anti-GCK (GCK) Antikörper

Bezeichnung:: anti-Glucokinase (Hexokinase 4) Antikörper (GCK)

Auf www.antikoerper-online.de finden Sie aktuell 129 Glucokinase (Hexokinase 4) (GCK) Antikörper von 23 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen GCK Proteine (62) und GCK Kits (60) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 265 GCK Produkte verfügbar.

Synonyme:: BA4487, FGQTL3, GCK, gck-A, Gk, glk, Gls006, glucokinase, GLUKA, hhf3, hk4, hkiv, hxkp, LGLK, mody2, RNGK2

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	GCK	2645	P35557
	GCK	103988	P52792
	GCK	24385	P17712
Alle Spezies anzeigen Weitere Synonyme anzeigen

Meistgesuchte Reaktivitäten zu anti-GCK (GCK) Antikörper

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anti-Human GCK Antikörper:

anti-Mouse (Murine) GCK Antikörper:

anti-Rat (Rattus) GCK Antikörper:

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Verknüpfte Pathways mit anti-GCK Antikörper

Regulation of Carbohydrate Metabolic Process

Weitere Produktkategorien zu GCK Antikörper

Am meisten referenzierte anti-GCK Antikörper

Human Monoclonal GCK Primary Antibody für ELISA, WB - ABIN966192 : Barbetti, Cobo-Vuilleumier, Dionisi-Vici, Toni, Ciampalini, Massa, Rodriguez-Bada, Colombo, Lenzi, Garcia-Gimeno, Bermudez-Silva, Rodriguez de Fonseca, Banin, Aledo, Baixeras, Sanz, Cuesta-Muñoz: Opposite clinical phenotypes of glucokinase disease: Description of a novel activating mutation and contiguous inactivating mutations in human glucokinase (GCK) gene. in Molecular endocrinology (Baltimore, Md.) 2009 (PubMed)
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Human Monoclonal GCK Primary Antibody für ELISA, WB - ABIN969172 : Yoshida, Kato, Yokoi, Oguri, Watanabe, Metoki, Yoshida, Satoh, Aoyagi, Nishigaki, Nozawa, Yamada: Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. in International journal of molecular medicine 2009 (PubMed)
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Cow (Bovine) Polyclonal GCK Primary Antibody für WB - ABIN2788816 : Tian, Liu, Wang, Dong, Su, Ma, Zhang: Anti-diabetes effect of chronic intermittent hypobaric hypoxia through improving liver insulin resistance in diabetic rats. in Life sciences 2016 (PubMed)
Human Polyclonal GCK Primary Antibody für FACS, IF - ABIN411493 : Huang, Chou, Lee, Chen, Chen, Tao, Shih: MicroRNA-130a can inhibit hepatitis B virus replication via targeting PGC1α and PPARγ. in RNA (New York, N.Y.) 2015 (PubMed)
Human Polyclonal GCK Primary Antibody für IF (p), IHC (p) - ABIN734558 : Wang, Liu, Chen, Duan, Chen, Xi: Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus. in Journal of diabetes research 2017 (PubMed)

Weitere Antikörper gegen GCK Interaktionspartner

Human Glucokinase (Hexokinase 4) (GCK) Interaktionspartner

La variante confirmada of the glucokinase gene para esta (zeige RPL11 Antikörper) familia es c.148C>T, p.His50Tyr. Tiene caracter patogenico, dado que (zeige DBT Antikörper) produce una disminucion de la actividad enzimatica de GCK y ha sido reportada en la literatura
described the clinical and genetic presentation of four families with activating GCK mutations The clinical phenotype of the GCK activating mutation carriers was heterogeneous, the severity of symptoms and age at presentation varied markedly between affected individuals, even within the same family.
the contribution of the Maturity Onset Diabetes of the Young gene GCK in the etiology of 23 unrelated Tunisian families
GCK-dependent glycolysis regulates Treg cell migration.
Mutations in the GCK gene were identified in 79 out of 177.
GCK GCK GCK GCK
GCK gene mutations (pathogenic or likely pathogenic variants) and a novel intronic variant of uncertain significance (c.208 + 3A>T) were identified in 13/54 probands (24%).
Data suggest that hepatic glucokinase activity is regulated by reversible binding to specific inhibitor protein glucokinase regulatory protein (GKRP (zeige GCKR Antikörper)) and by binding to activator proteins such as 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase (PFK2 (zeige PFKFB3 Antikörper)/FBP2 (zeige KHSRP Antikörper)); changes in glucokinase expression and activity are associated with poorly controlled type 2 diabetes and nonalcoholic fatty liver disease. [REVIEW]
GCK expression is regulated by nutrient-sensing O-linked beta-N-acetylglucosaminylation cycling in liver.
GCK mutations are associated with MODY2.

