NOTCH2 Produkte
(Notch 2 (NOTCH2))
Kategorien
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011].
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Ausgewählte NOTCH2 Kategorien
NOTCH2 Antikörper
High quality antibodies with extensive validation data.
NOTCH2 ELISA Kits
Reliable ELISA kits for a wide range of species.
NOTCH2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene NOTCH2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA
Validierungen
- (3)
- (1)
- (1)
Kat. Nr.
ABIN104899
Menge
200 μL
Datenblatt
Datenblatt
Reaktivität
Human, Monkey
Applikation
ELISA, IHC, IHC (p)
Validierungen
- (4)
Kat. Nr.
ABIN462087
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ELISA, IHC
Validierungen
- (3)
Kat. Nr.
ABIN3181821
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene NOTCH2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6968970
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6968969
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6958224
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene NOTCH2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (2)
Kat. Nr.
ABIN7275365
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7013569
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
CHO Cells
Validierungen
- (1)
Kat. Nr.
ABIN1344244
Menge
50 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren NOTCH2 Produkten
: "Potassium depletion induces cellular conversion in the outer medullary collecting duct altering Notch signaling pathway." in: Scientific reports, Vol. 10, Issue 1, pp. 5708, (2020) (PubMed).: "Protein Expression Analysis in Uterine Cervical Cancer for Potential Targets in Treatment." in: Pathology oncology research : POR, (2018) (PubMed).
: "Epistatic Association of CD14 and NOTCH2 Genetic Polymorphisms with Biliary Atresia in a Southern Chinese Population." in: Molecular therapy. Nucleic acids, Vol. 13, pp. 590-595, (2018) (PubMed).
: "NOTCH2 signaling confers immature morphology and aggressiveness in human hepatocellular carcinoma cells." in: Oncology reports, Vol. 34, Issue 4, pp. 1650-8, (2015) (PubMed).
: "RNA granule assembly and disassembly modulated by nuclear factor associated with double-stranded RNA 2 and nuclear factor 45." in: The Journal of biological chemistry, Vol. 289, Issue 30, pp. 21163-80, (2015) (PubMed).
: "Fatty acid binding protein 4 deficiency protects against oxygen-induced retinopathy in mice." in: PLoS ONE, Vol. 9, Issue 5, pp. e96253, (2015) (PubMed).
: "Interference of Notch 2 inhibits the progression of gliomas and induces cell apoptosis by induction of the cell cycle at the G0/G1 phase." in: Molecular medicine reports, Vol. 11, Issue 1, pp. 734-8, (2014) (PubMed).
: "Short hairpin RNA targeting Notch2 inhibits U87 human glioma cell proliferation by inducing cell cycle arrest and apoptosis in vitro and in vivo." in: Molecular medicine reports, Vol. 10, Issue 6, pp. 2843-50, (2014) (PubMed).
: "Macrophage-derived delta-like protein 1 enhances interleukin-6 and matrix metalloproteinase 3 production by fibroblast-like synoviocytes in mice with collagen-induced arthritis." in: Arthritis & rheumatology (Hoboken, N.J.), Vol. 66, Issue 10, pp. 2751-61, (2014) (PubMed).
: "Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and G?q-mediated Rho and ?v?6 integrin-dependent activation of TGF-?." in: The American journal of pathology, Vol. 181, Issue 4, pp. 1236-49, (2012) (PubMed).
Synonyme und alternative Namen zu NOTCH2
neurogenic locus notch homolog protein 2 (LOC581186), notch 2 (NOTCH2), notch 3 (notch3), notch 2 (Notch2), notch 2 (notch2), AGS2, AI853703, HJCYS, hN2, N2, notch6, sb:cb884Bezeichner auf Proteinebene für NOTCH2
- notch 2
- neurogenic locus notch homolog protein 2-like
- Notch homolog 2
- neurogenic locus notch homolog protein 2
- Motch B
- Notch gene homolog 2
- notch gene homolog 2
- notch receptor protein 6
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