MDM4-binding Protein Produkte
(Mdm4-binding Protein (MDM4))
Kategorien
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011].
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Ausgewählte MDM4-binding Protein Kategorien
MDM4-binding Protein Antikörper
High quality antibodies with extensive validation data.
MDM4-binding Protein ELISA Kits
Reliable ELISA kits for a wide range of species.
MDM4-binding Protein Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene MDM4-binding Protein Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IF, IP
Validierungen
- (8)
Kat. Nr.
ABIN948119
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC, ICC
Validierungen
- (2)
- (4)
Kat. Nr.
ABIN969282
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IF, IHC (p)
Validierungen
- (4)
Kat. Nr.
ABIN1499354
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene MDM4-binding Protein ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN1381305
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6951175
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene MDM4-binding Protein Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7123869
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7123868
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1310604
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren MDM4-binding Protein Produkten
: "MDM4 expression in fibrolamellar hepatocellular carcinoma." in: Oncology reports, (2019) (PubMed).: "MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability." in: Molecular cancer, Vol. 16, Issue 1, pp. 55, (2017) (PubMed).
: "MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response." in: Oncogene, (2015) (PubMed).
: "Searching for Dual Inhibitors of the MDM2-p53 and MDMX-p53 Protein-Protein Interaction by a Scaffold-Hopping Approach." in: Chemical biology & drug design, Vol. 86, Issue 2, pp. 180-9, (2015) (PubMed).
: "Protumorigenic role of Timeless in hepatocellular carcinoma." in: International journal of oncology, Vol. 46, Issue 2, pp. 597-606, (2014) (PubMed).
: "EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma." in: Hepatology (Baltimore, Md.), Vol. 59, Issue 5, pp. 1886-99, (2014) (PubMed).
: "Stress-induced isoforms of MDM2 and MDM4 correlate with high-grade disease and an altered splicing network in pediatric rhabdomyosarcoma." in: Neoplasia (New York, N.Y.), Vol. 15, Issue 9, pp. 1049-63, (2013) (PubMed).
: "MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress." in: Molecular and cellular biology, Vol. 32, Issue 7, pp. 1214-25, (2012) (PubMed).
: "Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein." in: The Journal of biological chemistry, Vol. 287, Issue 25, pp. 20898-903, (2012) (PubMed).
: "p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors." in: PLoS ONE, Vol. 7, Issue 5, pp. e37776, (2012) (PubMed).
Synonyme und alternative Namen zu MDM4-binding Protein
MDM4, p53 regulator S homeolog (mdm4.S), MDM4, p53 regulator (MDM4), MDM4, p53 regulator (Mdm4), MDM4, p53 regulator (mdm4), transformed mouse 3T3 cell double minute 4 (Mdm4), 4933417N07Rik, AA414968, AL023055, AU018793, AU021806, C85810, HDMX, mdmx, MDMX, Mdmx, MRP1, wu:fa09h09, wu:fi33d10Bezeichner auf Proteinebene für MDM4-binding Protein
- double minute 4 protein
- mdm2-like p53-binding protein
- p53-binding protein Mdm4
- protein Mdm4
- MDM4-related protein 1
- double minute 4, human homolog of; p53-binding protein
- protein Mdmx
- Mdm4, transformed 3T3 cell double minute 4, p53 binding protein
- double minute 4 homolog
- transformed mouse 3T3 cell double minute 4
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