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Human SOCS3 Protein expressed in Wheat germ - ABIN1320930
Jiang, Biswas, Steinle: Serine 307 on insulin receptor substrate 1 is required for SOCS3 and TNF-? signaling in the rMC-1 cell line. in Molecular vision 2014
we report the surprising finding that zebrafish respond to optic nerve lesion by inducing the expression of Sfpq and Socs3a
stat3 (zeige STAT3 Proteine)/socs3 pathway is a key response in all tissue regeneration in zebrafish.
Trpm7 (zeige TRPM7 Proteine) regulates exocrine pancreatic development via the Mg(2 (zeige MCOLN1 Proteine)+)-sensitive Socs3a pathway.
SOCS3 expression in response to trauma is unaffected by blockade of the mitogen-activated protein kinase (zeige MAPK1 Proteine) pathway by chemical inhibitors
The suppressor of cytokine signaling 3 gene was identified in this species, and the base sequence and deduced amino acid sequence are presented.
in homozygotes, GH signaling is reduced by the action of the SOCS1 (zeige SOCS1 Proteine) and SOCS3 proteins.
the presence of SOCS3 methylation is a marker to predict treatment response and prognosis in HCC (zeige FAM126A Proteine) patients receiving TACE (zeige ADAM17 Proteine) therapy.
anti-miR (zeige MLXIP Proteine)-203 suppresses breast cancer cell proliferation in vitro by targeting SOCS3 [review]
miR (zeige MLXIP Proteine)-2909 could play a vital role in prostate carcinogenesis through modulation of ISGylation system and TGFbeta (zeige TGFB1 Proteine) signalling via STAT1 (zeige STAT1 Proteine)/SOCS3.
Data show that miR (zeige MLXIP Proteine)-222-3p targeted SOCS3 genes and down-regulation of SOCS3 correlated with an increased expression of STAT3 (zeige STAT3 Proteine) activation.
increased SOCS3 in combined IL-33 (zeige IL33 Proteine) heterozygotes and minor allele homozygotes may be relevant for hay (zeige GTF2H5 Proteine) fever development
In summary, this study has shown that LIF (zeige LIF Proteine) is implicated in the HG-mediated inhibition of osteoblast differentiation, via promoting STAT3 (zeige STAT3 Proteine)/SOCS3 signaling. This study may provide insights into the signal pathway of HG-induced bone loss or delayed injured joint healing.
Data suggest that SOCS3 is an important signaling protein in CLL, and Hsp90 (zeige HSP90 Proteine) inhibitors represent an approach to target transcriptional repression in B cell lymphoproliferative disorders.
6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiated the inhibitory effect of IFN-alpha (zeige IFNA Proteine) on hepatocellular carcinoma cell proliferation through activation of the JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) signaling pathway by inhibiting SOCS3 expression.
SOCS3 was down-regulated in CML cell lines and most of BMNCs from CML patients, and the expression level of SOCS3 was associated with the inhibition of cell proliferation and drug resistance of CML cells.
SOCS3 is involved in suppression of Helicobacter pylori induced STAT3 (zeige STAT3 Proteine) phosphorylation by docosahexaenoic acid pretreatment.
SOCS3 is an important negative regulator of insulin (zeige INS Proteine) signaling in porcine adipocytes.
Low SOCS3 expression is required for milk synthesis and proliferation of dairy cow mammary epithelial cells in vitro.
Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 (zeige IL10 Proteine) and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.
findings show SOCS3 does not appear to mediate the early inflammatory or leucine-induced changes in protein synthesis in skeletal muscle
The strength of long bones is determined by coalescence of trabeculae during corticalization.This process is regulated by SOCS3 via a mechanism dependent on IL-6 (zeige IL6 Proteine) and expression of sex hormones.
High SOCS3 expression is associated with glioma.
Mechanistic analysis indicated that E47 (zeige TCF3 Proteine) activated expression of the transcription factor Spi-B (zeige SPIB Proteine) and the suppressor of cytokine signaling 3 (SOCS3), which both downregulated Foxp3 (zeige FOXP3 Proteine) expression. These findings demonstrate that the balance of Id3 (zeige ID3 Proteine) and E47 (zeige TCF3 Proteine) controls the maintenance of Foxp3 (zeige FOXP3 Proteine) expression in Treg cells and, thus, contributes to Treg cell plasticity.
Our results show, for the first time, that SOCS-3 regulates leptin (zeige LEP Proteine)-induced responses in cartilage
Loss of suppressor of cytokine (SOCS3) expression in mature muscle fibers increased the inflammatory response to myotoxic injury but did not impair muscle regeneration in either adult or old mice. Therefore, reduced SOCS3 expression in muscle fibers is unlikely to underlie impaired muscle regeneration.
Findings revealed a novel participation of SOCS3 regulating several endocrine and metabolic aspects.
Findings indicate that inactivation of the Rb family proteins (Rb, p107 (zeige RBL1 Proteine), and p130) in hematopoietic stem cells (HSCs) progressively impairs their homeostasis, which is rescued upon repression of suppressor of cytokine signaling 3 protein (Socs3) expression in triple knockout (TKO (zeige MRPS12 Proteine)) HSCs.
Data suggest that, in B cell lymphoma, expression of MIRN30 is up-regulated in both granulocytic myeloid-derived suppressor cells and monocytic myeloid-derived suppressor cells; in B cell lymphoma, 3prime untranslated region of Socs3 appears to be direct target of MIRN30 in myeloid-derived suppressor cell differentiation. (MIRN30 = microRNA 30; Socs3 = suppressor of cytokine signaling 3 protein)
Cell type-specific, different roles for viral immediate early (zeige JUN Proteine) or early gene expression and/or viral tegument proteins in the early stimulation of SOCS1 (zeige SOCS1 Proteine) and SOCS3 during murine cytomegalovirus infection.
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
suppressor of cytokine signaling 3
, suppressor of cytokine signaling 3a
, STAT-induced STAT inhibitor 3
, cytokine-inducible SH2 protein 3
, cytokine signaling suppressor
, E2a-Pbx1 target gene in fibroblasts 10
, cytokine inducible SH2-containing protein 3
, suppressors of cytokine signaling 3