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anti-Human IGFBP3 Antikörper:
anti-Mouse (Murine) IGFBP3 Antikörper:
anti-Rat (Rattus) IGFBP3 Antikörper:
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Human Monoclonal IGFBP3 Primary Antibody für IF, WB - ABIN968565
Campbell, Durham, Hayes, Suwanichkul, Powell: Insulin-like growth factor-binding protein-3 binds fibrinogen and fibrin. in The Journal of biological chemistry 1999
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Human Polyclonal IGFBP3 Primary Antibody für IHC (p), WB - ABIN3044421
Pu, Zheng, Zhang, Xiao, Xu, Liu, Wang, Wen, Zhou, Wu: Higher expression of mRNA and protein of insulin-like growth factor binding protein-3 in old rat penile tissues: implications for erectile dysfunction. in The journal of sexual medicine 2011
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Human Polyclonal IGFBP3 Primary Antibody für IHC (p), ELISA - ABIN3043859
Pu, Wen, Liu, Zheng, Xiao, Xu, Wang, Li, Zhang: shRNA constructs targeting IGFBP-3 alleviate age related erectile dysfunction in the rat. in The Journal of urology 2014
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Human Polyclonal IGFBP3 Primary Antibody für ELISA, WB - ABIN314305
Lin, Manson, Lee, Cook, Buring, Zhang: Intakes of calcium and vitamin D and breast cancer risk in women. in Archives of internal medicine 2007
Human Polyclonal IGFBP3 Primary Antibody für IF (p), IHC (p) - ABIN686497
Yuan, Han, Cong, Ge, Ma, Dai, Li, Bi: Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity. in International journal of nanomedicine 2014
insulin-like growth factor binding protein 3 exerts its ligand-independent action by antagonizing bone morphogenetic protein 2 (zeige BMP4 Antikörper) in zebrafish embryos
IGFBP-3 plays an important role in regulating pharyngeal cartilage and inner ear development and growth in zebrafish.
In longitudinal analysis, changes of FGF-21 (zeige FGF21 Antikörper) were not significantly related to changes of height, IGF-1 (zeige IGF1 Antikörper) or IGFBP-3 in obese children.
the concentrations of insulin (zeige INS Antikörper), IGF-1 (zeige IGF1 Antikörper), IGFBP-3 and their association with prostate size in patients with BPH (zeige GLI3 Antikörper)
Knockdown of HoxA13 (zeige HOXA13 Antikörper) caused the downregulation of long non-coding RNA HOTTIP and insulin growth factor-binding protein 3 (IGFBP-3) genes, indicating that both were targets of HoxA13 (zeige HOXA13 Antikörper).
We confirmed a previously reported association between circulating IGFBP-3 and diabetes risk in the older adult population
The results of this study, while not clearly supporting associations between these obesity-related biomarkers and renal cell carcinoma (zeige MOK Antikörper) risk, are consistent with previously reported findings for adiponectin, and suggest an association with elevated IGFBP-3 among obese individuals
our results reveal a new function of IGFBP2 (zeige IGFBP2 Antikörper), providing a novel insight into the mechanism of adipogenic differentiation and identifying a potential target mediator for improving adipose tissue engineering based on Wharton's jelly of the umbilical cord (WJCMSCs).
Increased IGFBP3 level as associated with decreased risk of frailty in men.
Report serum IGF1 (zeige IGF1 Antikörper)/IGFBP3 levels in relation to clinical/pathobiological features of squamous cell carcinomas of the head and neck.
Functional IGFBP-3 was significantly lower in postmenopausal women than in premenopausal women, for both patients with rheumatoid arthritis and controls. There was a significant decrease in plasma functional IGFBP-3 levels in postmenopausal RA in comparison to healthy premenopausal subjects.
study suggests high-order interactions of the IGFBP-3 rs2854744 AA genotype, BMI>/=24kg/m2, and DISI<9.85 mg/day on increased BC risk, particularly among postmenopausal women
endogenous (circulating and/or stromal) IGFBP-3 is stimulatory to adipose tissue expansion and enhances mammary tumor growth in immune-competent mice, potentially by suppressing T-cell infiltration into tumors.
High Igfbp3 expression is associated with skin squamous cell carcinoma.
The study shows that the anti-tumoral effect of IGFBP-3 is due to inhibition of the Wnt (zeige WNT2 Antikörper) pathway and depends upon the presence of CD44 (zeige CD44 Antikörper), a receptor protein known to modulate Wnt (zeige WNT2 Antikörper) signaling.
IGFBP-3 influences severity of DSS (zeige PMP22 Antikörper)-induced colitis.
our studies found that the deletion of IGFBP3 results in behavioral impairments that are associated with abnormal synaptic function and monoaminergic neurotransmission, which helps to characterize the critical role of IGFBP3 in the brain
IGFBP-3 is an aggravating factor during hepatic ischemia-repefusion injury.
