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Results show that removal of type-1 IFN signalling in the APPSWE/PS1DeltaE9 mouse model of AD confers a predominantly anti-inflammatory glial response and protects from cognitive decline. However this phenotype does not correlate with alterations in amyloid deposition and only a modest reduction in Abeta (zeige APP Proteine) monomer levels.
transfusion-induced differentiation of IFNAR1(-/-) B cells into germinal center B cells and plasma cells was significantly reduced, compared to WT B cells. This study demonstrates that B cells require signaling from IFN-alpha (zeige IFNA Proteine)/beta to produce alloantibodies to the human KEL glycoprotein in mice.
These data suggest that plasmacytoid dendritic cells producing IFN-alpha (zeige IFNA Proteine) and IL-33 (zeige IL33 Proteine) play a pivotal role in the chronic fibro-inflammatory responses underlying murine autoimmune pancreatitis and human IgG4-related autoimmune pancreatitis.
type I interferons, besides their known antiviral properties, can initiate the recruitment and activation of leukocytes via induction of chemokine (zeige CCL1 Proteine) expression including CCL2 (zeige CCL2 Proteine).
this study shows that the presence of IFN-alpha (zeige IFNA Proteine) at antigen sensitization activates an IDO1 (zeige IDO1 Proteine)/TGF-beta (zeige TGFB1 Proteine)-dependent anti-inflammatory program that upon antigenic rechallenge prevents inflammation via plasmacytoid dendritic cells
these studies demonstrate an important role for type I IFN in skin fibrosis, and they provide a rationale for IFNAR1 inhibition in scleroderma
These results identify a key interface created by IFNAR1 residues Tyr (zeige TYR Proteine)(240) and Tyr (zeige TYR Proteine)(274) interacting with IFN-beta (zeige IFNB1 Proteine) residues Phe(63), Leu(64), Glu (zeige GCG Proteine)(77), Thr (zeige TRH Proteine)(78), Val(81), and Arg(82) that underlie IFN-beta (zeige IFNB1 Proteine)-IFNAR1-mediated signaling and biological processes.
IFNAR1-deficiency accelerated humoral immune responses and parasite control by boosting ICOS (zeige ICOS Proteine)-signalling in two non-lethal murine models of malaria
reduced type I interferon (zeige IFNA Proteine) production in obesity is caused by SOCS3 (zeige SOCS3 Proteine) overexpression as well as tolerance induced by leptin (zeige LEP Proteine)
Downregulation of IFNAR1 promotes melanoma development and progression. IFNAR1 mutation, which is partially resistant to downregulation, delays melanoma development.
Low IFNAR1 expression is associated with peritoneal metastasis in gastric cancer.
the level of IFNAR1, IFNAR2, and CCR5 mRNA expression was found to be significantly lower in the responders than nonresponders.Our results highlighted the significance of IFNAR and CCR5 genes in multiple sclerosis risk and the response to IFN-b therapy.
Downregulation of IFNAR1 in tumor stroma stimulated colorectal cancer development and growth, played a key role in formation of the immune-privileged niche.
These results suggest that miR-29a, upregulated during RSV infection, is a negative regulator of IFNAR1 and is critical for respiratory syncytial virus NS1-induced virus replication.
On one hand, hepatitis B virus activates MMP-9 (zeige MMP9 Proteine) in infected patients and leukocytes. On the other hand, MMP-9 (zeige MMP9 Proteine) facilitates hepatitis B virus replication through repressing IFN/JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) signaling, IFNAR1 function, and IFN-alpha (zeige IFNA Proteine) action.
this study shows that single nucleotide polymorphism in IFNAR1 gene is associated with female vitiligo (zeige MITF Proteine) in Estonian patients
A small proportion of both pancreatic and periampullary tumors showed a strong expression of the IFNAR-1.
rs2843710 of IFNAR1 was associated with the susceptibility and severity of EV71 HFMD in Chinese Han populations.
Genetic polymorphisms of the promoter of INFAR gene represent important factors associated with the clinical phase of HBeAg-negative chronic HBV infection.
data illustrate a lipid G-protein coupled receptor (GPCR (zeige TAS1R3 Proteine))-IFNAR1 regulatory loop that balances effective and detrimental immune responses and elevated endogenous S1PR1 (zeige S1PR1 Proteine) signaling
Mutation of the IFNAR-1 receptor binding site of human IFN-alpha2 (zeige IFNA2 Proteine) generates type I IFN competitive antagonists.
The complete 168,835 bp insert sequence of a porcine BAC clone harboring the IFNAR1 gene was determined.
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.
interferon alpha/beta receptor 1
, interferon receptor
, soluble receptor
, interferon-alpha receptor 1
, putative interferon-alpha/beta receptor alpha chain
, interferon receptor 1
, interferon (alpha, beta and omega) receptor 1
, interferon alpha/beta receptor 1-like
, IFN-alpha/beta receptor 1
, INF-a receptor
, interferon-alpha/beta receptor 1
, type I interferon receptor 1
, alpha-type antiviral protein
, beta-type antiviral protein
, cytokine receptor class-II member 1
, cytokine receptor family 2 member 1
, interferon-alpha/beta receptor alpha chain
, interferon-beta receptor 1
, interferon (alpha and beta) receptor 1
, interferon, alpha; receptor
, Interferon-alpha/beta receptor alpha chain