SPAG5 Antikörper (AA 875-925)

Produktnummer ABIN7451646

Produktdetails anti-SPAG5 Antikörper

Target: SPAG5 (Sperm Associated Antigen 5 (SPAG5))

Bindungsspezifität: AA 875-925

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPAG5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Verwendungszweck: Rabbit anti-Astrin/MAP126 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 875 and 925

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu SPAG5

Target: SPAG5 (Sperm Associated Antigen 5 (SPAG5))

Andere Bezeichnung: Astrin/MAP126 (SPAG5 Produkte)

Synonyme: SPAG5 antikoerper, DEEPEST antikoerper, MAP126 antikoerper, hMAP126 antikoerper, AI874642 antikoerper, D11Bhm180e antikoerper, Deepest antikoerper, Mastrin antikoerper, S17 antikoerper, sperm associated antigen 5 antikoerper, sperm-associated antigen 5 antikoerper, SPAG5 antikoerper, LOC739263 antikoerper, Spag5 antikoerper

Hintergrund: Background: Astrin/MAP126 has been identified as a mitotic spindle-associated protein essential for centrosome integrity and the progression through mitosis. Astrin/MAP126 interacts with Ninein and Aurora-A at the centrosome. Ninein, but not Aurora-A, appears to be required for proper localization of Astrin/MAP126 to the centrosome during S and G2 phase. A pool of Astrin/MAP126 also localizes to the outer kinetochore where it plays an essential role in chromatid adhesion and chromosome congression and segregation. The localization of Astrin/MAP126 to the spindle pole and kinetochore has been shown to be dependent on its phosphorylation by glycogen synthase kinase 3beta (GSK3beta).

Gen-ID: 10615

NCBI Accession: NP_006452

UniProt: Q96R06

Pathways: M Phase