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anti-Human NR1D1 Antikörper:
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Human Monoclonal NR1D1 Primary Antibody für IF, IHC (p) - ABIN564127
Nakabayashi, Ohta, Yamamoto, Susuki, Taguchi, Tanabe, Kondo, Hatanaka, Nagao, Tanizawa: Clock-controlled output gene Dbp is a regulator of Arnt/Hif-1? gene expression in pancreatic islet ?-cells. in Biochemical and biophysical research communications 2013
Nr1d1/Rev-erbalpha has a direct role in circadian clock regulation of autophagy, which also involves Cebpb/(C/ebpbeta) indirectly in zebrafish
Two differentially active alternative promoters control the expression of the zebrafish orphan nuclear receptor gene Rev-erbalpha.
REV-ERBalpha regulates cytoplasmic and nuclear O-GlcNAc transferase-controlled processes that integrate at the hepatic SREBF1 locus to control basal and insulin-induced expression of the temporally and nutritionally regulated lipogenic SREBP-1c transcript.
Data suggest that MYC induction of REV-ERBalpha is both persistent and recurrent across many inducible MYC model systems.
NR1D1 interacted with poly(ADP-ribose) polymerase 1 (PARP1) and subsequently inhibited catalytic activity of PARP1.
NR1D1 and BMAL1 mRNA and protein levels were significantly reduced in OA compared to normal cartilage. In cultured human chondrocytes, a clear circadian rhythmicity was observed for NR1D1 and BMAL1.
To determine the impact of REV-ERBalpha activation in the cigarette smoke (CS)-induced lung inflammatory response, we treated primary small airway epithelial cells with CS extract or lipopolysaccharide in the absence or presence of pre-treatment with the REV-ERBalpha agonist GSK 4112.
Downregulation of NR1D1 in MCF7 cells resulted in resistance to doxorubicin, both in vitro and in vivo Analysis of four public patient data sets indicated that NR1D1 expression correlates positively with clinical outcome in breast cancer patients who received chemotherapy. Our findings suggest that NR1D1 and its ligands provide therapeutic options that could enhance the outcomes of chemotherapy in breast cancer patients
Highly quantitative fluorescence anisotropy assays in competition mode revealed that the rev-erbA-alpha specificity for the NCoR corepressor lies in the first two residues of the beta-strand in Interaction Domain 1 of NCoR.
Data show that ubiquitin E3 ligase Siah2 depletion delays circadian degradation of nuclear hormone receptor RevErbalpha (Nr1d1) and lengthens period length.
the role of NR1D1 polymorphisms in the regulation of Nuclear receptor REV-ERBalpha and circadian rhythms regulation
associations between NR1D1, RORA and RORB genes and bipolar disorder.(
CRY2 and REV-ERB ALPHA as the clock genes upregulated in obesity during the 24 h period and that REV-ERB ALPHA is an important gene associated with MS.
Our results suggest that the REV-ERB ALPHA rs939347 polymorphism could modulate body fat mass in men. The present work supports the role of REV-ERB ALPHA in the development of obesity as well as a potential target for the treatment of obesity
Using free-energy simulations, the study shows that rev-erbA-alpha-induced DNA deformation preferentially occurs by induced fit rather than by conformational selection, even though the DNA is only slightly distorted in the complex.
Rev-erbalpha is a novel regulator of hepatic stellate cell transdifferentation
apoA-IV inhibits hepatic gluconeogenesis by decreasing Glc-6-Pase and PEPCK gene expression through NR1D1.
Rev-erbalpha bestows protection against mycobacterial infection by direct gene repression of IL10 and thus provide a novel target in modulating macrophage microbicidal properties.
DBC1 modulates the stability and function of the nuclear receptor Rev-erb-alpha.
A haplotype block in REV-ERBalpha was associated with white matter lesion volumes in the Rotterdam Study I.
Genetic variants of NR1D1 associate with bipolar disorder.
Thyroid hormone receptor-alpha/NR1D1 polymorphisms were not associated with baseline characteristics, including serum TSH and free thyroxine. None of the polymorphisms were associated with bone mineral density or osteoporotic fractures.
dynamic changes in stability of REV-ERBalpha protein couple the core clock to innate immunity.
results reveal a mechanism by which the circadian clock acts through REVERBa in liver on elements bound by HNF4A/HNF6 to direct GR action on energy metabolism.
results proved that the REV-ERB agonism inhibited osteoclastogenesis partially via FABP4 up-regulation.
