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Human SOCS3 Protein expressed in Wheat germ - ABIN1320930
Jiang, Biswas, Steinle: Serine 307 on insulin receptor substrate 1 is required for SOCS3 and TNF-? signaling in the rMC-1 cell line. in Molecular vision 2014
we report the surprising finding that zebrafish respond to optic nerve lesion by inducing the expression of Sfpq and Socs3a
stat3 (zeige STAT3 Proteine)/socs3 pathway is a key response in all tissue regeneration in zebrafish.
Trpm7 (zeige TRPM7 Proteine) regulates exocrine pancreatic development via the Mg(2 (zeige MCOLN1 Proteine)+)-sensitive Socs3a pathway.
SOCS3 expression in response to trauma is unaffected by blockade of the mitogen-activated protein kinase (zeige MAPK1 Proteine) pathway by chemical inhibitors
The suppressor of cytokine signaling 3 gene was identified in this species, and the base sequence and deduced amino acid sequence are presented.
in homozygotes, GH signaling is reduced by the action of the SOCS1 (zeige SOCS1 Proteine) and SOCS3 proteins.
SOCS3 overexpression decreased JAK (zeige JAK3 Proteine)-STAT3 (zeige STAT3 Proteine) signaling pathway activity, declined Bcl-2 (zeige BCL2 Proteine) expression, inhibited cell proliferation, elevated cell apoptosis, and enhanced Adriamycin sensitivity in T24 cells
miR203 expression may be upregulated by IL17 (zeige IL17A Proteine) stimulation, and miR203 is a positive regulator of IL17induced VEGF (zeige VEGFA Proteine) secretion.
SOCS3 DNA methylation (zeige HELLS Proteine) is associated with body weight and moderates the effect of cumulative stress on obesity.
SOCS3 was targeted by miR30a- 5p in allergic rhinitis
Cellular viability was significantly decreased, whereas IL6 (zeige IL6 Proteine) and TNFalpha (zeige TNF Proteine) levels were significantly increased, following High Glucose stimulation of A549 cells. In addition, the protein levels of SOCS3, pJAK2 and pSTAT3 were significantly increased in High Glucosetreated cells.
this study shows that Nrf2 (zeige GABPA Proteine) activation induces lipocyte phenotype in hepatic stellate cells via enhancing SOCS3-dependent feedback inhibition on JAK2 (zeige JAK2 Proteine)/STAT3 (zeige STAT3 Proteine) cascade
SOCS-1 (zeige SOCS1 Proteine), SOCS-2 (zeige SOCS2 Proteine), and SOCS-3 proteins may directly or indirectly, have important roles in development and pathogenesis of papillary thyroid cancer
Our study showed that the expressions of HER2 (zeige ERBB2 Proteine), STAT3 (zeige STAT3 Proteine), and SOCS3 are associated with the progression of ovarian cancer (OC), and higher expressions of HER2 (zeige ERBB2 Proteine) and STAT3 (zeige STAT3 Proteine) and lower expression of SOCS3 predict poor prognosis of OC.
Authors found that SOCS3 and SOCS1 (zeige SOCS1 Proteine) expression was reduced in vivo, in tumor lesions of BCC and SCC (zeige CYP11A1 Proteine), as compared to other skin inflammatory conditions such as psoriasis, despite the high number of IL-22 (zeige IL22 Proteine)-secreting TILs.
the presence of SOCS3 methylation is a marker to predict treatment response and prognosis in HCC (zeige FAM126A Proteine) patients receiving TACE (zeige ADAM17 Proteine) therapy.
In porcine circovirus type 2 subclinical infection, SOCS3 interacted with STAT3 (zeige STAT3 Proteine) and TNF receptor-associated factor 2 (zeige TRAF2 Proteine), suggesting mechanisms by which SOCS3 inhibits IL-6 (zeige IL6 Proteine) and TNF-alpha (zeige TNF Proteine) signaling.
SOCS3 is an important negative regulator of insulin (zeige INS Proteine) signaling in porcine adipocytes.
Low SOCS3 expression is required for milk synthesis and proliferation of dairy cow mammary epithelial cells in vitro.
Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 (zeige IL10 Proteine) and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.
In the present study, we investigated the hypothesis that SOCS3 expression in the VMH could exert an important role regulating the metabolic changes typically observed during pregnancy and lactation.
SOCS3 was upregulated in lung CD4 (zeige CD4 Proteine)+ T cells in a mouse model of chronic PA lung infection and exogenous SOCS3 suppressed Th17-mediated neutrophil recruitment in vitro.
findings show SOCS3 does not appear to mediate the early inflammatory or leucine-induced changes in protein synthesis in skeletal muscle
The strength of long bones is determined by coalescence of trabeculae during corticalization.This process is regulated by SOCS3 via a mechanism dependent on IL-6 (zeige IL6 Proteine) and expression of sex hormones.
High SOCS3 expression is associated with glioma.
Mechanistic analysis indicated that E47 (zeige TCF3 Proteine) activated expression of the transcription factor Spi-B (zeige SPIB Proteine) and the suppressor of cytokine signaling 3 (SOCS3), which both downregulated Foxp3 (zeige FOXP3 Proteine) expression. These findings demonstrate that the balance of Id3 (zeige ID3 Proteine) and E47 (zeige TCF3 Proteine) controls the maintenance of Foxp3 (zeige FOXP3 Proteine) expression in Treg cells and, thus, contributes to Treg cell plasticity.
Our results show, for the first time, that SOCS-3 regulates leptin (zeige LEP Proteine)-induced responses in cartilage
Loss of suppressor of cytokine (SOCS3) expression in mature muscle fibers increased the inflammatory response to myotoxic injury but did not impair muscle regeneration in either adult or old mice. Therefore, reduced SOCS3 expression in muscle fibers is unlikely to underlie impaired muscle regeneration.
Findings revealed a novel participation of SOCS3 regulating several endocrine and metabolic aspects.
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
suppressor of cytokine signaling 3
, suppressor of cytokine signaling 3a
, STAT-induced STAT inhibitor 3
, cytokine-inducible SH2 protein 3
, cytokine signaling suppressor
, E2a-Pbx1 target gene in fibroblasts 10
, cytokine inducible SH2-containing protein 3
, suppressors of cytokine signaling 3