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LOX Proteine

(Lysyl Oxidase (LOX))
The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010].

22 Treffer

LOX Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant SDS, WB, Imm, ELISA
Produktnummer ABIN7951119
503,00 €
Zzgl. Versandkosten 20,00 € und MwSt
100 μg (Weitere Mengeneinheiten)
Lieferung nach: Deutschland
Lieferung in 12 bis 17 Werktagen
 
LOX Spezies: Maus Wirt: Bacteria Recombinant
Produktnummer ABIN7820127
361,90 €
Zzgl. Versandkosten 20,00 €, Trockeneispauschale 20,00 € sowie MwSt
100 μg
Lieferung nach: Deutschland
Lieferung in 4 bis 5 Werktagen
 
  • Typ Protein
    • Protein
  • Anwendung
    • Western Blotting (WB)
    • SDS-PAGE (SDS)
    • ELISA
    • Immunogen (Imm)
    • Positive Control (PC)
    • Activity Assay (AcA)
    • Antibody Production (AbP)
    • Cell Culture (CC)
    • Standard (STD)
  • Reaktivität
    • Human
    • Mouse
    • Chicken
    • Cow
    • Pig
    • Rat
  • In Publikationen zitiert
  • Abbildungen verfügbar
  • Carrier free only
  • Wirt
    • Escherichia coli (E. coli)
    • Yeast
    • Bacteria
    • Baculovirus infected Insect Cells
    • HEK-293 Cells
    • HEK-293F Cells
  • Bindungsspezifität
    • AA 169-417
    • AA 213-417
    • AA 1-249
    • AA 163-411
    • AA 170-418
    • AA 172-420
    • AA 174-417
    • AA 207-411
  • Konjugat
    • His tag
    • His tag,GST tag
    • Unkonjugiert
    • DYKDDDDK-His Tag
    • GST tag
    • His-IF2DI Tag
    • His-SUMO Tag,MYC tag
    • MBP tag,His tag
    • Myc-DYKDDDDK Tag
  • Protein-Typ
    • Recombinant
  • Format
    • Lyophilized
    • Liquid
  • Biologische Aktivität
    • Biologically Active
  • Hersteller
    • antibodies-online
    • CUSABIO
    • Signalway
    • OriGene
    • ProteoGenix
    • Abbexa
    • Cloud-Clone

Aktuelle Publikationen für unsere LOX Proteine

Pilecki, Holm, Schlosser, Moeller, Wohl, Zuk, Heumüller, Wallis, Moestrup, Sengle, Holmskov, Sorensen: "Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation." in: The Journal of biological chemistry, Vol. 291, Issue 3, pp. 1103-14, (2016) (PubMed).

Kondala, Puri, Banka, Sachdeva, Sakhuja: "Short-term prognosis of potential celiac disease in Indian patients." in: United European gastroenterology journal, Vol. 4, Issue 2, pp. 275-80, (2016) (PubMed).

Tsukasaki, Hamada, Okamoto, Nagashima, Terashima, Komatsu, Win, Okamura, Nitta, Yasuda, Penninger, Takayanagi: "LOX Fails to Substitute for RANKL in Osteoclastogenesis." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 32, Issue 3, pp. 434-439, (2016) (PubMed).

Cox, Rumney, Schoof, Perryman, Høye, Agrawal, Bird, Latif, Forrest, Evans, Huggins, Lang, Linding, Gartland, Erler: "The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase." in: Nature, Vol. 522, Issue 7554, pp. 106-10, (2015) (PubMed).

Miller, Morton, Pinese, Saturno, Jamieson, McGhee, Timpson, Leach, McGarry, Shanks, Bailey, Chang, Oien, Karim, Au, Steele, Carter, McKay, Anderson, Evans, Marais, Springer, Biankin, Erler, Sansom: "Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy." in: EMBO molecular medicine, Vol. 7, Issue 8, pp. 1063-76, (2015) (PubMed).

Richter, Dayaram, Gilmartin, Ganji, Pemmasani, Van Der Key, Shohet, Donehower, Kumar: "WIP1 phosphatase as a potential therapeutic target in neuroblastoma." in: PLoS ONE, Vol. 10, Issue 2, pp. e0115635, (2015) (PubMed).

Zhao, Sagare, Ma, Halliday, Kong, Kisler, Winkler, Ramanathan, Kanekiyo, Bu, Owens, Rege, Si, Ahuja, Zhu, Miller, Schneider, Maeda, Maeda, Sugawara, Ichida, Zlokovic: "Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance." in: Nature neuroscience, Vol. 18, Issue 7, pp. 978-87, (2015) (PubMed).

Arnold, Kent, Hogarth, Schlatt, Prasad, Haenisch, Walsh, Muller, Griswold, Amory, Isoherranen: "Importance of ALDH1A enzymes in determining human testicular retinoic acid concentrations." in: Journal of lipid research, Vol. 56, Issue 2, pp. 342-57, (2015) (PubMed).

Wilson, Bradley, Shaw, Wagenmakers: "Paxillin and focal adhesion kinase colocalise in human skeletal muscle and its associated microvasculature." in: Histochemistry and cell biology, Vol. 142, Issue 3, pp. 245-56, (2014) (PubMed).

Nandhu, Hu, Cole, Erdreich-Epstein, Rodriguez-Gil, Viapiano: "Novel paracrine modulation of Notch-DLL4 signaling by fibulin-3 promotes angiogenesis in high-grade gliomas." in: Cancer research, Vol. 74, Issue 19, pp. 5435-48, (2014) (PubMed).

Aliase für LOX Proteine

lysyl oxidase (LOX) Proteine
lysyl oxidase (lox) Proteine
lysyl oxidase a (loxa) Proteine
lysyl oxidase L homeolog (lox.L) Proteine
lysyl oxidase (Lox) Proteine
AI893619 Proteine
H-rev142 Proteine
LOX Proteine
lox Proteine
MGC146507 Proteine
Rrg1 Proteine
TSC-160 Proteine
Xlox Proteine
zgc:77447 Proteine
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