MASP2 Proteine (MASP2)

Human Mannan-Binding Lectin serine Peptidase 2 (MASP2) Interaktionspartner

1. Genetically determined MASP-2 levels seem to have a two-edge effect in HIV and probably HCV/HBV coinfection, whereas low levels increase the susceptibility to infection, but on the other side protects against AIDS.

2. MASP-2 was not associated with adverse cardiovascular outcomes in diabetics.

3. This is the first comprehensive meta-analysis indicates that the MASP-2 functional gene (rs72550870) polymorphism is not associated with the infection diseases, and the key functional gene polymorphism of rs72550870 did not increase susceptibility to the infection diseases.

4. This study suggests that hMASP-2 can induce a protective efficacy in BCG (zeige SLC11A1 Proteine)-infected rabbit skin models, which affects both the progress of lesions and the survival of the mycobacteria within them.

5. The ficolin-3 (zeige FCN3 Proteine)/MASP-2 complex was significantly lower in the cardiac syndrome X patients compared to controls.

6. MASP-1 (zeige MASP1 Proteine) and MASP-2 are activated during blood clotting. This activation is triggered by activated platelets and by the generation of fibrin during thrombotic reactions in vitro and in vivo, and may represent a novel activation/amplification mechanism in thromboinflammation.

7. MBL2 (zeige MBL2 Proteine) and MASP2 deficiencies protect against the development of systemic inflammatory response after pediatric cardiac surgery.

8. Data show that the vector expressing mannose-binding lectin (zeige MBL2 Proteine) associated protein 19 (MAp19) has been prepared successfully, and can express the target protein (MAp19) in the eukaryotic cells (HeLa cells).

9. polymorphism of MASP-2 (rs6695096) gene was associated with susceptibility to tuberculosis.

10. Polymorphisms of mannose-binding lectin (zeige MBL2 Proteine) (rs7096206) and MASP-2 (rs2273346 and rs6695096) were associated with the susceptibility of tuberculosis, and there were gene-gene interactions among them.

Mouse (Murine) Mannan-Binding Lectin serine Peptidase 2 (MASP2) Interaktionspartner

1. this study shows that MASP-2 contributes to the development of collagen Ab-induced arthritis

2. We induced anti-myeloperoxidase vasculitis in mice and showed that neither MASP-2- nor properdin-deficient mice were protected, suggesting that alternative pathway activation does not require properdin or the lectin pathway.

3. Mannan-binding lectin-associated serine protease 2 is critical for the development of renal ischemia reperfusion injury and mediates tissue injury in the absence of complement C4.

4. Gene targeting of mouse TDP-43 (zeige TARDBP Proteine) negatively affects Masp2 expression.

5. ALI in H5N1-infected mice was caused by excessive complement activation, as demonstrated by deposition of C3, C5b-9, and MBL-C in lung tissue, and by up-regulation of MBL-associated serine protease-2 and the complement receptors C3aR (zeige C3AR1 Proteine) and C5aR (zeige C5AR1 Proteine).

6. study corroborates the essential function of MASP-2 in the lectin pathway and highlights the importance of mannan-binding lectin-independent lectin pathway activation in the host defense against pneumococci

7. Targeting of mannan-binding lectin (zeige MBL2 Proteine)-associated serine protease-2 (zeige PRSS2 Proteine) confers protection from myocardial and gastrointestinal ischemia/reperfusion injury.

8. Recombinant protein of masp2 was made and purified.

9. MASP-2 is essential for the activation of C4 and sMAP plays a regulatory role in the activation of the lectin pathway.

10. MASP-1 (zeige MASP1 Proteine) contributes to the activation of the lectin pathway, probably through the activation of MASP-2.