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Down-regulation of gamma(c) during early HIV/SIV infection may inhibit T-cell function, particularly of CD8 (zeige CD8A Proteine)(+) T cells, and, may be linked with immune failure and loss of viral containment.
New insights of common gamma chain in hematological malignancies.
this study shows that downregulation of miR (zeige MLXIP Proteine)-3940-5p promotes T-cell activity by targeting the cytokine receptor (zeige EBI3 Proteine) IL-2R gamma on human cutaneous T-cell lines
Characterization of interleukin receptor beta/gamma-associated protein complex assembly in IL-2 (zeige IL2 Proteine)- and IL-15 (zeige IL15 Proteine)-activated T-cells has been reported.
systematic scoping review highlights the many potential uses of soluble interleukin-2 (zeige IL2 Proteine) receptor measurement in the diagnosis and treatment of hemophagocytic syndromes.
analysis of the contribution of IL2Rgamma to the dynamic formation of IL2 (zeige IL2 Proteine)-IL2R (zeige IL2RA Proteine) complexes
A deletion mutation in IL2RG gene results in X-linked severe combined immunodeficiency (zeige PRKDC Proteine) with an atypical phenotype
novel missense mutation in Japanese patient results in atypical X-linked severe combined immunodeficiency (zeige PRKDC Proteine) with the presence of T cells and NK cells and revertant somatic mosaicism
reversion of mutation in common lymphoid progenitor results in mild phenotype of SCID (zeige PRKDC Proteine)
High IL2RG expression is associated with Sezary syndrome.
Identification of a gammaC splice isoform revealed expression of soluble gammaC proteins (sgammaC). sgammaC directly interacted with surface IL-2Rbeta (zeige IL2RB Proteine) to suppress IL-2 (zeige IL2 Proteine) signaling and to promote pro-inflammatory Th17 cell differentiation. [review]
Suggest that soluble common gamma chain may be one of the target molecules for the control of immunopathogenic progresses in COPD (zeige ARCN1 Proteine).
Results indicate that conjugated-interleukin-2 (IL2 (zeige IL2 Proteine)) protein derived from NKTR (zeige NKTR Proteine)-214 occupy interleukin-2 (IL2 (zeige IL2 Proteine)) receptor complex (IL2Ralphabetagamma) to a greater extent compared to free-IL2 (zeige IL2 Proteine) protein.
Renal lesions are indeed modulated by intrinsic glomerular cells through the gamma-C/IL-2 (zeige IL2 Proteine)-beta receptor response, to date classically described only in immune cells.
degree to which immune rejection contributes to these disappointing outcomes using an immunodeficient IL2 receptor gamma (IL2rgamma)-null mouse model, was examined.
We have confirmed the activation of human peripheral blood lymphocytes after being xenografted in immunodeficient Rag2 (zeige RAG2 Proteine)-/-IL2Rgnull mice.
Results demonstrate that IL2Rgamma has an onogenic role in JAK3 (zeige JAK3 Proteine)-mutation-positive leukemias.
findings demonstrate that NOD SCID (zeige PRKDC Proteine) IL2R (zeige IL2RA Proteine) common gamma chain -/- mice are capable of engraftment of canine PBLs yet develop graft versus host disease similar to Hu-PBL-SCID (zeige PRKDC Proteine) mice
Interleukin-2 (zeige IL2 Proteine) signalling is modulated by a labile disulfide bond in the CD132 chain of its receptor.
gammac expression was required to signal the differentiation of MHC class I-specific thymocytes into CD8 (zeige CD8A Proteine)+ cytotoxic lineage T cells and into invariant natural killer T cells.
analysis of multiorgan metastasis of human HER-2 (zeige ERBB2 Proteine)+ breast cancer in Rag2 (zeige RAG2 Proteine)-/-;Il2rg-/- mice and treatment with PI3K inhibitor
The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.
cytokine receptor common subunit gamma
, interleukin 2 receptor gamma
, interleukin 2 receptor, gamma (severe combined immunodeficiency)
, membrane receptor Il2rg
, interleukin 2 receptor, gamma
, CD132 antigen
, IL-2 receptor subunit gamma
, IL-2R subunit gamma
, common cytokine receptor gamma chain
, IL-2R gamma chain
, cytokine receptor common gamma chain
, interleukin-2 receptor gamma chain
, interleukin-2 receptor subunit gamma
, interleukin 2 receptor gamma chain
, common gamma chain
, gamma C receptor