper) are essential for the G2/M checkpoint induced by low-dose irradiation.
Results suggest that ATM and ATR protect telomere integrity by safeguarding chromatin architecture that favors the loading of telomere-elongating, capping, and silencing proteins.
Dna2 (zeige DNA2 Antikörper) co-localizes in foci with RPA (zeige RPA1 Antikörper) and is found in a complex with replication fork components And-1 and Mcm10 (zeige MCM10 Antikörper). Dna2 (zeige DNA2 Antikörper) interacts with the DSB repair and checkpoint proteins Nbs1 (zeige NLRP2 Antikörper) and ATM.
ATM and ATR (zeige ATR Antikörper) prevent accumulation of chromosomal abnormalities by promoting Mre11 (zeige MRE11A Antikörper)/Rad50 (zeige RAD50 Antikörper)/Nbs1 (zeige NLRP2 Antikörper) dependent recovery of collapsed replication forks.
ATM and ATR (zeige ATR Antikörper) phosphorylate the functionally critical replication protein Mcm2 (zeige MCM2 Antikörper) during both DNA damage and replication checkpoint responses in Xenopus egg extracts
PP2A counteracts ATM and ATR in a DNA damage checkpoint in Xenopus egg extracts
Data show that ATM (ataxia-telangiectasia mutated) regulates Xenopus TopBP1 (zeige TOPBP1 Antikörper) by phosphorylating serine 1131 and thereby strongly enhancing association of TopBP1 (zeige TOPBP1 Antikörper) with ATR (zeige ATR Antikörper)(ATM and Rad3-related).
ATM and ATR (zeige ATR Antikörper) control mitotic events in vertebrate cells by targeting CEP63 (zeige CEP63 Antikörper) and centrosome dependent spindle assembly.
These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM promotes the TopBP1 (zeige TOPBP1 Antikörper)-dependent activation of ATR (zeige ATR Antikörper)-ATRIP (zeige ATRIP Antikörper) in response to double-stranded DNA breaks.
The Fanconi anemia protein (zeige FANCF Antikörper) FANCM (zeige FANCM Antikörper) is controlled by FANCD2 (zeige FANCD2 Antikörper) and the ATR (zeige ATR Antikörper)/ATM pathways.
molecular cloning of the coding sequence of the catalytic domain of the zebrafish homologue of ATM
Characterization of ataxia telangiectasia protein.
study expands the spectrum of ATM pathogenic variants in Iran.
Our data showed that relative TP53 (zeige TP53 Antikörper) mRNA expression was not significantly altered in both tissues exposed to lasers. For ATM, relative mRNA expression in skin tissue was not significantly altered, but in muscle tissue, laser exposure increased relative ATM mRNA expression. Low-level red and infrared laser radiations alter ATM mRNA expression related to DNA stability in skeletal muscle tissue.
The ATM and Rad3-Related (ATR) Protein Kinase (zeige ATR Antikörper) Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication
ATM could be activated by lung cancer-associated TNF-alpha (zeige TNF Antikörper), up-regulate MMP-13 (zeige MMP13 Antikörper) expression and thereby augment tumor metastasis
these results indicate that ATM loss seems to be an early event in non-small cell lung cancer carcinogenesis and is an independent prognostic factor associated with worse survival in stage II/III patients.
Low ATM gene expression is associated with breast cancer.
Our results demonstrate that sorafenib combined with KU-55933 ( specific ATM inhibitor)treatment does effectively inhibit proliferation of HCC (zeige FAM126A Antikörper) cell lines synergistically. These data suggests that KU-55933 may be a promising chemosensitizer to sorafenib in the treatment of HCC (zeige FAM126A Antikörper)
Authors further showed that LRRK2 phosphorylation is abolished in the absence of ATM, suggesting that LRRK2 phosphorylation requires ATM.
somatic mutations in the ataxia-telangiectasia mutated gene may have an effect of the phenotype of non-small cell lung cancer
We found that phosphorylation of histone H2AX on Ser139 (gamma-H2AX (zeige H2AFX Antikörper)), a biomarker of DSBs, and phosphorylation of ATM at Ser1981, Chk2 (zeige CHEK2 Antikörper) at Thr68, and p53 (zeige TP53 Antikörper) at Ser15, part of signaling pathways associated with DSBs, are elevated in these cells.
Ataxia telangiectasia (AT) is a progressive multisystem disorder caused by mutations in the AT-mutated (ATM) gene. We engineered a novel porcine model of AT
ATM influenced the meiotic and cytoplasmic maturation of porcine oocytes.
ATM plays critical role in arsenite induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint signaling molecules.
radiation-induced eNOS (zeige NOS3 Antikörper) activation in bovine aortic endothelial cells is regulated by ATM and HSP90 (zeige HSP90 Antikörper)
H2AX (zeige H2AFX Antikörper) shows a similar influence as ATM.
The ATM protein is a key mediator of H2O2 preconditioning.
ATM is the primary kinase responsible for phosphorylation of Hsp90alpha (zeige HSP90AA2 Antikörper) after exposure ionizing radiation.
These findings define an antagonistic function of ATM and MAPK7 (zeige MAPK7 Antikörper) in the thymocyte response to DNA damage, and suggest that the lack of MAPK7 (zeige MAPK7 Antikörper) inhibits thymic lymphoma growth in Atm-/- mice by partially restoring the DNA damage response in thymocytes.
ATM/G6PD (zeige G6PD Antikörper)-driven redox metabolism promotes FLT3 (zeige FLT3 Antikörper) inhibitor resistance in acute myeloid leukemia (zeige BCL11A Antikörper) that can be successfully reversed.
Baf60b (zeige SMARCD2 Antikörper), a member of the SWI/SNF chromatin remodeling complex (zeige SMARCA2 Antikörper), links chromatin opening to ATM activation by facilitating ATM recruitment to the open chromatin regions of a panel of hepatic gene loci.
Results demonstrate that alterations in ATM levels are responsible for pronounced and anticipated GABAergic development and function. Since GABA transmission is strongly linked to the correct brain development and plasticity, this study lays basics for both a more clear comprehension of mechanisms associated with brain development.
These data indicate that defective Atm reduces the redox homeostasis of the testis and genetic integrity of sperm by regulating glutathione levels independently from G6PDH (zeige G6PD Antikörper) activity.
WSB1 (zeige WSB1 Antikörper) is one of the key players of early oncogenic events through ATM degradation and destruction of the tumorigenesis barrier.
Collectively, these data indicated that ATR (zeige ATR Antikörper) or ATM inhibition represent potential therapeutic strategies for the treatment of AML (zeige RUNX1 Antikörper), especially MLL (zeige MLL Antikörper)-driven leukemias.
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates\; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
, ataxia telangiectasia mutated
, ataxia telengiesctasia mutated
, ataxia-telangiectasia mutated
, drosophila ATM
, ataxia telangiectasia mutated (includes complementation groups A, C and D)
, ataxia telangiectasia mutated protein
, serine-protein kinase ATM-like
, ataxia telangiectasia mutated (atm)
, A-T mutated
, AT mutated
, TEL1, telomere maintenance 1, homolog
, serine-protein kinase ATM
, Ataxia telangiectasia gene mutated in human beings
, ataxia telangiectasia mutated homolog
, A-T mutated homolog
, ATM (ataxia telangiectasia mutated)
, ataxia telangiectasia gene mutated in human beings