Mouse (Murine) Glucokinase (Hexokinase 4) (GCK) Interaktionspartner

Glucokinase governs an alpha-cell metabolic pathway that suppresses secretion at or above normoglycemic levels; abnormal suppression of glucagon (zeige GCG Antikörper) secretion deregulates hepatic glucose metabolism and, over time, induces a pre-diabetic phenotype.
GCK-dependent glycolysis regulates Treg cell migration.
GCK expression is regulated by nutrient-sensing O-linked beta-N-acetylglucosaminylation cycling in liver.
Absence of Gck expression did not prevent the glucose responsiveness of glucose-excited or glucose-inhibited Sf1 (zeige SF1 Antikörper) neurons in either sex. Thus Gck in the VMN plays a sex-specific role in the glucose-dependent control of autonomic nervous activity; this is, however, unrelated to the control of the firing activity of classical glucose-responsive neurons.
Using a mutant GCK gene (GCK 262) with a knocked out cytosine at position 2643 results in lower protein expression and more ubiquitination-led protein degradation compared with wild-type GCK (GCK 261)
lncLGR facilitates the recruitment of hnRNPL (zeige HNRNPL Antikörper) to the GCK promoter and suppresses GCK transcription.
Given that acetylated GKRP (zeige GCKR Antikörper) may affiliate with type-2 diabetes mellitus (T2DM), understanding the mechanism of GKRP (zeige GCKR Antikörper) acetylation in the liver could reveal novel targets within the GK-GKRP (zeige GCKR Antikörper) pathway, for treating T2DM and other metabolic pathologies.
These results suggest a mechanism for integrative control over GCK activation and, therefore, glucose metabolism and insulin (zeige INS Antikörper) secretion through regulation of cytoplasmic Ca(2 (zeige CA2 Antikörper)+) levels.
GHR (zeige GHR Antikörper) knockdown caused increased glucokinase mRNA and protein levels.
results suggest that chronic suppression of hepatic glucokinase has a small influence on intertissue (liver-to-BAT (zeige BAAT Antikörper) as well as liver-to-beta-cell) metabolic communication

Rainbow Trout (Oncorhynchus mykiss) Glucokinase (Hexokinase 4) (GCK) Interaktionspartner

This study using immunoreactive techniques, we have demonstrated in those specific areas of the rainbow trout brain previously described as glucosensor the presence of glucokinase in different cell types.

Xenopus laevis Glucokinase (Hexokinase 4) (GCK) Interaktionspartner

GKRP (zeige GCKR Antikörper) binds to a super-open conformation of GK mainly through hydrophobic interaction, inhibiting the GK activity by locking a small domain of GK.

GCK Antigen-Profil

Beschreibung des Gens

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

Alternative names and synonyms associated with GCK

glucokinase (GCK) Antikörper
glucokinase (Gck) Antikörper
glucokinase (glcK) Antikörper
glucokinase (Bphyt_1025) Antikörper
glucokinase (Halhy_6548) Antikörper
glucokinase (gk) Antikörper
glucokinase (hexokinase 4) L homeolog (gck.L) Antikörper
glucokinase (hexokinase 4) (gck) Antikörper

BA4487 Antikörper
FGQTL3 Antikörper
GCK Antikörper
gck-A Antikörper
Gk Antikörper
glk Antikörper
Gls006 Antikörper
glucokinase Antikörper
GLUKA Antikörper
hhf3 Antikörper
hk4 Antikörper
hkiv Antikörper
hxkp Antikörper
LGLK Antikörper
mody2 Antikörper
RNGK2 Antikörper

Bezeichner auf Proteinebene für GCK

ATP:D-hexose 6-phosphotransferase , HK IV , glucokinase , hexokinase D, pancreatic isozyme , hexokinase type IV , hexokinase-4 , hexokinase-D , hexokinase 4 , glucokinase (hexokinase 4, maturity onset diabetes of the young 2) , HK4

GENE ID	SPEZIES
2645	Homo sapiens
103988	Mus musculus
606490	Canis lupus familiaris
616576	Bos taurus
1087979	Bacillus anthracis str. Ames
2797963	Listeria monocytogenes serotype 4b str. F2365
3728664	Carboxydothermus hydrogenoformans Z-2901
6284349	Burkholderia phytofirmans PsJN
10590758	Haliscomenobacter hydrossis DSM 1100
100037406	Felis catus
100135866	Oncorhynchus mykiss
378602	Xenopus laevis
100124905	Xenopus (Silurana) tropicalis
24385	Rattus norvegicus
430370	Gallus gallus
100051836	Equus caballus
100514142	Sus scrofa
100717630	Cavia porcellus
100341946	Oryctolagus cuniculus

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