KCNQ2 Produkte
(Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2))
Kategorien
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Ausgewählte KCNQ2 Kategorien
KCNQ2 Antikörper
High quality antibodies with extensive validation data.
KCNQ2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene KCNQ2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Applikation
WB, IHC
Validierungen
- (2)
- (3)
Kat. Nr.
ABIN2776304
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Applikation
WB, IHC
Validierungen
- (4)
Kat. Nr.
ABIN2776303
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Bat, Chicken, Cow, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Rat
Applikation
WB, IHC, IHC (p)
Validierungen
- (2)
Kat. Nr.
ABIN202417
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene KCNQ2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1308478
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Insect Cells
Validierungen
- (1)
Kat. Nr.
ABIN3093344
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Insect Cells
Validierungen
- (1)
Kat. Nr.
ABIN3120435
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren KCNQ2 Produkten
: "Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of Kv7.2 and Kv7.3 potassium channel subunits." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 9, pp. 3782-93, (2015) (PubMed).: "Epilepsy-causing mutations in Kv7.2 C-terminus affect binding and functional modulation by calmodulin." in: Biochimica et biophysica acta, Vol. 1852, Issue 9, pp. 1856-66, (2015) (PubMed).
: "K(V)7.4 channels participate in the control of rodent renal vascular resting tone." in: Acta physiologica (Oxford, England), Vol. 214, Issue 3, pp. 402-14, (2015) (PubMed).
: "Novel KCNQ2 and KCNQ3 mutations in a large cohort of families with benign neonatal epilepsy: first evidence for an altered channel regulation by syntaxin-1A." in: Human mutation, Vol. 35, Issue 3, pp. 356-67, (2014) (PubMed).
: "Polarized axonal surface expression of neuronal KCNQ potassium channels is regulated by calmodulin interaction with KCNQ2 subunit." in: PLoS ONE, Vol. 9, Issue 7, pp. e103655, (2014) (PubMed).
: "Membrane microdomain determines the specificity of receptor-mediated modulation of Kv7/M potassium currents." in: Neuroscience, Vol. 254, pp. 70-9, (2013) (PubMed).
: "Kv7/M-type potassium channels in rat skin keratinocytes." in: Pflügers Archiv : European journal of physiology, Vol. 465, Issue 9, pp. 1371-81, (2013) (PubMed).
: "Functional effects of KCNQ K(+) channels in airway smooth muscle." in: Frontiers in physiology, Vol. 4, pp. 277, (2013) (PubMed).
: "Developmental expression of Kv potassium channels at the axon initial segment of cultured hippocampal neurons." in: PLoS ONE, Vol. 7, Issue 10, pp. e48557, (2012) (PubMed).
: "Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 48, pp. 17637-48, (2011) (PubMed).
Synonyme und alternative Namen zu KCNQ2
potassium voltage-gated channel subfamily Q member 2 (KCNQ2), potassium voltage-gated channel, subfamily Q, member 2 (Kcnq2), potassium voltage-gated channel subfamily Q member 2 (Kcnq2), potassium voltage-gated channel subfamily KQT member 2 (LOC100537363), potassium voltage-gated channel, KQT-like subfamily, member 2a (kcnq2a), BFNC, BFNS1, EBN, EBN1, EIEE7, ENB1, HNSPC, KCNA11, KQT2, KV7.2, KVEBN1, mKQT2.3, mKQT2.4, Nmf134, zgc:171872Bezeichner auf Proteinebene für KCNQ2
- KQT-like 2
- neuroblastoma-specific potassium channel protein
- neuroblastoma-specific potassium channel subunit alpha KvLQT2
- potassium voltage-gated channel subfamily KQT member 2
- voltage-gated potassium channel subunit Kv7.2
- potassium channel subunit alpha KvLQT2
- potassium voltage-gated channel, subfamily Q, member 2
- potassium voltage-gated channel KQT-like subfamily member 2.3
- potassium voltage-gated channel KQT-like subfamily member 2.4
- potassium voltage-gated channel, KQT-like subfamily, member 2
- LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily KQT member 2
- uncharacterized protein LOC100141342
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