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Mouse (Murine) NOTCH2 Protein expressed in CHO Cells - ABIN1344244
Fiorini, Merck, Wilson, Ferrero, Jiang, Koch, Auderset, Laurenti, Tacchini-Cottier, Pierres, Radtke, Luther, Macdonald: Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies. in Journal of immunology (Baltimore, Md. : 1950) 2009
ATRX (zeige ATRX Proteine), NOTCH1 (zeige NOTCH1 Proteine) and NOTCH2 expression varies in angiosarcomas and shows significant correlations with site of origin and poor clinical outcome
BANCR may promote melanoma cell growth through inhibition of miR204, leading to the activation of Notch2 pathway. Authors further demonstrated that BANCR knockdown inhibited tumor growth in vivo. Results suggest the BANCR/miR204/Notch2 axis mediates melanoma cell proliferation and tumor progression.
Altered expression of WFS1 (zeige WFS1 Proteine) and NOTCH2 genes may play a role in pathogenesis and development of DN in patients with T2DM.
IRF4 (zeige IRF4 Proteine) is overexpressed in human non-small cell lung cancer and activates the Notch (zeige NOTCH1 Proteine) signaling pathway.
Notch2 is important in Club cell differentiation in normal lungs and adenocarcinoma. Notch2 is regulated mutually with Notch1 (zeige NOTCH1 Proteine), and the balance of the expression of Notch (zeige NOTCH1 Proteine) receptors could determine the biological behaviours of lung cancer cells.
Notch2 is up-regulated in oesophageal squamous cell carcinoma tissues and could serve as a promising biomarker for identifying individuals with poor prognostic potential.
analysis of highly recurrent genetic lesions in components of the NF-kappaB pathway, of NOTCH1 and NOTCH2 as well as KMT2D that may have a role in ocular adnexal MALT-type marginal zone lymphomas
The SNHG12/miR (zeige MLXIP Proteine)-195-5p/Notch2-Notch (zeige NOTCH1 Proteine) signaling pathway axis might become a novel therapeutic target for osteosarcoma. SNHG12 functioned as a competing endogenous RNA, modulating the expression of Notch2 by sponging miR (zeige MLXIP Proteine)-195-5p in osteosarcoma.
NOTCH2 acts as an oncogene (zeige RAB1A Proteine) that promotes bladder cancer growth and metastasis through epithelial-to-mesenchymal transition, cell-cycle progression, and maintenance of stemness. Inhibition of NOTCH2 is a rational novel treatment strategy for invasive bladder cancer.
These data demonstrated fascin (zeige FSCN1 Proteine) as a critical regulator of breast cancer stem cell pool at least partially via activation of the Notch (zeige NOTCH1 Proteine) self-renewal signaling pathway.
The results suggest that CD19 (zeige CD19 Proteine) controls the differentiation of marginal zone precursors to marginal zone B cells by regulating ADAM28 (zeige ADAM28 Proteine)-mediated Notch2 cleavage.
Data (including data from studies in transgenic mice) suggest that signaling via Notch2 and Notch3 (zeige NOTCH3 Proteine) plays role in promoting cell differentiation and steroidogenesis in preovulatory granulosa cells; mechanism involves regulation of gene expression of Jag1 (zeige JAG1 Proteine) and Rbpj (zeige RBPJ Proteine). (Notch2 = Notch2 receptor; Notch3 (zeige NOTCH3 Proteine) = Notch3 (zeige NOTCH3 Proteine) receptor; Jag1 (zeige JAG1 Proteine) = jagged-1 (zeige JAG1 Proteine) protein; Rbpj (zeige RBPJ Proteine) = recombining binding protein suppressor of hairless (zeige RBPJ Proteine))
Notch2 physiologically regulates bone remodeling by inhibiting trabecular bone formation in the appendicular skeleton.
Notch2 was crucial in maintaining the integrity of the epithelial and smooth muscle layers of the distal conducting airways, and our data suggest that epithelial Notch (zeige NOTCH1 Proteine) signaling regulates multiple aspects of postnatal development in the distal lung and may represent a potential target for intervention in pulmonary diseases.
Authors confirmed that NOTCH2 is significantly over-expressed in EEA. In the most relevant endometrial adenocarcinoma cell model, Ishikawa H, altering miR (zeige MLXIP Proteine)-181c expression produces significant changes in NOTCH2 expression, consistent with direct targeting.
These findings highlight the molecular basis of Hajdu-Cheney syndrome (HCS (zeige HLCS Proteine)) pathogenesis and provide clinical insights into potential targeted therapeutic strategies for skeletal disorders associated with the aberrant FBW7 (zeige FBXW7 Proteine)/NOTCH2 pathway as observed in patients with HCS (zeige HLCS Proteine).
Hajdu-Cheney Syndrome is a devastating disease associated with a gain-of-NOTCH2 function resulting in diverse clinical manifestations
Lnc-LFAR1 binds directly to Smad2 (zeige SMAD2 Proteine)/3 and promotes transcription of TGFbeta (zeige TGFB1 Proteine), Smad2 (zeige SMAD2 Proteine), Smad3 (zeige SMAD3 Proteine), Notch2 and Notch3 (zeige NOTCH3 Proteine) which, in turn, results in TGFbeta (zeige TGFB1 Proteine) and Notch (zeige NOTCH1 Proteine) pathway activation.
Study indicates that knockdown of Notch2 promotes in vivo growth of triple-negative breast cancer (TNBC) and proposes that Notch2 functions as a tumor growth suppressor in TNBC.
Human biliary atresia and 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC (zeige DDC Proteine))-induced experimental cholestasis in mice are associated with increased expression of Notch2.
bovine herpesvirus 1 ORF2 protein reduced the trans-activation potential of Notch1 (zeige NOTCH1 Proteine) and Notch3 (zeige NOTCH3 Proteine), suggesting that ORF2 interfered with the trans-activation potential of Notch (zeige NOTCH1 Proteine).
DeltaC/Notch1a and Notch2 signaling is responsible for a survival signal provided by xanthophores to melanophores.
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.
, neurogenic locus notch homolog protein 2-like
, Notch homolog 2
, neurogenic locus notch homolog protein 2
, Motch B
, Notch gene homolog 2
, notch gene homolog 2
, notch receptor protein 6