anti-SIRT4 (SIRT4) Antikörper

Human Sirtuin 4 (SIRT4) Interaktionspartner

1. structural model of a complex of human Sirt4 and GDH (zeige GLUD1 Antikörper) in order to elucidate the molecular mechanism underlying the ADP-ribosylation of GDH (zeige GLUD1 Antikörper) by Sirt4

2. we propose that the SIRT4-OPA1 (zeige OPA1 Antikörper) axis is causally linked to mitochondrial dysfunction and altered mitochondrial dynamics that translates into aging-associated decreased mitophagy based on an unbalanced mitochondrial fusion/fission cycle.

3. SIRT4 protein levels in endometrioid adenocarcinoma were markedly lower than its non-neoplastic tissue counterpart (P< 0.001).

4. The function of the three mitochondrial sirtuins (SIRT3 (zeige SIRT3 Antikörper), SIRT4, SIRT5 (zeige SIRT5 Antikörper)) and their role in disease are reviewed.

5. Protein levels of SIRT 4 were significantly higher in HUVECs from HELLP pregnancies compared to control after 60 and 120 minutes of hypoxia.

6. we found that knock-out of mitochondrial sirtuin (zeige SIRT1 Antikörper) sir-2.3, homologous to mammalian SIRT4, is protective in both chemical ischemia and hyperactive channel induced necrosis. This work suggests a deleterious role of SIRT4 during ischemic processes in mammals that must be further investigated

7. This is the first study to identify an association between SIRT4 expression and decreased mitochondrial fission, which was driven by Drp1. SIRT4 inhibited Drp1 phosphorylation and weakened Drp1 recruitment to the mitochondrial membrane via an interaction with Fis-1.

8. miR (zeige MLXIP Antikörper)-15b is a negative regulator of stress-induced SIRT4 expression, thereby counteracting senescence associated mitochondrial dysfunction and regulating the SASP (zeige ASPRV1 Antikörper) and possibly organ aging, such as photoaging of human skin.

9. SIRT4 overexpression inhibits the proliferation of colorectal cancer cells in vitro and in vivo.

10. Data indicate that compared to non-neoplastic endometria (NNE), endometrial cancer (EC) showed SIRT7 (zeige SIRT7 Antikörper) mRNA overexpression, whereas SIRT1 (zeige SIRT1 Antikörper), SIRT2 (zeige SIRT2 Antikörper), SIRT4 and SIRT5 (zeige SIRT5 Antikörper) were underexpressed, and no significant differences were observed for SIRT3 (zeige SIRT3 Antikörper) and SIRT6 (zeige SIRT6 Antikörper).

Mouse (Murine) Sirtuin 4 (SIRT4) Interaktionspartner

1. Data suggest that high-fat diet (HFD) alters regulation of expression of sirtuins (Sirt4 and Sirt7 (zeige SIRT7 Antikörper)) and enzymes in NAD biosynthetic pathway (Tdo2 (zeige TDO2 Antikörper) and Nnmt (zeige NNMT Antikörper)); these alterations are more prominent in liver as compared to white adipose tissue or skeletal muscle; Tdo2 (zeige TDO2 Antikörper) and Nnmt (zeige NNMT Antikörper) may serve as markers of HFD consumption. (Tdo2 (zeige TDO2 Antikörper) = tryptophan 2,3-dioxygenase (zeige TDO2 Antikörper); Nnmt (zeige NNMT Antikörper) = nicotinamide N-methyltransferase (zeige NNMT Antikörper))

2. These findings identify a robust enzymatic activity for SIRT4, uncover a mechanism controlling branched-chain amino acid flux, and position SIRT4 as a crucial player maintaining insulin (zeige INS Antikörper) secretion and glucose homeostasis during aging.

3. miR (zeige MLXIP Antikörper)-497 modulates cardiac hypertrophy by targeting Sirt4 and may serve as a potential therapeutic substance in the course.

4. Until now, a mammalian cellular lipoamidase has not been characterized; this study discovered that SIRT4 can function with this enzymatic capacity in the mitochondria, and that PDH (zeige PDP Antikörper) is a biological substrate; compared to its catalytic efficiency for deacetylation, SIRT4 exhibits far superior enzymatic activity for lipoyl- and biotinyl-lysine modifications.

5. The results of this study indicated a critical and novel stress response role for SIRT4 in promoting proper glutamate (zeige GRIN1 Antikörper) transport capacity and protecting against excitotoxicity

6. regulates ATP levels via ANT2 (zeige SLC25A5 Antikörper) and a feedback loop involving AMPK (zeige PRKAA1 Antikörper)

7. these results highlight the tumor-suppressive role of SIRT4 in Myc (zeige MYC Antikörper)-induced B cell lymphoma and suggest that SIRT4 may be a potential target against Myc (zeige MYC Antikörper)-induced and/or glutamine (zeige GFPT1 Antikörper)-dependent cancers.

8. The enhanced fatty acid oxidation observed in SIRT4 knockout hepatocytes requires functional SIRT1 (zeige SIRT1 Antikörper), demonstrating a clear cross talk between mitochondrial and nuclear sirtuins.

9. Data uncover SIRT4 as an important component of the DNA damage response pathway that orchestrates a metabolic block in glutamine (zeige GFPT1 Antikörper) metabolism, cell cycle arrest, and tumor suppression.

10. SIRT4 represses fatty acid oxidation and stimulates lipogenesis. SIRT4 deacetylates and represses malonyl CoA decarboxylase, regulating malonyl coA levels.