Rev-erbalpha regulates experimental colitis through its repressive action on the NF-kappaB/Nlrp3 axis. Targeting Rev-erbalpha may represent a promising approach for prevention and management of colitis.
Taken together, Nr1d1 was found to play a pivotal role in corticogenesis via regulation of excitatory neuron migration and synaptic network formation. These results suggest that functional defects in NR1D1 may be related to autism spectrum disorder etiology and pathophysiology.
REV-ERBbeta is a known circadian regulatory protein that appears to be involved in neurogenesis via regulation of networks for cell proliferation and neural differentiation/maturation in adult neural stem cells.
Results show that both global and brain-specific deletions of Rev-erbalpha profoundly altered the expression of food-anticipatory components. This study gives evidence that Rev-erbalpha in the central nervous system is essential to shape the 24-hour pattern of activity in conditions of limited food access.
implicate Rev-Erbalpha in the modulation of the circadian responses to chronic methamphetamine
NR1D1 regulates the timing of NLRP3 expression and production of inflammatory cytokines by macrophages to reduce the severity of fulminant hepatitis.
Rev-erbalpha, a core repressive transcription factor of the clock, opposes functional loop formation between Rev-erbalpha-regulated enhancers and circadian target gene promoters by recruitment of the NCoR-HDAC3 co-repressor complex, histone deacetylation, and eviction of the elongation factor BRD4 and the looping factor MED1.
Data provide evidence for a possible repressive role of Rev-Erbalpha in the regulation of ORX signalling, highlighting an implication of the circadian clockwork in modulating food-reward behaviours with an important impact for the central regulation of overeating.
Data demonstrated that the circadian rhythm of testosterone synthesis in TM3 cells was disturbed following Fen treatment as evidenced by changes in the circadian rhythmicity of core clock genes (Bmal1, Rev-erbalpha, Roralpha).
REV-ERBalpha KO mice show a greater inflammatory response to 10 and 30 days of cigarette smoke, including increased neutrophil lung influx, pro-inflammatory cytokine release, and pro-senescence marker when compared to WT mice.
that REV-ERBalpha plays a major role in retinal information processing
A significant proportion of circadian lncRNAs are expressed at enhancer regions, mostly bound by two key circadian transcription factors, BMAL1 and REV-ERBalpha.
SHP and REV-ERBalpha play a critical role in controlling rhythmic CHOP expression in alcoholic fatty liver.
REV-ERBalpha binds to the C-terminal portion and GR to the N-terminal portion of HSP90alpha and HSP90beta, a chaperone responsible for the activation of proteins to ensure survival of a cell.
Our findings may throw light on the function of ApoA4 in inflammatory responses and acute-phase reactions, as well as the development of SERPINA3 relative diseases.
Using circular chromosome conformation capture sequencing, we systematically examined the interacting loci of a Bmal1-bound super-enhancer upstream of a clock gene Nr1d1 in mouse liver. Global analysis showed that cohesin-CTCF co-binding sites tend to insulate the phases of circadian oscillating genes while cohesin-non-CTCF sites are associated with high circadian rhythmicity of transcription.
Selective activation of RevErb-alpha during mitosis, allows a fit to experimental data on both period and phase of circadian clock.
results indicate that nuclear receptor subfamily 1 group D member 1(REV-ERBalpha) plays an inhibitory role in the expression of prostaglandin G/H synthetase(PTGS2) in both bovine uterine stromal and epithelial cells treated with ovarian steroids
Rev-ErbAalpha is highly expressed in articular chondrocytes
This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes.
nuclear receptor subfamily 1, group D, member 1
, nuclear receptor subfamily 1 group D member 1
, V-erbA-related protein 1
, nuclear receptor Rev-ErbA-alpha
, Rev-ErbA-alpha protein
, nuclear receptor protein
, orphan nuclear receptor
, rev-erb alpha
, rev-erbA alpha
, V-erbA-related protein EAR-1