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Human Polyclonal SPAG5 Primary Antibody für ICC, IF - ABIN261715
Shrestha, Draviam: Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK. in Current biology : CB 2013
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Polyclonal SPAG5 Primary Antibody für WB - ABIN540858
Chang, Huang, Chen, Chen, Fan, Chu, Lin, Yang: Cloning and characterization of hMAP126, a new member of mitotic spindle-associated proteins. in Biochemical and biophysical research communications 2001
The authors show that the Astrin-SKAP (zeige KNSTRN Antikörper) complex binds synergistically to microtubules with the Ndc80 (zeige NDC80 Antikörper) complex to form an integrated interface.
Data show that aurora-B (zeige AURKB Antikörper) regulates end-on conversion in human cells and indicate a late role for SPAG5 protein (Astrin)-SKAP (zeige KNSTRN Antikörper) complex in the end-on conversion process.
Low SPAG5 expression is associated with low chemotherapy sensitivity in breast cancer.
findings reveal a direct physical link between two important regulators of mitotic progression and demonstrate the critical role of the NuMA (zeige NUMA1 Antikörper)-Astrin interaction for accurate cell division.
Mechanistically, Plk1 (zeige PLK1 Antikörper) acts as an upstream kinase for Astrin phosphorylation by Cdk1 (zeige CDK1 Antikörper) and targeting phospho-Astrin to KTs, leading to the recruitment of outer KT components, such as Cenp-E (zeige CENPE Antikörper), and the stable attachment of spindles to KTs.
Results showed a progression-driving role of SPAG5 in prostate cancer which can be regulated by miR (zeige MLXIP Antikörper)-539.
Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP (zeige KNSTRN Antikörper) and Astrin have been reported.
SPAG5 upregulation relates to poor prognosis in cervical cancer patients, and SPAG5 is a regulator of mTOR (zeige FRAP1 Antikörper) activity during taxol treatment in cervical cancer.
Astrin acts as a mitotic phosphoprotein during the regulation of mitosis.
Study identifies astrin as an essential negative mTORC1 regulator in the cellular stress response. Upon stress, astrin inhibits mTORC1 association and recruits the mTORC1 component raptor (zeige RPTOR Antikörper) to stress granules, thereby preventing mTORC1-hyperactivation-induced apoptosis.
cloning and genomic structure of mastrin; mastrin protein was demonstrated to localize to mitotic spindles during mitosis[masatrin]
Loss-of-function of Astrin by RNAi and overexpression of the coiled-coil domain results in spindle disorganization, chromosome misalignment and meiosis progression arrest.
This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles.
sperm associated antigen 5
, sperm-associated antigen 5-like
, mitotic spindle associated protein p126
, mitotic spindle coiled-coil related protein
, mitotic spindle-associated protein p126
, sperm-associated antigen 5
, microtubule-associated protein