anti-IL21 Receptor (IL21R) Antikörper

Horse (Equine) Interleukin 21 Receptor (IL21R) Interaktionspartner

1. IL21R is probably not causally involved in recurrent airway obstruction.

Human Interleukin 21 Receptor (IL21R) Interaktionspartner

1. The number of IL-2-dependent FoxP3(+) regulatory T cells is increased in the peripheral blood of human patients with loss-of-function mutations in the IL-21 receptor (IL-21R).

2. bone marrow monocytes from multiple myeloma patients show distinct features compared to those from patients with indolent monoclonal gammopathies, supporting the role of IL21R over-expression by bone marrow CD14(+) cells in enhanced osteoclast formation.

3. Report increased levels of IL-21R in the skeletal muscle endothelial cells of patients with peripheral arterial disease compared to control individuals.

4. expression of IL-21 and IL-21R were up-regulated in autoimmune thyroid disease and may be involved in the pathogenesis of the disease through augmenting aberrant immune cascade

5. interleukin-21 receptor deficiency is associated with Severe Combined Immunodeficiency.

6. IL-21R on B cells is upregulated in allergic rhinitis patients when compared to controls. IL-21/IL-21R may be involved in the regulation of allergic reactions through the inhibition of IgE.

7. IL-21/IL-21R could act as potential biomarkers presenting early systemic sclerosis skin lesions severity.

8. STAT3 signaling downstream of IL-23R and IL-21R has a role in controlling human mucosal-associated invariant T cells and NKT cell numbers

9. Human neutrophils in peripheral blood express functional IL-21 receptors.

10. IL-21R gene polymorphisms and serum IL-21 levels predict virological response to interferon-based therapy in Asian chronic hepatitis C patients.

11. Abundant expression of interleukin-21 receptor in follicular lymphoma cells is associated with more aggressive disease.

12. Data suggest that IL21 rs2221903 and IL21R rs3093301 polymorphisms may, independently or interactively, affect the susceptibility to and/or persistence of HBV infection potentially through altering IL-21 and IgE production.

13. The IL-21R/STAT3 pathway is required for many aspects of human CD8(+) T-cell behavior but in some cases can be compensated by other signals.

14. Human monocyte-like THP-1 cells express two IL-21 receptor components, CD132 (gammac) and IL-21Ralpha, on their cell surface, as assessed by flow cytometry.

15. human IL-21R deficiency causes an immunodeficiency and highlights the need for early diagnosis

16. For risk-factor studies, anti-citrullinated peptide antibody-positive (CCP)-negative rheumatoid arthritis patients can be studied as one group via measurement of their IL-21 and IL-21 receptor levels.

17. Crystal structure of IL-21 binding to IL-21R reveals that the WSXWS motif of IL-21R is C-mannosylated at the first tryptophan.

18. IL21R and vezatin were also cleaved in apoptotic HeLa cells with the cleavage sites Asp344, Asp655 and Asp53.

19. Data suggest that the association of 2009 H1N1 vaccine-induced Ab responses with IL-21/IL-21R upregulation and with development of memory B cells and plasmablasts has implications for future research in vaccine design.

20. These findings suggest role(s) for IL-21 in both the acute and chronic stages of multiple sclerosis via direct effects on T and B lymphocytes and, demonstrated for the first time, also on neurons.

Mouse (Murine) Interleukin 21 Receptor (IL21R) Interaktionspartner

1. In mice, IL-21:IL-21R interactions influence the phenotype of T follicular cells, reducing the expression of CXCR4 and inhibiting the expansion of Tfr cells after T-cell-dependent immunization. The negative effect of IL-21 on Tfr cells in mice is cell intrinsic and associated with decreased expression of the high affinity IL-2 receptor (CD25).

2. IL21R signal my contribute to anti-adenine nucleotide translocator antibody production and expansion of B cells in viral myocarditis

3. this study shows that IL-21R signaling is essential for the optimal control of Mycobacterium tuberculosis infection

4. natural genetic variation in murine Il21r influences neuronal cell viability after ischemia by modulating receptor function and downstream signal transduction

5. IL-21 may play an important role in the pathogenesis of SSc as a Th17 effector cytokine, and IL-21 may induce the differentiation of Th17 cells in the BLM-induced systemic sclerosis mouse model via Il21R.

6. Gene expression analyses of angioimmunoblastic T-cell lymphoma (AITL), showed that essentially all cases expressed elevated levels of transcripts for IL21, IL21R, and a series of genes associated with TFH cell development and function.

7. IIl21r deletion reduced spontaneous EAE associated with defective Th17 cell generation. IL-21R deficiency limited IL-23R expression on Th17 cells and inhibited expression of key molecules for pathogenic Th17 cell generation.

8. our data demonstrate the novel finding that the IL-21R plays a critical role in regulating innate immune responses against HSV-2 infection.

9. During experimental arthritis, IL-21R deficiency protected against severe inflammation and joint destruction. This was accompanied by suppressed serum IgG1 levels and antigen-specific T cell responses.

10. in the absence of IL-21/IL-21R signaling, Il2(-/-) mice retained a deficiency in Tregs yet exhibited a reduced and delayed inflammatory disease which was reflected in reduced pancreatitis and hemolytic anemia

11. IL-21R expression on donor CD4+ T cells is essential for sustaining T cell number and help for B cells, resulting in more severe lupus-like renal disease, but it does not alter the balance of T helper (Th)17 cells and regulatory T cells.

12. IL-21R controls both antigen transport by DCs and the crucial beacon function of CD4(+) cells for autoreactive CD8(+) cells to reach the islets.

13. Data indicate that CD8KO recipients given either C57Bl/6 or IL-21RKO CD8+ cells showed the recipients given C57Bl/6 CD8+ cells with significantly greater myocarditis than recipients of IL-21RKO CD8+ cells.

14. IL-21 and IL-2 can have overlapping roles in promoting conventional T-cell responses but play distinct roles in controlling Treg homeostasis and function.

15. study demonstrated T-extrafollicular helper cells are dependent on IL-21R for their generation; study highlighted that IL-21R signaling is necessary for the spontaneous accumulation of multiple B and T cell effector populations in MRLlpr mice

16. IL-21R KO and wild-type donor T cells showed equivalent alloactivation, but IL-21R KO T cells showed decreased infiltration and inflammatory cytokine production within the mesenteric lymph nodes.

17. Following secondary immunization of IL-21 receptor knockout mice, IgG antibody responses to hapten-onjugated chicken gamma globulin are significantly impaired, identifying the IL-21 pathway as a critical component of the memory B cell response.

18. Recipients of donor CD4-positive T cells lacking IL-21 receptor exhibit diminished graft-versus-host disease symptoms, with reduced inflammatory cell infiltration into the liver and intestine, leading to prolonged survival

19. Germinal center reactions and B cell responses induced by immunization with virus-like particles are strongly reduced in both global and B cell-specific IL-21 receptor-deficient mice.

20. Increased IL-21 and IL-21R expression may be involved in the development of experimental autoimmune uveitis, possibly by promoting IL-17 secretion.