An increase in IGFBP-3 post-trauma may play an important role in limiting trauma-induced inflammatory and apoptotic pathways leading to retinal damage.
Even though knockout of IGFBP-3 is associated with only a subtle phenotype under control conditions, our results reveal that loss of this gene has measurable effects on breast carcinogenesis and breast cancer metastasis.
Igfbp3 is a marker for culture-activated hepatic stellate cells and plays a role in HSC (zeige FUT1 Antikörper) migration.
Igfbp2 (zeige IGFBP2 Antikörper)-5 are expressed in distinct and complementary patterns during cochlear development.
The study demonstrates that hyaluronan acts as an anti-inflammatory molecule by down-regulating IFNAR1 and IFNAR2, the signaling molecules STAT1, STAT2, JAK1 and the downstream apoptotic targets IGFBP3 and IFIT3.
These data suggest that endogenous IGFBP-3 plays a role in intrinsic apoptosis by facilitating phosphorylation and nuclear export of Nur77 (zeige NR4A1 Antikörper) to the cytoplasm where it exerts its apoptotic effect.
The present study suggests that the insulin (zeige INS Antikörper) like growth factor (IGF) system or imbalances between IGF and IGF binding (zeige HTRA1 Antikörper) proteins may be involved in cystic ovary disease of cattle.
spatial and temporal patterns of expression of IGFBP-2 (zeige IGFBP2 Antikörper) and -3 were markedly altered in the placentomes of nuclear transfer pregnancies
stimulation of IGFBP-3 mRNA levels by mitogens is regulated through both the PI3K and MAPK (zeige MAPK1 Antikörper) pathways in bovine mammary epithelial cells
Preincubation of erythroid cells with thrombospondin 1 (zeige THBS1 Antikörper) eliminated the inhibitory activity of IGFBP-3
GH, IGF-I (zeige IGF1 Antikörper) and IGF-IBP3 regulated the growth and development traits in different growth period.
delivery of insulin-like growth factor-1 (IGF-1 (zeige IGF1 Antikörper), delivered at concentrations of 0, 10, 50, and 100 ng/mL) affects the endogenous expression of IGF-1 (zeige IGF1 Antikörper), its receptor (IGF-1R (zeige IGF1R Antikörper)), and a well known IGF-1 (zeige IGF1 Antikörper) binding protein (IGFBP-3) by articular chondrocytes
Multivariable adjusted analyses did not reveal a statistically significant linear relationship between IGF1 (zeige IGF1 Antikörper) or IGFBP3 concentrations or their molar ratio and risk of myocardial infarction
Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells.
IGF-I (zeige IGF1 Antikörper), IGF-II, and IGFBP-3 mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.
Increased oxidative stress from high glucose enhances IGFBP-3 expression, inducing apoptosis
Even though LRP-1 (zeige LRP1 Antikörper) mRNA and protein levels were dramatically reduced in LRP-1 (zeige LRP1 Antikörper)-silenced L6 cells compared with mock-silenced controls, rpIGFPB-3 suppressed proliferation rate to the same extent in both LRP-1 (zeige LRP1 Antikörper)-silenced and mock-silenced cultures.
cloning and sequencing; regulation of IGFBP-3 transcription by FSH (zeige BRD2 Antikörper) suggests a role for IGFBP-3 in follicular development that may be independent of IGF-I (zeige IGF1 Antikörper)
Follicle-stimulating hormone stimulation of IGFBP-3 transcription is mediated by cAMP via the PKA pathway and requires the P1-3 kinase and likely the MAPK (zeige MAPK1 Antikörper) pathways.
TAF4b may thus be the TFIID (zeige TBP Antikörper) component that binds to the TBP (zeige TBP Antikörper) site on the IGFBP-3 promoter and is essential for FSH (zeige BRD2 Antikörper) induction of IGFBP-3.
The results suggest that the expression of IGF2 and IGFBP3 mRNA in the adipose tissue of pigs exhibits specific developmental changes and different patterns between the two pig breeds.
allelic frequency of TAT (zeige C6orf134 Antikörper) in Chinese breeds was over 50%; allelic frequency of GGC (zeige GGCT Antikörper) was over 50% in all European breeds. TAT/TAT (zeige C6orf134 Antikörper) pigs scored higher in meat color than GGC/GGC (zeige GGCT Antikörper) pigs. results implied that IGFBP-3 may affect meat quality & carcass traits.
Data suggest that metabolism of IGFBP3, IGF1 (insulin-like growth factor I), and IGF2 (insulin-like growth factor II) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
, IGF-binding protein 3
, acid stable subunit of the 140 K IGF complex
, binding protein 29
, binding protein 53
, growth hormone-dependent binding protein
, insulin-like growth factor-binding protein 3
, insulin-like growth factor-binding protein (IGF-BP3)
, insulin-like growth factor binding protein-3
, insulin-like growth factor binding protein 3