IFNAR1 Protein (His tag)

Produktnummer ABIN7320999

Produktdetails

Target: IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

Protein-Typ: Recombinant

Spezies: Rhesusaffen

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses IFNAR1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Rhesus macaque IFNAR1 Protein (His Tag)

Sequenz: Ala25-Lys437

Produktmerkmale: Recombinant Rhesus macaque IFNAR1 is produced by our Mammalian expression system and the target gene encoding Ala25-Lys437 is expressed with a 6His tag at the C-terminus.

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Kommentare:

70-120 kDa

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

Andere Bezeichnung: IFNAR1 (IFNAR1 Produkte)

Synonyme: ifnar1 Protein, IFNAR1 Protein, CD118 Protein, Ifar Protein, Ifnar Protein, Ifrc Protein, Infar Protein, AVP Protein, IFN-alpha-REC Protein, IFNAR Protein, IFNBR Protein, IFRC Protein, IFN-R-1 Protein, interferon alpha and beta receptor subunit 1 Protein, interferon-alpha/beta receptor alpha chain-like Protein, interferon (alpha and beta) receptor 1 Protein, interferon alpha/beta receptor 1 Protein, IFNAR1 Protein, ifnar1 Protein, Ifnar1 Protein, LOC609830 Protein

Hintergrund:

Background: Interferon?alpha/beta receptor 1 (IFN? alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphorylation at Tyr-466. It also interacts with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.

Synonym: Alpha-type antiviral protein, AVP, beta-type antiviral protein, CRF2-1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC, IFN-alpha/beta R1, IFN-alpha/beta receptor 1, IFN-alpha-REC, IFNAR, IFNAR1, IFN-aR1, IFNBR, IFNbR1, IFN-bR1, IFN-R-1

Molekulargewicht: 48.4 kDa

UniProt: H9FTY3

Pathways: JAK-STAT Signalweg, Hepatitis C