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MDM4-binding Protein Proteine

(Mdm4-binding Protein (MDM4))
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011].

14 Treffer

custom-made MDM4 Spezies: Maus Wirt: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Produktnummer ABIN7562343
 
custom-made MDM4 Spezies: Human Wirt: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Produktnummer ABIN7549390
 
MDM4 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Produktnummer ABIN7123869
 
MDM4 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses ELISA, WB
Produktnummer ABIN7123868
 
MDM4 Spezies: Human Wirt: Wheat germ Recombinant ELISA, WB, AP, AA
Produktnummer ABIN1310606
 
MDM4 Spezies: Human Wirt: Wheat germ Recombinant ELISA, WB, AP, AA
Produktnummer ABIN1310604
 
MDM4 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant ELISA, WB, SDS
Produktnummer ABIN7578137
 
custom-made MDM4 Spezies: Maus Wirt: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, WB, SDS
Produktnummer ABIN3131620
 
custom-made MDM4 Spezies: Human Wirt: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, WB, SDS
Produktnummer ABIN3083685
 
Rockland 009-001-s46s MDM4 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant >75% WB
Produktnummer ABIN6700263
Rockland Original
MDM4 Spezies: Ratte Wirt: Hefe Recombinant > 90 % ELISA
Produktnummer ABIN7590301
 
MDM4 Spezies: Rind (Kuh) Wirt: Hefe Recombinant > 90 % ELISA
Produktnummer ABIN7588181
 
MDM4 Spezies: Xenopus laevis Wirt: Hefe Recombinant > 90 % ELISA
Produktnummer ABIN1677564
 
MDM4 Spezies: Zebrafisch (Danio rerio) Wirt: Hefe Recombinant > 90 % ELISA
Produktnummer ABIN1678275
 
  • Typ Protein
    • Protein
  • Anwendung
    • ELISA
    • Western Blotting (WB)
    • SDS-PAGE (SDS)
    • Affinity Purification (AP)
    • Antibody Array (AA)
  • Reaktivität
    • Human
    • Mouse
    • Cow
    • Rat
    • Xenopus laevis
    • Zebrafish (Danio rerio)
  • Abbildungen verfügbar
  • Carrier free only
  • Wirt
    • Escherichia coli (E. coli)
    • Yeast
    • Cell-free protein synthesis (CFPS)
    • HEK-293 Cells
    • Wheat germ
  • Bindungsspezifität
    • AA 1-490
    • AA 1-137
    • AA 1-489
    • AA 1-300
    • AA 1-475
    • AA 1-491
    • AA 1-496
    • AA 381-490
  • Konjugat
    • His tag
    • GST tag
    • Strep Tag
  • Protein-Typ
    • Recombinant
  • Format
    • Lyophilized
    • Liquid
  • Grade
    • custom-made
  • Hersteller
    • antibodies-online
    • CUSABIO
    • Rockland

Aliase für MDM4-binding Protein Proteine

MDM4, p53 regulator S homeolog (mdm4.S) Proteine
MDM4, p53 regulator (MDM4) Proteine
MDM4, p53 regulator (Mdm4) Proteine
MDM4, p53 regulator (mdm4) Proteine
transformed mouse 3T3 cell double minute 4 (Mdm4) Proteine
4933417N07Rik Proteine
AA414968 Proteine
AL023055 Proteine
AU018793 Proteine
AU021806 Proteine
C85810 Proteine
HDMX Proteine
mdmx Proteine
MDMX Proteine
Mdmx Proteine
MRP1 Proteine
wu:fa09h09 Proteine
wu:fi33d10 Proteine
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