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ASK1 phosphorylated and stabilized TLX, which led induction of HIF-1alpha, and its downstream VEGF-A in an Akt dependent manner.
The interaction between TLX and TGF-beta may play an important role in the regulation of proliferation and tumor-initiating properties of glioblastoma cells.
TLX and miR-219 have an important role in both normal neurodevelopment and in schizophrenia patient iPSC-derived NSCs. TLX has a role in regulating microRNA processing, independent of its well-characterized role in transcriptional regulation.
TLX downregulation induces TET3 expression and inhibits glioblastoma tumorigenesis and self-renewal in glioblastoma stem cells.
TLX has a role in regulating growth and invasion in ERalpha-negative breast cancer cells
TLX biological role in mental illness and gliomagenesis
Increased NR2E1 level may be closely associated with inflammation and disorder of lipid and glucose metabolism in diabetic patients.
These results suggest that let-7b, by forming a negative feedback loop with TLX, provides a novel model to regulate the proliferation and differentiation of retinal progenitors in vitro
NR2E1 regulates CBX7 and restrains senescence in neural stem cells.
TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21(WAF1) (/) (CIP1) ) and SIRT1 genes
The effect of TLX on the proliferative, invasive and migratory properties of IMR-32 cells attributed to the recruitment of TLX to both MMP-2 and Oct-4 gene promoters, which resulted in the respective gene activation.
TLX is involved in interleukin (IL)-1beta-induced changes in adult hippocampal neurogenesis.
TLX/NR2E1 and related NRs such as PNR and COUPTFs can selectively associate with the developmental corepressor BCL11A via a conserved motif F/YSXXLXXL/Y within the RID1 and RID2 domains. The interaction with BCL11A facilitates TLX-mediated repression of the RARb2 gene.
No mutations in the NR2E1 gene were found in aniridia patients.
Enriched expression of TLX in higher-grade human gliomas is observed.
BCL11A is a novel TLX coregulator that might be involved in TLX-dependent gene regulation in the brain.
Cerebrum and olfactory bulb hypoplasia, hallmarks of the Nr2e1-null mice phenotype, were not fully corrected in animals harboring one functional copy of human NR2E1.
Transgenic TLX acts as an essential regulator that ensures the proliferative ability of postnatal neural stem cells by controlling their activation through genetic interaction with p53 and other signaling pathways.
Nuclear orphan receptor TLX induces Oct-3/4 for the survival and maintenance of adult hippocampal progenitors upon hypoxia.
Results demonstrate that social isolation stress during adolescence attenuates an exercise-induced increase in neurogenesis. This effect is most pronounced in the ventral hippocampus. TLX is necessary for the pro-neurogenic effects of exercise during adolescence.
This study demonstrated that deletion of Tlx impairs motor, cognitive and anxiety-related behaviours during adolescence and adulthood in male and female mice with most effects occurring during adolescence rather than adulthood, independent of housing conditions.
This study demonstrated that Nr2e1 could be regulated by retinoic acid, which would aid a better understanding of the mechanism underlying RA-induced brain abnormality.
Nr2e1 deficiency augments palmitate-induced oxidative stress. Nr2e1 deficiency also resulted in decreases in antioxidant enzymes and expression level of Nrf2.
TLX is essential for SOX2-mediated in vivo reprogramming of astrocytes and itself is also sufficient to induce neurogenesis in the adult striatum.
TLX, an essential regulator of NSC proliferation and self-renewal, inhibits miR-219 processing. miR-219 suppresses mouse NSC proliferation downstream of TLX.
At high glucose concentrations in vitro, AdipoR1 regulated the survival of neural stem cells through the p53/p21 pathway and the proliferation- and differentiation-related factors of neural stem cells via TLX.
role in regulating STAT1 signaling and host defense
Nr2e1 regulates processes involved in neurite development and terminal retinal cell differentiation.
we have provided new candidate interacting partners and numerous well-developed testable hypotheses for understanding the pathways by which Nr2e1 functions to regulate neocortex development.
TLX overexpression promotes beta cell proliferation and decreases cell apoptosis causes significant expression changes of 225 genes.
data suggest that miR-378 is a novel miRNA that regulates NSC proliferation and differentiation via targeting TLX
MiR-9 and TLX form a feedback regulatory loop to coordinate the proliferation.
These results suggest a strong association between hippocampal neurogenesis and cognition, as well as significant contributions of TLX to hippocampal neurogenesis, learning, and memory.
Results of the current study suggest aggression displayed by TLX null and heterozygous mice involves 5-HT(2A/C) receptors.
By interacting with its cofactors, Tlx represses its target genes and plays an important role in the maintenance of adult neural stem cells. (Review)
Interaction of NSD1 with the NR2E/F subfamily including COUP-TFI, COUP-TFII, EAR2 and TLX requires an F/YSXXLXXL/Y motif. Interactions of NSD1 with liganded NRs require an overlapping LXXLL motif.
The developmental expression profile of zebrafish nr2e1 and nr2e3 is consistent with evolutionary conserved functions in eye and rostral brain structures.
Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). Involved in the regulation of early eye development.
nuclear receptor subfamily 2 group E member 1
, nuclear receptor subfamily 2, group E, member 1
, nuclear receptor TLX
, protein tailless homolog
, tailes-related receptor
, tailless homolog
, Drosophila terminal/gap gene tailless homolog