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anti-Human SUN1 Antikörper:
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Human Polyclonal SUN1 Primary Antibody für ICC, IF - ABIN4356964
Ramachandran, Pucadyil, Liu, Acharya, Leonard, Lukiyanchuk, Schmid: Membrane insertion of the pleckstrin homology domain variable loop 1 is critical for dynamin-catalyzed vesicle scission. in Molecular biology of the cell 2009
Show all 9 Pubmed References
Human Monoclonal SUN1 Primary Antibody für ICC, IF - ABIN1042680
Hodzic, Yeater, Bengtsson, Otto, Stahl: Sun2 is a novel mammalian inner nuclear membrane protein. in The Journal of biological chemistry 2004
Human Polyclonal SUN1 Primary Antibody für WB - ABIN525108
Jung, Nobumori, Goulbourne, Tu, Lee, Tatar, Wu, Yoshinaga, de Jong, Coffinier, Fong, Young: Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration. in Proceedings of the National Academy of Sciences of the United States of America 2013
Human Polyclonal SUN1 Primary Antibody für ICC, IF - ABIN4356962
Chaumet, Wright, Seet, Tham, Gounko, Bard: Nuclear envelope-associated endosomes deliver surface proteins to the nucleus. in Nature communications 2015
Coiled-coil domains of SUN-1 are required for oligomerization and retention of the protein in the nuclear envelope, especially at later stages of female gametogenesis.
POT-1 has a role in anchoring telomeres through SUN-1 at the nuclear periphery.
This suggests that SUN-1 phosphorylation is critical to delaying meiosis in response to perturbed synapsis. SUN-1 may be an integral part of a checkpoint system to monitor establishment of the obligate crossover
The dynamics of matefin/SUN-1 aggregates remained unchanged throughout leptonene/zygotene, despite the progression of pairing.
[REVIEW]functions of these KASH/SUN protein pairs across spatial and temporal C. elegans development
Data show that ZYG-12 is immobile at the outer nuclear membrane and that SUN-1 is sufficient to localize ZYG-12 in cells.
Data suggest that the properties of the nuclear envelope are altered during the time window when homologs are sorted and Matefin/SUN-1 aggregates form, thereby controling the movement, homologous pairing and interhomolog recombination of chromosomes.
Mechanisms of SUN1 Oligomerization in the Nuclear Envelope
While Sun1 and Sun2 in HeLa cells are each able to bind KASH-domains, Sun1 is more efficiently incorporated into LINC complexes under normal growth conditions. Furthermore, the balance of Sun1 and Sun2 incorporated into LINC complexes is cell type-specific and is correlated with SRF/Mkl1-dependent gene expression.
Low SUN1 expression is associated with HIV infections.
Thus, AID is a conserved functional domain in SUN proteins and this work provides the structural evidence to support the conversation of the AID-mediated autoinhibition of SUN proteins.
SUN1/SUN2 may function redundantly in early HIV-1 infection steps and therefore influence HIV-1 replication and pathogenesis.
wndchrm revealed a consistent negative correlation between SUN1 expression and the size of nucleoli in human breast cancer tissues.
Nuclear envelope associated endosome-mediated transfer depends on the nuclear envelope proteins SUN1 and SUN2, as well as the Sec61 translocon complex.
SUN1 plays a role in hnRNP-involved mRNA export.
An important role for SUN1 and SUN2 in muscle disease pathogenesis.
these data support a model whereby mitotic phosphorylation of SUN1 disrupts interactions with nucleoplasmic binding partners, promoting disassembly of the nuclear lamina and, potentially, its chromatin interactions
The Caenorhabditis elegans lamin, LMN-1, is required for nuclear migration and interacts with the nucleoplasmic domain of the SUN protein UNC-84.
Results highlight the interactions at the nuclear envelope where mutations in the EMD and TMPO gene in combination with mutations in SUN1 have an impact on several components of the network.
Farnesylation of progerin enhances its interaction with SUN1 and reduces SUN1 mobility.
Codepletion of SUN1/2 slows cell proliferation and results in an accumulation of morphologically defective and disoriented mitotic spindles.
Reduction of SUN1 overaccumulation in LMNA mutant fibroblasts and in cells derived from HGPS patients corrected nuclear defects and cellular senescence.
These results demonstrate that the interplay between SUN1 and farnesylated prelamin A contributes to nuclear positioning in human myofibers and may be implicated in pathogenetic mechanisms.
POM121 and Sun1 interact transiently to promote early steps of interphase nuclear pore complexes assembly
Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development
perturbations in lamin A-SUN1 and SUN2 protein interactions may underlie the opposing effects of EDMD and HGPS mutations on nuclear and cellular mechanics
Describes cloning and function of C. elegans unc-84 and cloning of human orthologs.
Results provide evidence that SUN1 and KASH5 are essential factors in the regulation of meiotic resumption and spindle formation.
A cell-type-specific role for Sun1 and Sun2 in nucleokinesis during cerebellar development, is reported.
ablation of the kinase CDK2 alters the nuclear envelope in mouse spermatocytes, and that the proteins SUN1, KASH5 (also known as CCDC155) and lamin C2 show an abnormal cap-like distribution facing the centrosome.
our results clearly indicate that SUN1 and SUN2, at least partially, fulfill redundant meiotic functions
Sun1, a component of LINC complexes, but not A-type lamins, which interact with LINC complexes at the nuclear envelope, participate in cone nuclei positioning.
Sun1 has a role in DNA damage response.
It was shown KASH5 possesses hitherto unknown KASH-related sequences that directly interacted with SUN1 and mediated telomere localization. KASH5 interacted with the microtubule-associated dynein- dynactin complex.
These findings implicate Sun1 protein accumulation as a common pathogenic event in Lmna(-/-), LmnaDelta9 mice, models for Emery-Dreifuss muscular dystrophy and Hutchinson-Gilford progeria disorders.
Syne-2, SUN1 and SUN2 play critical roles during interkinetic nuclear migration and photoreceptor cell migration in the mouse retina development.
The Sun1 serves as a 'structural bridge' connecting the nuclear interior with the actin cytoskeleton.
SUN1 interacts with nuclear lamin A and cytoplasmic nesprins (nesprin-1 and nesprin-2)to provide a physical connection between the nuclar lamina and the cytoskeleton.
SUN1 and SUN2 may form a physical interaction between the nuclear envelope and the centrosome
Sun1-/- P14 testes are repressed for the expression of reproductive genes and have no detectable piRNA
These results clearly indicate that SUN1 and SUN2 function critically in skeletal muscle cells for Syne-1 localization at the nuclear envelope, which is essential for proper myonuclear positioning.
The study indicated that the SUN1-KASH complexes mediate the coupling between the nucleus and the centrosome and provide anchors in the nuclear envelope for cytoplasmic dynein/dynactin during neuronal migration.
This gene is a member of the unc-84 homolog family and encodes a nuclear nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Alternatively spliced transcript variants have been described.
SUN domain-containing protein 1
, Sad1 unc-84 domain protein 1
, protein unc-84 homolog A
, sad1/unc-84 protein-like 1
, unc-84 homolog A