Mitogen-Activated Protein Kinase Kinase Kinase 3 Produkte
(Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3))
Kategorien
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively\; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
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Ausgewählte Mitogen-Activated Protein Kinase Kinase Kinase 3 Kategorien
Mitogen-Activated Protein Kinase Kinase Kinase 3 Antikörper
High quality antibodies with extensive validation data.
Mitogen-Activated Protein Kinase Kinase Kinase 3 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene Mitogen-Activated Protein Kinase Kinase Kinase 3 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC
Validierungen
- (4)
Kat. Nr.
ABIN7268652
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
IHC
Validierungen
- (3)
Kat. Nr.
ABIN7258882
Menge
200 μL
Datenblatt
Datenblatt
Reaktivität
Mouse, Rat
Applikation
WB, IHC (p)
Validierungen
- (4)
Kat. Nr.
ABIN3044008
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene Mitogen-Activated Protein Kinase Kinase Kinase 3 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7549217
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7557662
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1310214
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren Mitogen-Activated Protein Kinase Kinase Kinase 3 Produkten
: "Phenethyl isothiocyanate inhibits migration and invasion of human gastric cancer AGS cells through suppressing MAPK and NF-kappaB signal pathways." in: Anticancer research, Vol. 30, Issue 6, pp. 2135-43, (2010) (PubMed).: "PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway." in: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 36989-92, (2003) (PubMed).
: "Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3." in: Nature immunology, Vol. 5, Issue 1, pp. 98-103, (2003) (PubMed).
: "Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock." in: Nature cell biology, Vol. 5, Issue 12, pp. 1104-10, (2003) (PubMed).
: "Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 ..." in: The Journal of biological chemistry, Vol. 272, Issue 5, pp. 2668-74, (1997) (PubMed).
Synonyme und alternative Namen zu Mitogen-Activated Protein Kinase Kinase Kinase 3
mitogen-activated protein kinase kinase kinase 3 (MAP3K3), mitogen-activated protein kinase kinase kinase 3 (Map3k3), mitogen activated protein kinase kinase kinase 3 (Map3k3), mitogen-activated protein kinase kinase kinase 3 (map3k3), mitogen-activated protein kinase kinase kinase 3 L homeolog (map3k3.L), NPK1-related protein kinase 3 (NP3), ANP3, AtANP3, AW548911, F24F17.1, F24F17_1, map3k3, MAPKKK3, mapkkk3, MAPKKK12, MEKK3, Mekk3, mekk3, mKIAA4031, NPK1-related protein kinase 3Bezeichner auf Proteinebene für Mitogen-Activated Protein Kinase Kinase Kinase 3
- MAP/ERK kinase kinase 3
- MAPK/ERK kinase kinase 3
- MEK kinase 3
- MEKK 3
- mitogen activated protein kinase kinase kinase 3
- mitogen-activated protein kinase kinase kinase 3
- mitogen-activated protein kinase kinase kinase 3 L homeolog
- Arabidopsis NPK1-related protein kinase 3
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- Mitochondrially Encoded NADH Dehydrogenase 4
- Mitochondrially Encoded ATP Synthase 8
- Mitochondrial Translation Elongation Factor EF-Ts Tsf1
- Mitochondrial Import Receptor Subunit TOM20 homolog
- Mitochondrial E3 Ubiquitin Protein Ligase 1
- Mitochondrial ATPase Subunit 8
- MITF
- MITD1
- Mismatch Repair Protein 2
- MIS18 Binding Protein 1
- MIS12
- MIR7-3HG
- MIR22HG
- MIPOL1
- MIPEP
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