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anti-Human NR1D1 Antikörper:
anti-Mouse (Murine) NR1D1 Antikörper:
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Human Monoclonal NR1D1 Primary Antibody für ELISA, IF - ABIN396391
Ma, Zhong, Jiang, Fontaine, Li, Fu, Olkkonen, Staels, Yan: Increased atherosclerotic lesions in LDL receptor deficient mice with hematopoietic nuclear receptor Rev-erb? knock- down. in Journal of the American Heart Association 2013
Human Monoclonal NR1D1 Primary Antibody für IF, IHC (p) - ABIN564127
Nakabayashi, Ohta, Yamamoto, Susuki, Taguchi, Tanabe, Kondo, Hatanaka, Nagao, Tanizawa: Clock-controlled output gene Dbp is a regulator of Arnt/Hif-1? gene expression in pancreatic islet ?-cells. in Biochemical and biophysical research communications 2013
Nr1d1/Rev-erbalpha has a direct role in circadian clock regulation of autophagy, which also involves Cebpb/(C/ebpbeta) indirectly in zebrafish
Two differentially active alternative promoters control the expression of the zebrafish orphan nuclear receptor gene Rev-erbalpha.
Data suggest that MYC induction of REV-ERBalpha is both persistent and recurrent across many inducible MYC model systems.
NR1D1 interacted with poly(ADP-ribose) polymerase 1 (PARP1) and subsequently inhibited catalytic activity of PARP1.
NR1D1 and BMAL1 mRNA and protein levels were significantly reduced in OA compared to normal cartilage. In cultured human chondrocytes, a clear circadian rhythmicity was observed for NR1D1 and BMAL1.
To determine the impact of REV-ERBalpha activation in the cigarette smoke (CS)-induced lung inflammatory response, we treated primary small airway epithelial cells with CS extract or lipopolysaccharide in the absence or presence of pre-treatment with the REV-ERBalpha agonist GSK 4112.
Downregulation of NR1D1 in MCF7 cells resulted in resistance to doxorubicin, both in vitro and in vivo Analysis of four public patient data sets indicated that NR1D1 expression correlates positively with clinical outcome in breast cancer patients who received chemotherapy. Our findings suggest that NR1D1 and its ligands provide therapeutic options that could enhance the outcomes of chemotherapy in breast cancer patients
Highly quantitative fluorescence anisotropy assays in competition mode revealed that the rev-erbA-alpha specificity for the NCoR corepressor lies in the first two residues of the beta-strand in Interaction Domain 1 of NCoR.
Data show that ubiquitin E3 ligase Siah2 depletion delays circadian degradation of nuclear hormone receptor RevErbalpha (Nr1d1) and lengthens period length.
the role of NR1D1 polymorphisms in the regulation of Nuclear receptor REV-ERBalpha and circadian rhythms regulation
associations between NR1D1, RORA and RORB genes and bipolar disorder.(
CRY2 and REV-ERB ALPHA as the clock genes upregulated in obesity during the 24 h period and that REV-ERB ALPHA is an important gene associated with MS.
Our results suggest that the REV-ERB ALPHA rs939347 polymorphism could modulate body fat mass in men. The present work supports the role of REV-ERB ALPHA in the development of obesity as well as a potential target for the treatment of obesity
Using free-energy simulations, the study shows that rev-erbA-alpha-induced DNA deformation preferentially occurs by induced fit rather than by conformational selection, even though the DNA is only slightly distorted in the complex.
Rev-erbalpha is a novel regulator of hepatic stellate cell transdifferentation
apoA-IV inhibits hepatic gluconeogenesis by decreasing Glc-6-Pase and PEPCK gene expression through NR1D1.
Rev-erbalpha bestows protection against mycobacterial infection by direct gene repression of IL10 and thus provide a novel target in modulating macrophage microbicidal properties.
DBC1 modulates the stability and function of the nuclear receptor Rev-erb-alpha.
A haplotype block in REV-ERBalpha was associated with white matter lesion volumes in the Rotterdam Study I.
Genetic variants of NR1D1 associate with bipolar disorder.
Thyroid hormone receptor-alpha/NR1D1 polymorphisms were not associated with baseline characteristics, including serum TSH and free thyroxine. None of the polymorphisms were associated with bone mineral density or osteoporotic fractures.
in situ hybridization revealed that RORA and NR1D1 were expressed in human endometrial stromal and epithelial cells
results indicate that nuclear receptor subfamily 1 group D member 1(REV-ERBalpha) plays an inhibitory role in the expression of prostaglandin G/H synthetase(PTGS2) in both bovine uterine stromal and epithelial cells treated with ovarian steroids
Rev-ErbAalpha is highly expressed in articular chondrocytes
This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes.
nuclear receptor subfamily 1, group D, member 1
, nuclear receptor subfamily 1 group D member 1
, V-erbA-related protein 1
, nuclear receptor Rev-ErbA-alpha
, Rev-ErbA-alpha protein
, nuclear receptor protein
, orphan nuclear receptor
, rev-erb alpha
, rev-erbA alpha
, V-erbA-related protein EAR-1