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Data show that pregnane X receptor/retinoid X receptor PXR/RXR-[alpha], RXR-[beta], or RXR-[gamma] expression was noted in 9 (16.4%), 9 (16.4%), and 10 (18.2%) pancreatic adenocarcinoma cases, respectively.
RXR interaction is necessary for NPM-RAR-mediated myeloid maturation arrest.
A fatty acid-binding protein 7/RXRbeta pathway enhances survival and proliferation in triple-negative breast cancer.
The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer
polymorphism is unrelated to schizophrenia or alcoholism.
Family studies revealed significant linkage disequilibrium between the RXRB alleles and a number of HLA-DPB1 alleles.
Diminished RXRbeta expression might be related to prostate cancer progression. Because responsiveness to retinoic acid treatments depends on expression of different receptors, it is important to study their expression before therapy.
partial dissociation of TR/retinoid X receptor heterodimer complex from the TRE is involved in the suppression of transcription induced by polychlorinated biphenyls
The retinoid X receptor, beta is expressed widely and can be found in almost every tissue.
In the RXRB polymorphism, no genotype TT is observed in patients with psoriasis guttata with a positive personal history of repeated tonsillitis (p(corr) = 0.001).
In healthy elderly men reduction of RXRbeta expression in peripheral blood mononuclear cells might be a common feature of physiological senescence.
PPARgamma/retinoid X receptor complex released from activated platelets in microparticles was internalized by a monocytic cell line.
the RAR:RXR and LXR:RXR-mediated transcriptional program in embryonic stem cells, neural progenitors and terminally differentiated neurons, is reported.
RXRs modulate post-UVR survival of dermal fibroblasts in a "non-cell autonomous" manner, underscoring their role in immune surveillance, while independently mediating post-UVR melanocyte survival in a "cell autonomous" manner
RXRA and RXRB display specific roles in modulating T3-dependent regulation of thyrotropin releasing hormone.
During corpus callosum demyelination, retinoid X receptor beta expression is significantly increased.
The expression of dominant-negative RAR (dnRAR) in the forebrain down-regulated the expression of RARbeta, a target gene of RAR/RXR, indicating that dnRAR mice exhibit dysfunction of the RAR/RXR signaling pathway.
Using the light-induced retinal degeneration (LIRD) mouse model, which provides a unique platform for exploring the mechanisms underlying neuritogenesis, we found that retinoid X receptors (RXRs) control neuritogenesis.
Modulation of RXR-beta in beta-cells may be a new therapeutic approach for improving impaired insulin secretion in type 2 diabetes.
The ablation of all RXR (alpha, beta and gamma isotypes) in Sertoli cells does not recapitulate the phenotype generated upon ablation of all three retinoic acid receptors.
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
MHC class I promoter binding protein
, nuclear receptor subfamily 2 group B member 2
, retinoic acid receptor RXR-beta
, nuclear receptor co-regulator 1
, nuclear receptor coregulator 1
, retinoic acid receptor, beta
, xRXR beta
, retinoid X receptor, beta
, retinoid X receptor beta
, nuclear receptor subfamily 2 group B member 2-A
, retinoic acid receptor RXR-beta-A
, retinoid X receptor beta-A
, retinoid receptor-epsilon
, retinoid x receptor, epsilon
, MHC class I regulatory element-binding protein H-2RIIBP
, nuclear receptor subfamily 2 group B member 2-B
, retinoic acid receptor RXR-beta-B
, retinoic acid receptor RXR-delta
, retinoid X receptor beta-B
, retinoid X receptor delta
, retinoid receptor-delta
, retinoid x receptor, delta