MKNK2 Produkte
(MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2))
Kategorien
This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011].
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Ausgewählte MKNK2 Kategorien
MKNK2 Antikörper
High quality antibodies with extensive validation data.
MKNK2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene MKNK2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, PLA
Validierungen
- (7)
Kat. Nr.
ABIN516167
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF
Validierungen
- (5)
Kat. Nr.
ABIN516166
Menge
100 μg
Datenblatt
Datenblatt
Applikation
WB, IHC (p), IHC
Validierungen
- (3)
Kat. Nr.
ABIN6744440
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene MKNK2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6219467
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene MKNK2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
- (3)
Kat. Nr.
ABIN3093826
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Insect cells (Sf21)
Validierungen
- (2)
Kat. Nr.
ABIN5570743
Menge
5 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1310978
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren MKNK2 Produkten
: "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization." in: Molecular and cellular biology, Vol. 23, Issue 16, pp. 5692-705, (2003) (PubMed).: "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells." in: Molecular and cellular biology, Vol. 21, Issue 3, pp. 743-54, (2001) (PubMed).
: "Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2." in: Molecular and cellular biology, Vol. 21, Issue 16, pp. 5500-11, (2001) (PubMed).
Synonyme und alternative Namen zu MKNK2
MAP kinase interacting serine/threonine kinase 2 (MKNK2), MAP kinase interacting serine/threonine kinase 2 (mknk2), MAP kinase-interacting serine/threonine kinase 2 (Mknk2), MAP kinase interacting serine/threonine kinase 2b (mknk2b), MAP kinase interacting serine/threonine kinase 2 L homeolog (mknk2.L), MAP kinase interacting serine/threonine kinase 2 (Mknk2), MAP kinase interacting serine/threonine kinase 2a (mknk2a), 2010016G11Rik, fi34c11, GPRK7, gprk7, Gprk7, mknk2, MNK2, mnk2, Mnk2, wu:fb37e05, wu:fi34c11, wu:fi41e12, wz5090, zgc:55587Bezeichner auf Proteinebene für MKNK2
- G protein-coupled receptor kinase 7
- MAP kinase signal-integrating kinase 2
- MAP kinase-interacting serine/threonine-protein kinase 2
- MAPK signal-integrating kinase 2
- MAP kinase interacting serine/threonine kinase 2
- MAP kinase-interacting serine/threonine kinase 2
- mnk2
- MAP kinase interacting serine/threonine kinase 2a
Haben Sie etwas anderes gesucht?
- MKNK1
- MKLN1
- MKL2
- MKL1
- MKL
- MKKS
- MK13
- MK03
- MIXL1
- Mitogen-Activated Protein Kinase Kinase Kinase 3
- Mitogen-Activated Protein Kinase Kinase Kinase 13
- Mitogen-Activated Protein Kinase Kinase 4
- Mitogen-Activated Protein Kinase Kinase 2
- Mitogen-Activated Protein Kinase 1
- Mitogen-Activated Protein Kinase
- Mitochondrially Encoded NADH Dehydrogenase 4
- Mitochondrially Encoded ATP Synthase 8
- Mitochondrial Translation Elongation Factor EF-Ts Tsf1
- Mitochondrial Import Receptor Subunit TOM20 homolog
- Mitochondrial E3 Ubiquitin Protein Ligase 1
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